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When compared with SAP (显示 APCS 蛋白), the other single SH2 domain protein in human, EAT2 shows similar binding energies to unphosphorylated ligands. This is inconsistent to the previous data showing low affinity of EAT2 toward unphosphorylated peptides compared to SAP (显示 APCS 蛋白) which shows high affinity
Data indicate that Ewing's sarcoma-associated transcript-2 (EAT-2) over-expression increased the anti-tumor activity of NK cells against K562 tumor cell. targets.
EAT-2 mediates its effects in natural killer cells by linking SLAM (显示 SLAMF1 蛋白) family receptors to phospholipase Cgamma, calcium fluxes, and Erk (显示 EPHB2 蛋白) kinase.
NTB-A-mediated IFN-gamma production was greatly reduced in the absence of SLAM-associated protein (SAP), demonstrating that cytokine production and cytotoxicity are differentially dependent on SAP and possibly EAT-2
EAT-2 negatively regulates cytokine production in dendritic cells downstream of SLAM (显示 SLAMF1 蛋白) engagement and a genetic polymorphism that disturbs this process promotes the development of lupus.
EAT-2A and EAT-2B act as positive regulators of signaling lymphocyte activation molecule (显示 SLAMF1 蛋白) family receptor-specific NK cell functions in C57BL/6 mice.
Taken together, the data suggest that both EAT-2A and EAT-2B are adapters that recruit Src (显示 SRC 蛋白) kinases to SLAM (显示 SLAMF1 蛋白) family receptors using a mechanism that is distinct from that of SAP (显示 APCS 蛋白).
EAT-2 mediates CRACC (显示 SLAMF7 蛋白) function. In the absence of EAT-2, CRACC (显示 SLAMF7 蛋白) inhibited natural killer cell function.
By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001
, EWS/FLI1-activated transcript 2
, SH2 domain-containing molecule EAT2
, SH2 domain-containing protein 1B
, SH2 domain containing 1B
, SH2 domain protein 1B1