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Hypomethylation of CpG sites in RPTOR (显示 RPTOR ELISA试剂盒), MGRN1 and RAPSN (显示 RAPSN ELISA试剂盒) in blood is associated with breast cancer.
Regulation of Mfn1 (显示 MFN1 ELISA试剂盒) by MGRN1 and the proteasome modulates mitochondrial fusion.
With aging, the neuroprotective e3 ligase MGRN1 relocates from the cytosol to the nucleus of neurons, where it associates with chromatin and potentiates the cellular response to proteotoxic stress. This nuclear shift is due to a proteasome impairment dependent increase of a monoubiquitinated form of MGRN1.
Catalytic inactivation of MGRN1 results in elevated levels of GP78 (显示 AMFR ELISA试剂盒) and a consequential increase in the initiation of mitophagy.
Mahogunin-mediated alpha-tubulin (显示 TUBA4A ELISA试剂盒) ubiquitination via noncanonical K6 linkage regulates microtubule stability and mitotic spindle orientation.
data suggest that MGRN1 selectively targets misfolded proteins for degradation and may exhibit viable therapeutic potential for the treatment of spongiform neurodegeneration
It therefore seems probable that the role of MGRN1 in the adrenal relates to the trafficking and/or degradation of the melanocortin 2 receptor (显示 MC2R ELISA试剂盒).
a role for Mahogunin in a proteasome-independent ubiquitylation pathway: TSG101 (显示 TSG101 ELISA试剂盒) is a specific Mahogunin substrate
Study shows that both (Ctm)PrP and cyPrP can interact with and disrupt the function of Mahogunin (Mgrn), a cytosolic ubiquitin ligase whose loss causes spongiform neurodegeneration.
Mgrn1 can negatively regulate signaling through the Hedgehog (显示 SHH ELISA试剂盒) pathway by reducing cell-surface and ciliary levels of Smoothened, an oncoprotein that transmits the Hedgehog (显示 SHH ELISA试剂盒) signal across the membrane.
Findings suggest that mahogunin ring finger-1 contributes to the clearance of toxic mutant copper-zinc superoxide dismutase (显示 SOD1 ELISA试剂盒) inclusions likely through autophagic pathway.
ATRN (显示 ATRN ELISA试剂盒) also has no effect on prion (显示 PRNP ELISA试剂盒) disease onset or progression and discuss possible mechanisms that could cause vacuolation of the central nervous system in Mgrn1 and Atrn (显示 ATRN ELISA试剂盒) null mutant mice
pigment-type switching likely requires MGRN1's ubiquitin ligase activity but not its ability to bind TSG101 or NEDD4.
Levels of the Mahogunin Ring Finger 1 E3 ubiquitin ligase do not influence prion (显示 PRNP ELISA试剂盒) disease.
the md and mg mutations rescue the A(y) phenotypes by a primarily cAMP-independent mechanism promoting trafficking of MC4R and likely MC1R away from the lysosome toward the cell surface.
positional cloning of mahoganoid, encoding a novel 494-amino acid protein containing a C3HC4 RING (really interesting new gene) domain that may function as an E3 ubiquitin ligase
a null mutation for mahoganoid causes a similar age-dependent neuropathology that includes many features of prion (显示 PRNP ELISA试剂盒) diseases but without accumulation of protease-resistant prion protein (显示 PRNP ELISA试剂盒)
Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro.
E3 ubiquitin-protein ligase MGRN1
, RING finger protein 156
, mahogunin RING finger protein 1
, mahogunin, ring finger 1
, probable E3 ubiquitin-protein ligase MGRN1
, mahogunin ring finger protein 1