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DeltaNp73 was abundantly expressed in the atopic dermatitis epidermis and increased the release of TSLP (显示 TSLP 蛋白) via NF-kappaB (显示 NFKB1 蛋白) activation.
PRIMA-1 (显示 PRIMA1 蛋白) could cause the demethylation of TP73, through DNMT1 (显示 DNMT1 蛋白) depletion, to subsequently enhance the unfolded protein response
Data found that P73 G4C14-to-A4T14 polymorphism was significantly associated with non-small cell lung cancer risk in Chinese population.
In p53 (显示 TP53 蛋白)-deficient breast cancers, compensatory mechanism of NFkB repression by p63 (显示 RPE65 蛋白) and p73 during genotoxic stress could lead to complex effects that would influence all aspects of tumor progression.
DeltaNp73 had no leukemic transformation capacity by itself and apparently did not cooperate with the PML (显示 PML 蛋白)/RARA (显示 RARA 蛋白) fusion protein to induce a leukemic phenotype in a murine BM transplantation model.
In colorectal tumor cells RPL26 (显示 RPL26 蛋白) regulates p73 expression via two distinct mechanisms: protein stability and mRNA translation.
Data show that a dominant-negative effect is widely spread within the p53 (显示 TP53 蛋白)/p63 (显示 RPE65 蛋白)/p73 family as all p53 (显示 TP53 蛋白) loss-of-function hotspot mutants and several of the isoforms of p53 (显示 TP53 蛋白) and p73 tested exhibit a dominant-negative potential.
p73 supports mitochondria respiration in medulloblastoma via regulation of glutamine metabolism
Study suggests that the cleavage of p73 on specific sites may release its pro-apoptotic function and contribute to cell death in breast cancer.
the transactivation inhibitory (TI) domains within the alpha-isoform-specific C termini of p63 (显示 RPE65 蛋白) and p73 are essential for binding to p53R175H.
p73 is required for appropriate BMP-induced mesenchymal-to-epithelial transition during somatic cell reprogramming.
P73 (显示 ARHGAP24 蛋白) role in differentiating stem cells.RASSF1A promotes a YAP (显示 YAP1 蛋白)-p73 (显示 ARHGAP24 蛋白) transcriptional programme that enables differentiation.
Absence of TAp73 leads to activation of TGF-beta (显示 TGFB1 蛋白) signaling through a Sma (显示 ACTA2 蛋白) and Mad-related proteins-independent pathway, favoring oncogenic transforming growth factor-beta effects and epithelial-to-mesenchymal transition.
Findings reinforce the role of TAp73 as tumor suppressor gene and indicate that the regulation of cellular metabolism by TAp73 contributes to its tumor suppressor function.
cells expressing both p63 (显示 CKAP4 蛋白) and p73 (显示 ARHGAP24 蛋白) exist in mouse epidermis and hair follicle and that hetero-tetramer complexes can be detected by immunoprecipitation in differentiating keratinocytes.
both p53 (显示 TP53 蛋白) and p73 (显示 ARHGAP24 蛋白) are critical in apoptosis induced by DNA damage and differentiation.
New function of p73 (显示 ARHGAP24 蛋白), independent of p53 (显示 TP53 蛋白), in the neurogenic architecture of the SVZ of rodent brain.
these results therefore highlight an unanticipated role for p53 (显示 TP53 蛋白) family proteins in a regulatory network that integrates essential Wnt (显示 WNT2 蛋白)-Tcf (显示 HNF4A 蛋白) and nodal-Smad (显示 SMAD1 蛋白) inputs.
TAp73 as necessary and sufficient for basal body docking, axonemal extension, and motility during the differentiation of Motile multiciliated cell progenitors.
p73 (显示 ARHGAP24 蛋白) drives multiciliogenesis, both through transcriptional activation of a master ciliogenesis transcription factor FoxJ1 (显示 FOXJ1 蛋白) and through regulation of multiple genes central to ciliogenesis.
This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined.
transformation related protein 73
, tumor protein p73
, tumor protein p73-like
, p53-like transcription factor
, p53-related protein