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Genes coregulated by CDK8 (显示 CDK8 蛋白)/19 and NFkappaB (显示 NFKB1 蛋白) include IL8 (显示 IL8 蛋白), CXCL1 (显示 CXCL1 蛋白), and CXCL2 (显示 CXCL2 蛋白).
Moreover, it identified CDK19 and CDK8 (显示 CDK8 蛋白) to be specifically overexpressed during prostate cancer progression, highlighting their potential as novel therapeutic targets in advanced prostate cancer.
High CDK19 expression is associated with osteosarcoma.
On stimulation of TLR9 (显示 TLR9 蛋白), CDK8 (显示 CDK8 蛋白)/19 positively regulates inflammatory gene transcription in cooperation with NF-kappaB (显示 NFKB1 蛋白) and C/EBPbeta (显示 CEBPB 蛋白).
Data suggest that, during neurogenesis, Mediator complex cyclin-dependent kinases (CDK8, CDK19) interact directly with PRC2 (polycomb repressive complex 2) subunit EZH2 (enhancer of zeste homolog 2), as well as SUZ12 (suppressor of zeste 12 homolog).
Mediator-associated kinases CDK8 (显示 CDK8 蛋白) and CDK19 restrain increased activation of key super-enhancer-associated genes in acute myeloid leukaemia (AML (显示 RUNX1 蛋白)) cells
Microarrays identified target genes for each CDK (显示 CDK4 蛋白), and we selected six genes: two target genes of CDK8 (显示 CDK8 蛋白), two target genes of CDK19 and two genes that were targets for both.
CDK8 (显示 CDK8 蛋白) and CDK19, individually interact with PRMT5 (显示 PRMT5 蛋白) and WDR77 (显示 WDR77 蛋白), and their interactions with PRMT5 (显示 PRMT5 蛋白) cause transcriptional repression of C/EBPbeta (显示 CEBPB 蛋白) target genes.
This gene encodes a protein that is one of the components of the Mediator coactivator complex. The Mediator complex is a multiprotein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex.
CDC2-related protein kinase 6
, CDK8-like cyclin-dependent kinase
, cell division cycle 2-like 6 (CDK8-like)
, cell division cycle 2-like protein kinase 6
, cell division protein kinase 19
, cyclin dependent kinase 19 variant 2
, cyclin-dependent kinase (CDC2-like) 11
, cyclin-dependent kinase 11
, death-preventing kinase
, cyclin-dependent kinase 8