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During neural tube formation Rab11-positive recycling endosomes distribute to the medial apical cell junctions in the neural plate. Polarization was under the control of planar cell polarity signalling, and was necessary for neural plate folding.
Rab11 and the associated motor protein Myosin V (显示 MYO5A 蛋白) play essential roles in both endogenous and ectopic apical constriction, and might be involved in Vangl2 trafficking to the cell surface.
Rab11 expression is required throughout the early embryo for proper left-right patterning.
A requirement for Rab11 in multiciliated cells(MCC (显示 MCC 蛋白)) development and support a two-step model, in which the initial polarization of MCC (显示 MCC 蛋白) precursors is critical for their integration into the superficial cell layer.
Pard3 (显示 PARD3 蛋白) and Rab11a are necessary for lumen formation in the neural rod.
The established transgenic lines ubiquitously express EGFP fusions of Rab5c (显示 Rab5c 蛋白) (early endosomes), Rab11a (recycling endosomes), and Rab7 (显示 RAB7A 蛋白) (late endosomes) to study localization and dynamics during development.
The results suggest that Rab11 regulates anterograde transport from the TGN to the plasma membrane and strongly implicate SYP122, rather than SYP121.
This review will focus on the structure and function of the novel Rab11-FIP3-Rabin8 dual effector complex and its implications for the targeting of sensory receptors to primary cilia, dysfunction of which causes cilia defects underlying human diseases and disorders know as ciliopathies.
Data suggest that membrane tethering mediated by endosomal RAB11A is drastically and selectively stimulated by its cognate Rab effectors, class V myosins (MYO5A and MYO5B), in a GTP-dependent manner. (RAB11A = ras-related GTPase Rab-11A; MYO5 = myosin class V)
these studies are not only the first to identify alpha4 helix of Rab11a as a protein binding domain on the GTPase but also reveal novel mechanistic insights into the intracellular trafficking of the hIP, and potentially of other members of the GPCR superfamily, involving Rab11-dependent mechanisms
transient expression of ATG16L1 not only inhibited autophagosome biogenesis, but also aberrantly targeted RAB11-positive recycling endosomes, resulting in recycling endosome aggregates.
The results from this analysis indicated that Rab11a, Rab11c(Rab25 (显示 RAB25 蛋白)) and Rab14 (显示 RAB14 蛋白) were expressed in a wide range of cell lines, including the human placental trophoblastic BeWo cell line.
The results suggest that progressive assembly of vRNA segments may be cell type dependent and that vRNA may be transported through the cytoplasm without Rab11A-containing recycling endosomes in the absence of intact microtubules.
Rac1-Rab11-FIP3 regulatory hub coordinates vesicle traffic with actin remodeling and T-cell activation
In colorectal carcinoma, overexpression of Rab11 was found to promote collective cell migration through the increased distribution of E-cadherin (显示 CDH1 蛋白), which enhanced cell-cell connections.
A novel tribasic Golgi export signal directs cargo protein interaction with activated Rab11 and AP-1 (显示 FOSB 蛋白)-dependent Golgi-plasma membrane trafficking.
Analysis reveals novel aspects of the PI4KIIIb-Rab11 complex, specifically conformational changes induced in the switch regions of activated Rab11.
The authors determined crystal structures of MyoVa (显示 MYO5A 蛋白)-globular tail domain bound either to the Spir-2 (显示 SPIRE2 蛋白) motif or to Rab11 and show that a Spir-2 (显示 SPIRE2 蛋白):MyoVa:Rab11 complex can form.
Rab11a inactivation in macrophages as a result of apoptotic cell binding initiates phagocytosis of apoptotic neutrophils via the modulation of ADAM17 (显示 ADAM17 蛋白)-mediated CD36 (显示 CD36 蛋白) cell surface expression
Rab8a (显示 RAB8A 蛋白) and Rab11a Are Dispensable for Rhodopsin (显示 RHO 蛋白) Transport in Mouse Photoreceptors
The up-regulation of Rab11, Rab7 (显示 RAB7A 蛋白), or RILP (显示 RILP 蛋白), but not its truncated form RILP (显示 RILP 蛋白)-C33 (显示 CD82 蛋白), rescued LAMP2A-defective trafficking in cystinosis, whereas dominant-negative Rab11 or Rab7 (显示 RAB7A 蛋白) impaired LAMP2A trafficking.
Rab11a/Rab11 family-interacting protein 2 (显示 RAB11FIP2 蛋白)-mediated VE-cadherin (显示 CDH5 蛋白) recycling is required for formation of adherens junctions and restoration of vascular endothelial barrier integrity.
Rab11a-knockdown cells displayed mislocalization of STX3 (显示 STX3 蛋白) and the presentation of microvilli in the basolateral compartment
Results define Glut3 to be a rab11-dependent trafficking cargo and suggest that impaired Glut3 trafficking arising from rab11 dysfunction underlies the glucose hypometabolism observed in Huntington's disease
LMTK1 (显示 AATK 蛋白) negatively controls dendritic formation by regulating Rab11A-positive endosomal trafficking.
Rab11a critically controls mouse blastocyst development and soluble matrix metalloproteinase secretion
Thus, Rab11a endosome controls intestinal host-microbial homeostasis at least partially via sorting Toll (显示 TLR4 蛋白)-like receptors, including Tlr9 (显示 TLR9 蛋白).
Rab11a promotes Porcine reproductive and respiratory syndrome virus (PRRSV) replication and associates with PRRSV replication sites.
The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isoforms have been found for this gene.
RAB11A, member RAS oncogene family
, ras-related protein Rab-11A
, Rab11 GTPase
, rab11A protein
, Rab11a, GTPase
, rab11A, RAB family GTPase
, RAB 11A, member oncogene family
, rab11 GTP-binding protein
, tubulovesicle-associated protein