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We identified a double heterozygosity for pathogenic mutations in SCN5A (显示 SCN5A 蛋白) and TRPM4 in a Brugada syndrome patient.
The electron cryomicroscopy structure of human transient receptor potential melastatin (显示 TRPM1 蛋白) subfamily member 4 (TRPM4) in a closed, Na(+)-bound, apo (显示 C9orf3 蛋白) state at pH 7.5 to an overall resolution of 3.7 A is reported.
electron cryo-microscopy structure of the most widespread CAN channel, human TRPM4, bound to the agonist Ca(2 (显示 CA2 蛋白)+) and the modulator decavanadate
TRPM4 protein expression is up-regulated in diffuse large B cell lymphoma
study presents 2 structures of TRPM4 embedded in lipid nanodiscs at ~3-angstrom resolution, as determined by single-particle cryo-electron microscopy; these structures, with and without calcium bound, reveal a general architecture for this major subfamily of TRP (显示 TBPL1 蛋白) channels and a well-defined calcium-binding site within the intracellular side of the S1-S4 domain
Study supports the view that TRPM4 variants could be responsible for about 2% of LQT (显示 KCNQ1 蛋白) syndrome cases. The impact of these variants results in electrophysical disturbances.
A large pedigree diagnosed with progressive familial heart block type I was linked to a mutation of the TRPM4 ion channel.
Identify TRPM4 as a regulator of store operated calcium entry in prostate tumor cells, and demonstrate a role for TRPM4 in cancer cell migration.
TRPM4 channels regulate human detrusor smooth muscle excitability and contractility and are critical determinants of human urinary bladder function
TRPM4 protein expression is widely expressed in benign and cancerous prostate tissue
The activation of TRPM4 during ischemia-reperfusion injury involves the increase in both, intracellular calcium and H2O2, which may act together to produce a sustained activation of the channel.
Both TRPM4 and TRPM5 (显示 TRPM5 蛋白) are required for normal responses to bitter, sweet, and umami stimuli.
The findings of this study demonstrated a novel molecular mechanism involving the SUR1 (显示 ABCC8 蛋白)-TRPM4-AQP4 (显示 AQP4 蛋白) complex to account for bulk water influx during astrocyte swelling.
Calcium studies demonstrated that TRPM4 channel negatively regulates calcium entry providing support for activation of the Cn-NFAT (显示 NFATC1 蛋白) pathway in Trpm4 (-/-) mice. Authors provide evidence for the functional expression of TRPM4 channel in response to endurance training.
Study demonstrates that TRPM4 functions as a limiting factor for antigen evoked calcium rise in connective tissue type mast cells and concurrent translocation of TRPM4 into the plasma membrane is part of this mechanism.
Atrial TRPM4 channel is activated by a physiological range of Ca2 (显示 CA2 蛋白)+ concentrations and its excessive activity can cause arrhythmic changes.
electron cryo-microscopy structures of the mouse TRPM4 channel with and without ATP
Disrupting the Trpm4 gene in mice specifically eliminates NMDAR (显示 GRIN1 蛋白)-dependent LTP (显示 SCP2 蛋白).
observations are consistent with a model in which TRPM4 is a regulator of calcium homeostasis in cardiomyocytes after AngII stimulation
The PKC-dependent effect of GLP-1 (显示 GCG 蛋白) on membrane potential and electrical activity was mediated by activation of Na(+)-permeable TRPM4 and TRPM5 (显示 TRPM5 蛋白) channels by mobilization of intracellular Ca(2 (显示 CA2 蛋白)+) from thapsigargin-sensitive Ca(2 (显示 CA2 蛋白)+) stores
The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium. Two transcript variants encoding different isoforms have been found for this gene.
, calcium-activated non-selective cation channel 1
, long transient receptor potential channel 4
, transient receptor potential cation channel subfamily M member 4
, melastatin like 2 protein
, melastatin-like 2
, transient receptor potential ion channel melastatin subgroup member 4
, transient receptor potential cation channel, subfamily M, member 4
, LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily M member 4