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The chimeric RGS8 domains containing the first or the second exon part of RGS5 (显示 RGS5 蛋白) showed strong inhibitory effects similar to that of wild type RGS8, but the chimeric domain with the third exon part of RGS5 (显示 RGS5 蛋白) lost its activity
Missense mutations in RGS8 gene is associated with breast cancer.
Spinophilin (显示 PPP1R9B 蛋白) was identified as an RGS8-interacting protein.
the crystal structure of RGS8 was determined in complex with Galphaq (显示 GNAQ 蛋白).
ATXN2 (显示 ATXN2 蛋白) interacted selectively with RGS8 mRNA. This interaction was impaired when ATXN2 (显示 ATXN2 蛋白) harbored an expanded polyglutamine. Mutant ATXN2 (显示 ATXN2 蛋白) also reduced RGS8 expression in an in vitro coupled translation
increased miR (显示 MLXIP 蛋白)-150 levels in Spinocerebellar ataxia type 1 Purkinje neurons may modulate disease pathogenesis by targeting the expression of Rgs8 and Vegfa (显示 VEGFA 蛋白).
RGS8 null mutant mice were viable, fertile and showed apparently normal development
This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation.
regulator of G-protein signalling 8