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Human Netrin 1 Protein expressed in HEK-293 Cells - ABIN1344145
Rama, Goldschneider, Corset, Lambert, Pays, Mehlen: Amyloid precursor protein regulates netrin-1-mediated commissural axon outgrowth. in The Journal of biological chemistry 2012
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Human Netrin 1 Protein expressed in HEK-293 Cells - ABIN1344382
Ozmadenci, Féraud, Markossian, Kress, Ducarouge, Gibert, Ge, Durand, Gadot, Plateroti, Bennaceur-Griscelli, Scoazec, Gil, Deng, Bernet, Mehlen, Lavial: Netrin-1 regulates somatic cell reprogramming and pluripotency maintenance. in Nature communications 2015
our data suggest that netrin-1 contributes to the migration of the neural folds towards the midline
Partial knock down of netrin-1 confirms that this chemoattractive ligand of neogenin (显示 NEO1 蛋白) acts in the same early forming dorsoventral brain pathway.
Studies identify netrin-1 as an active participant in retinal ganglion cell axon presynaptic differentiation, not only as they navigate along their pathway but also at their target.
increased concentrations of urinary SEMA (显示 SEMA3B 蛋白)-3A and urinary Netrin-1 are found in urine from children with severe hydronephrosis and that their concentrations are related to the degree of obstruction.
Conclusion RBP4 (显示 POLR2D 蛋白) may be used as a predictive factor of diabetic nephropathy patients complicated with silent cerebral infarction (SCI) and is positively correlated with cognitive dysfunction. RBP4 (显示 POLR2D 蛋白)/Lp-PLA2 (显示 Lp-PLA2 蛋白)/Netrin-1 pathway activation may be one of the occurrence mechanisms in diabetic nephropathy complicated with SCI.
Netrin-1 decreased in experimental autoimmune encephalomyelitis and in multiple sclerosis patients, mainly during relapse, suggesting an anti-inflammatory role of netrin-1
Such data indicate that cooperation between the UPR and UNC5A (显示 UNC5A 蛋白) depletion as previously observed by ourselves in HCC (显示 FAM126A 蛋白) patients samples may foster liver cancer development and growth.
Netrin-1 restores cell injury and impaired angiogenesis in vascular endothelial cells upon high glucose via PI3K (显示 PIK3CA 蛋白)/AKT (显示 AKT1 蛋白)-eNOS (显示 NOS3 蛋白) signaling.
Collectively, our results defined netrin-1 as a positive regulator of malignant tumor metastasis in GC by activating the YAP (显示 YAP1 蛋白) signaling, with potential implications for new approaches to GC therapy.
Results demonstrate that NTN1 is an important regulator of stemness and motility of glioblastoma cells. Furthermore, it deciphers a novel mechanism where NTN1 activates Notch (显示 NOTCH1 蛋白) signaling and subsequent stemness in invasive glioblastoma cells.
Three mutations in exon 7 of NTN1 in 2 unrelated families and 1 sporadic case with isolated congenital mirror movements (CMM), a disorder characterized by involuntary movements of one hand that mirror intentional movements of the opposite hand.
Netrin-1 acts as a non-canonical angiogenic factor (显示 VEGFA 蛋白) produced by human Wharton's jelly mesenchymal stem cells.
Our study has shown an increase in netrin-1 expression that could be linked with macrophage infiltration and polarization in the epicardial adipose tissue of patients with coronary artery disease
potential effect of Ntn-1 on angiogenesis is further verified by the mouse hindlimb ischemia model, where the pre-activation of hUCB-MSCs with Ntn-1 significantly improved vascular regeneration. These results demonstrate that Ntn-1 plays an important role in the tissue regeneration process of hUCB-MSC (显示 MSC 蛋白) via the lipid raft-mediated Inalpha6beta4 signaling pathway.
Using a Ntn1 conditional knockout, we show that netrin 1, which is released at the pial surface by ventricular zone progenitors is responsible for the CNS confinement of precerebellar neurons.
Data indicate that the formation of the hypothalamic NPY (显示 NPY 蛋白) neural network is regulated at least partly by Netrin-1 signalling during normal in utero brain development in the mouse.
Our findings suggest that netrin-1 can suppress the growth of PDAC and provide a mechanistic insight into this suppression.
Diabetes decreases aortic levels of netrin-1. However, overexpression of netrin-1 attenuates diabetes-induced VED and limits the reduction of NO levels, while increasing expression of p-ERK1/2, and suppressing oxidative stress and inflammatory and apoptotic processes
Ntn1 may play divergent cellular roles despite its conserved expression during canal morphogenesis in chicken and mouse.
netrin-1 degradation products are capable of modulating vascular permeability in diabetic retinopathy
Blockade of Netrin-1/Unc5b (显示 UNC5B 蛋白) by monoclonal antibodies prevents bone destruction and reduces the severity of K/BxN serum transfer-induced arthritis
Results suggest that Netrin1/DCC (显示 DCC 蛋白) signaling induce neuronal migration in the dorsal spinal cord.
Treatment with endogenous anti-inflammatory protein netrin-1 reduces pulmonary inflammation during the initial stages of acute lung injury.
Netrin-1 could be important for follicular function in the swine.
findings show that the netrin-1 and p53RDL1 (显示 UNC5B 蛋白) system may regulate the induction of apoptosis in porcine granulosa cells
Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined\; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development.
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, netrin 1, mouse, homolog of