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Human Polyclonal SUPT6H Primary Antibody for ChIP, ICC - ABIN4355771
Kronemann, Hagemeier, Cygnar, Phillips, Bresnahan: Binding of the human cytomegalovirus (HCMV) tegument protein UL69 to UAP56/URH49 is not required for efficient replication of HCMV. in Journal of virology 2010
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Human Polyclonal SUPT6H Primary Antibody for IP - ABIN251024
Cygnar, Hagemeier, Kronemann, Bresnahan: The cellular protein SPT6 is required for efficient replication of human cytomegalovirus. in Journal of virology 2012
Altogether, these results indicate that a complex containing LEDGF/p75 (显示 PSIP1 抗体), Iws1, and Spt6 participates in regulating postintegration steps of HIV latency.
identified fibronectin (显示 FN1 抗体), a component of the extracellular matrix and a mesenchymal marker, as a transcriptional target of Pak1 (显示 PAK1 抗体) signaling
Spt6 is a unique histone chaperone capable of regulating the histone epigenetic state of both AID targets and the AID locus.
These results show that intracellular levels of Spt6 are fine-tuned by PAAF1 (显示 PAAF1 抗体) and proteasome, which is required for HIV-1 transcription and extends to cellular genes implicated in cancer.
Abolishing UL69's ability to interact with the SPT6 protein inhibited human cytomegalovirus replication.
Knockdown of Spt6 resulted in severe reduction of class switch recombination in the endogenous Ig locus in B cells.
Reults establish that human Spt6 (hSpt6) is a classic transcription elongation factor (显示 TSFM 抗体) that enhances the rate of RNA polymerase II (显示 Pol II 抗体) elongation.
Biochemical as well as functional experiments revealed that Spt6 could compete for binding of the PRC2 methyltransferase Ezh2 to Suz12 and reduce PRC2 chromatin engagement.
These data indicate that, through cooperation with PolII (显示 Pol II 抗体) and KDM6A (显示 KDM6A 抗体), Spt6 orchestrates removal of H3K27me3, thus controlling developmental gene expression and cell differentiation.
Thus binding of Spt6 to Ser2 (显示 JAG2 抗体)-P RNAPII (显示 Pol II 抗体) provides a cotranscriptional mechanism to recruit Iws1, REF1/Aly (显示 THOC4 抗体), and associated mRNA processing, surveillance, and export factors to responsive genes.
recombinant Spt6 binds selectively to a stretch of uninterrupted consensus repeats located in the N-terminal half of the CTD and recruits Iws1
The elongation factors Pandora/Spt6 and Foggy/Spt5 (显示 SUPT5H 抗体) promote transcription in the zebrafish embryo. (Pandora/Spt6)
Spt6 is essential for the transcriptional response to activation of the Notch (显示 NOTCH1 抗体) pathway.
Acts to stimulate transcriptional elongation by RNA polymerase II (By similarity).
, tat-CT2 protein
, tat-cotransactivator 2 protein
, transcription elongation factor SPT6
, suppressor of Ty 6 homolog
, protein pandora
, suppressor of Ty 6 homolog (S. cerevisiae)
, Spt6 gene product
, SUPT6H,-like protein to suppressor of ty 6
, transcription elongation factor SPT6-like
, hypothetical protein