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Human Polyclonal ABCB4 Primary Antibody for IHC (p), WB - ABIN390060
Ruetz, Gros: Phosphatidylcholine translocase: a physiological role for the mdr2 gene. in Cell 1994
Show all 2 Pubmed References
The functional impact of ABCB4 mutations found in progressive familial intrahepatic cholestasis type 3.
Several members of a family exhibited cholestasis and were found to have a substitution of glycine 68 by arginine in ABCB4 due to a missense mutation at base 202. The 18-year-old propositus was heterozygous for this mutation and also suffered acute pancreatitis.
ABCB4 variants identified in patients with biliary diseases
results are suggestive of a potential downstream molecular effect for the described polymorphisms on the expression pattern of the ABCB4 underlining the importance of synonymous variants
the first characterisation at the protein level of six ABCB4 variants (D243A, K435T, G535D, I490T, R545C, and S978P) previously found in patients with inflammatory liver diseases or liver cancer, is reported.
Ivacaftor is a potential therapy for selected patients with cystic fibrosis (显示 S100A8 抗体) with mutations of ABCB4.
Data show that patients with low multidrug resistance protein 3 (MDR3) expression were significantly associated with a better outcome than patients with high MDR3 expression.
In patients with intrahepatic cholestasis of pregnancy, ABCB4 gene mutation was not associated with response to ursodeoxycholic acid treatment.
Data suggest that MDR3 isoforms, both human and mouse isoforms, exhibit different affinities for fluorescent dyes and drugs; thus, ligands likely occupy partially overlapping but distinct binding sites.
Single-nucleotide polymorphism in ABCB4 gene is associated with gallbladder cancer.
These results provide evidence that zebrafish Pxr (显示 NR1I2 抗体) may play a role in MDR/MXR through transcriptional regulation of abcb4 and cyp3a65 gene expression.
Zebrafish Abcb4 plays crucial roles in cellular efflux of microcystin-LR and is a potential molecular marker for the monitoring of cyanobacteria contamination in the aquatic environment.
Findings imply a close link between Mdr2 (-/-) -associated tumorigenesis and perturbation of these biological processes and suggest potential extrahepatic functions of Mdr2.
The antifibrotic effects of rapamycin, everolimus, captopril and irbesartan seen in other models of fibrosis were not replicated in the Mdr2(-/-) model of liver fibrosis.
A new Mdr2(-/-) mouse model of sclerosing cholangitis with rapid fibrosis progression, early-onset portal hypertension, and liver cancer.
Glyceryl trinitrate improves hepatocyte engraftment and correction of metabolic disease in mdr2 (-/-) mice.
nsulin-like growth factor 1 enhances bile-duct proliferation and fibrosis in Abcb4(-/-) mice.
Data indicate that Abcb4-knockout mice displayed significantly (P<0.001) lower plasma glucose concentrations than corresponding wild-type controls.
Mdr2(-/-)IKK2(Hep-KO) mice remarkably recapitulate chronic liver failure in humans and might be of special importance for the study of the mechanisms contributing to the pathogenesis of end-stage chronic liver disease.
Flippase ATP8B1 (显示 ATP8B1 抗体) and the floppase ABCB4 have complementary functions in maintaining canalicular membrane integrity.
Downregulation of JunD (显示 JUND 抗体) and cyclin D1 (显示 CCND1 抗体) expression in myofibroblasts may be important regarding the mechanism of action of MTA (显示 DNMT1 抗体) in Mdr2-/- mice
The induction of Mdr2 mRNA and Mdr2 protein levels by fibrates is mediated by PPARalpha (显示 PPARA 抗体), while the induction of Mdr1a / 1b in vivo probably reflects a secondary phenomenon related to chronic PPARalpha (显示 PPARA 抗体) activation.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined\; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function.
ATP-binding cassette sub-family B member 4
, P glycoprotein 3/multiple drug resistance 3
, P-glycoprotein 3
, P-glycoprotein-3/multiple drug resistance-3
, multidrug resistance protein 3
, multiple drug resistance 3
, ABC efflux transporter 4
, multidrug resistance 3
, ATP-binding cassette, subfamily B, member 4
, P glycoprotein 2
, multidrug resistance protein 2
, ATP-binding cassette sub-family B (MDR/TAP) member 4 (P-glycoprotein 3/ multidrug resistance 2
, ATP-binding cassette sub-family B (MDR/TAP) member 4 (P-glycoprotein 3/ multidrug resistance 2)
, ATP-binding cassette, sub-family B (MDR/TAP), member 4 (P-glycoprotein 3/ multidrug resistance 2)
, P-glycoprotein 2
, P-glycoprotein 3/ multidrug resistance 2
, ATP-binding cassette, sub-family B (MDR/TAP), member 4
, multidrug resistance protein 3-like
, ATP-binding cassette transporter protein
, Beta-defensin 1
, Defensin, beta 1
, p-glycoprotein isoform III
, LOW QUALITY PROTEIN: phosphatidylcholine translocator ABCB4
, RUN domain containing 3B
, RUN domain-containing protein 3B
, phosphatidylcholine translocator ABCB4
, P glycoprotein 3/ multiple drug resistance 3