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Both CLU (显示 CLU 抗体) and PLXNA4 have been genetically associated with Alzheimer disease (AD) risk and our data thus provide a direct relationship between two AD risk genes. Our data suggest that increasing the levels of PLXNA4 or targeting CLU (显示 CLU 抗体)-PLXNA4 interactions may have therapeutic value in AD.
Data indicate that plexin A1 (显示 PLXNA1 抗体)-4 (PLXNA1 (显示 PLXNA1 抗体)-4) mediation of neuroanatomical traits can be detected using in vivo neuroimaging techniques.
There is a significant association between Alzheimer's disease risk and SNPs in PLXNA4.
Rare variants in PLXNA4 and Parkinson's disease.
Plexin-A4 promotes tumor progression and tumor angiogenesis by enhancement of VEGF (显示 VEGFA 抗体) and bFGF (显示 FGF2 抗体) signaling.
These findings implicate Semaphorin-6A (显示 SEMA6A 抗体) - Plexin-A2 (显示 Plxna2 抗体)/Plexin-A4 interactions in dorsal lateral geniculate nucleus axon guidance and in the spatiotemporal organization of guidepost cell populations in the mammalian subpallium.
These findings suggest that by interacting with PlexA4, TrkA (显示 NTRK1 抗体) plays a crucial role in redirecting local Sema3A (显示 SEMA3A 抗体) signaling to retrograde axonal transport, thereby regulating dendritic GluA2 (显示 GRIA2 抗体) localization and patterning.
Distinct cytoplasmic domains in Plexin-A4 mediate diverse responses to semaphorin 3A (显示 SEMA3A 抗体) in developing mammalian neurons.
results suggest that Plexin-A4 is involved in the precise positioning of oligodendrocyte precursor cells in developing cerebral cortex.
null mutations in Sema6A (显示 SEMA6A 抗体) or PlexinA4 (PlexA4) exhibit a pronounced defect in OPL (显示 ZIC1 抗体) stratification of horizontal cell axons without any apparent deficits in bipolar cell dendrite or photoreceptor axon targeting.
Findings suggest plexin-A4 and Sema3A (显示 SEMA3A 抗体) as new intervention points for treating sepsis.
suggesting that a Semaphorin6A-Plexin-A4 cis (显示 CISH 抗体) interaction serves as an inhibitory mechanism.
plexin-A4 was expressed in the developing nervous system with a pattern different to that of other members of the plexin-A subfamily (plexin-A1 (显示 PLXNA1 抗体), plexin-A2 (显示 Plxna2 抗体) and plexin-A3 (显示 PLXNA3 抗体))
PlexA4 expressed in oligodendrocyte precursor cells acts as a mediator of semaphorin signals
Involved in the development of primary sensory neurons especially in branching of the peripheral axons. Interacts with the SLIT2 signaling specifically to promote axonal branching of Rohon-Beard neurons and the trigeminal sensory ganglion neurons.
, plexin A4, A
, plexin A4
, putative plexin 2