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DNA methylation (显示 HELLS 蛋白) exists in the CDC2L1 gene promoter region in keloid tissue fibroblasts. DNA methylation (显示 HELLS 蛋白) of the CDC2L1 gene promoter region dramatically inhibits the expression of CDK11p58 protein in keloid tissues.
CDK11 has a role in human cancers [review]
we showed high expression of CDK11 in metastatic and recurrent ovarian cancer and demonstrated that CDK11 is essential for ovarian cancer cell growth and survival in vitro and in vivo.
CDK11 was found associated with the TREX/THOC, which recruited this kinase to DNA. Once at the viral genome, CDK11 phosphorylated serines at position 2 in the CTD of RNAPII, which increased levels of cleavage and polyadenylation factors at the HIV 3' end. In its absence, cleavage of viral transcripts was greatly attenuated.
Real-time PCR and dual-luciferase assay showed CDK11(p58) inhibited the mRNA levels of VEGF (显示 VEGFA 蛋白) and the promoter activity of VEGF (显示 VEGFA 蛋白)
Hepsin (显示 HPN 蛋白) suppressed CDK11p58 internal ribosome entry site activity in prostate cancer cells by modulating UNR (显示 P2RY4 蛋白) expression and eIF-2alpha (显示 EIF2S1 蛋白) phosphorylation.
CDK11 and CK2 (显示 CSNK2A1 蛋白) expression are individually essential for breast cancer cell survival, including TNBC.
CDK11(p58) kinase activity appears to be involved in early events in the establishment of the centromere protection machinery.
Data indicate that CDK11p58 is an anti-metastatic gene in ERalpha (显示 ESR1 蛋白)-positive breast cancer and that the regulation of integrin beta3 by CDK11p58 via the repression of ERalpha (显示 ESR1 蛋白) signaling may constitute part of a signaling pathway underlying breast cancer invasion.
CHK2 (显示 CHEK2 蛋白) kinase constitutively phosphorylates CDK11(p110) in a DNA damage-independent manner.
suggested that CDK11p58 acted to regulate microglia activation through CDK11p58 and cyclin D3 (显示 CCND3 蛋白) interaction
These data suggest that cyclin D3 (显示 CCND3 蛋白)/CDK11p58 signaling is involved in the negative regulation of AR function.
CDK11(p58) is expressed in proliferating germ cells in the early stages of developing testes
Cdc2l1 is a previously unrecognized member of the Hh signal transduction cascade.
This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L2, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L2, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L2 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Several alternatively spliced variants of this gene have been reported.
CDC-related protein kinase p58
, PITSLRE serine/threonine-protein kinase CDC2L1
, cell division cycle 2-like 1 (PITSLRE proteins)
, cell division cycle 2-like protein kinase 1
, cell division protein kinase 11B
, galactosyltransferase-associated protein kinase p58/GTA
, p58 CLK-1
, cyclin-dependent kinase 11B
, PITSLRE proteins
, cell division cycle 2 homolog-like 1
, cell division cycle 2 homolog-like 2
, cell division cycle 2-like 1
, cell division cycle 2-like 2
, cell division protein kinase 11
, cyclin-dependent kinase 11
, PITSLRE protein kinase beta 1
, cell division cycle 2-like 2 (PITSLRE proteins)
, cyclin-dependent kinase 11B S homeolog