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Human Polyclonal TXK Primary Antibody for IHC (p), ELISA - ABIN544400
Haire, Ohta, Lewis, Fu, Kroisel, Litman: TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12. in Human molecular genetics 1994
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Human Polyclonal TXK Primary Antibody for ELISA, WB - ABIN450079
Suzuki, Nara, Suzuki: Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet's disease. in Clinical medicine & research 2006
These data indicate that PRN694 is a highly selective and potent covalent inhibitor of ITK and RLK, and its extended target residence time enables durable attenuation of effector cells in vitro and in vivo.
fuctions as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription
Th1 cells expressing Txk and Th1-associated cytokines may play a critical role in the development of skin and intestinal lesions in patients with Behcet's disease.
Itk and Txk exert their effects on T helper (Th) cell differentiation and function at the level of expression; transgenic Txk is not a specific regulator of Th1 responses.
Taken together, these data indicate that ITK plus RLK inhibition may have therapeutic potential in Th1-mediated inflammatory diseases.
TXK plays an overlapping role with ITK in iNKT cell development and function. ITK also has a unique function in the survival of iNKT cells, likely via a p53-dependent pathway.
The protein data combined with the association constants for binding of each proline-rich peptide to the corresponding SH3 domain provide an explanation for the opposing modes of self-association within the otherwise closely related Rlk and Itk proteins
Tec kinases play key roles in regulating TCR-mediated polarization of integrins and signaling molecules to the site of TCR stimulation as well as the up-regulation of integrin adhesion.
A role for Rlk kinase is demonstrated in CD8+ T cell signaling and function both in vitro and in vivo.
indicate a critical role for Itk and Rlk in conventional CD8(+) T cell development in the thymus
Tec kinases differentially regulate development of conventional versus nonconventional lymphocytes
Tec kinases Rlk and Itk together provide important signals for terminal maturation, efficient cytokine production, and peripheral survival of natural killer T (NKT) cells.
Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T- cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskekleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1 (Th1) cell- specific transcription factor and binds the promoter of IFNG to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr- 201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.
PTK4 protein tyrosine kinase 4
, protein-tyrosine kinase 4
, resting lymphocyte kinase
, tyrosine kinase
, tyrosine-protein kinase TXK
, TXK tyrosine kinase
, tyrosine-protein kinase TXK-like
, LOW QUALITY PROTEIN: tyrosine-protein kinase TXK