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Human Netrin 1 Protein expressed in HEK-293 Cells - ABIN1344145
Rama, Goldschneider, Corset, Lambert, Pays, Mehlen: Amyloid precursor protein regulates netrin-1-mediated commissural axon outgrowth. in The Journal of biological chemistry 2012
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Human Netrin 1 Protein expressed in HEK-293 Cells - ABIN1344382
Ozmadenci, Féraud, Markossian, Kress, Ducarouge, Gibert, Ge, Durand, Gadot, Plateroti, Bennaceur-Griscelli, Scoazec, Gil, Deng, Bernet, Mehlen, Lavial: Netrin-1 regulates somatic cell reprogramming and pluripotency maintenance. in Nature communications 2015
These in vivo findings reveal an important role for netrin in the early growth and guidance of vertebrate central neuron dendritic arbors
our data suggest that netrin-1 contributes to the migration of the neural folds towards the midline
Partial knock down of netrin-1 confirms that this chemoattractive ligand of neogenin acts in the same early forming dorsoventral brain pathway.
Studies identify netrin-1 as an active participant in retinal ganglion cell axon presynaptic differentiation, not only as they navigate along their pathway but also at their target.
the current data suggest that netrin-1 can act as a pro-metastatic factor in NSCLC by enhancing cell invasion, migration, and VM via PI3K/AKT and ERK-mediated EMT process, thereby implicating netrin-1 as a novel promising therapeutic target against aggressive non-small cell lung cancer.
Four genes-ACT1, PIN1, DNMT1 and NTN1-emerged as having roles in pathways that may influence Primary Biliary Cholangitis pathogenesis in British Columbia First Nations people.
netrin-1 as a major signal that mediates the dynamic crosstalk between inflammation and chronic erosion of the extracellular matrix in Abdominal aortic aneurysm, is reported.
This study implicates DCC and NTN1 mutations in the pathophysiology of CHH consistent with the role of these two genes in the ontogeny of GnRH neurons in mice.
High NTN1 expression is associated with gastric cancer.
increased concentrations of urinary SEMA-3A and urinary Netrin-1 are found in urine from children with severe hydronephrosis and that their concentrations are related to the degree of obstruction.
miR214 reduces chemoresistance by targeting netrin1 in bladder cancer cell lines.
Conclusion RBP4 may be used as a predictive factor of diabetic nephropathy patients complicated with silent cerebral infarction (SCI) and is positively correlated with cognitive dysfunction. RBP4/Lp-PLA2/Netrin-1 pathway activation may be one of the occurrence mechanisms in diabetic nephropathy complicated with SCI.
Netrin-1 decreased in experimental autoimmune encephalomyelitis and in multiple sclerosis patients, mainly during relapse, suggesting an anti-inflammatory role of netrin-1
Such data indicate that cooperation between the UPR and UNC5A depletion as previously observed by ourselves in HCC patients samples may foster liver cancer development and growth.
Netrin-1 restores cell injury and impaired angiogenesis in vascular endothelial cells upon high glucose via PI3K/AKT-eNOS signaling.
Collectively, our results defined netrin-1 as a positive regulator of malignant tumor metastasis in GC by activating the YAP signaling, with potential implications for new approaches to GC therapy.
Results demonstrate that NTN1 is an important regulator of stemness and motility of glioblastoma cells. Furthermore, it deciphers a novel mechanism where NTN1 activates Notch signaling and subsequent stemness in invasive glioblastoma cells.
Three mutations in exon 7 of NTN1 in 2 unrelated families and 1 sporadic case with isolated congenital mirror movements (CMM), a disorder characterized by involuntary movements of one hand that mirror intentional movements of the opposite hand.
Netrin-1 acts as a non-canonical angiogenic factor produced by human Wharton's jelly mesenchymal stem cells.
Our study has shown an increase in netrin-1 expression that could be linked with macrophage infiltration and polarization in the epicardial adipose tissue of patients with coronary artery disease
netrin-1 degradation products are capable of modulating vascular permeability in diabetic retinopathy
NETRIN1 signaling pathway is identified as a candidate pathway for major depressive disorder and should be explored in further large population studies.
Enhanced detection of netrin-1-expressing CD14(low) cells in patients with systemic sclerosis-related interstitial lung disease was observed, and antibody-mediated netrin-1 neutralization attenuated detection of fibrocytes in all settings.
we review the Netrin-1 mediated regulation of cancer, its potential use as a biomarker, and the targeting of the Netrin-1 pathway to treat cancers
this work establishes a novel role for MARCKS in axon dynamics and highlights the necessity of MARCKS as an organizer of DCC signaling at the membrane.
potential effect of Ntn-1 on angiogenesis is further verified by the mouse hindlimb ischemia model, where the pre-activation of hUCB-MSCs with Ntn-1 significantly improved vascular regeneration. These results demonstrate that Ntn-1 plays an important role in the tissue regeneration process of hUCB-MSC via the lipid raft-mediated Inalpha6beta4 signaling pathway.
Using a Ntn1 conditional knockout, we show that netrin 1, which is released at the pial surface by ventricular zone progenitors is responsible for the CNS confinement of precerebellar neurons.
Data indicate that the formation of the hypothalamic NPY neural network is regulated at least partly by Netrin-1 signalling during normal in utero brain development in the mouse.
Our findings suggest that netrin-1 can suppress the growth of PDAC and provide a mechanistic insight into this suppression.
Diabetes decreases aortic levels of netrin-1. However, overexpression of netrin-1 attenuates diabetes-induced VED and limits the reduction of NO levels, while increasing expression of p-ERK1/2, and suppressing oxidative stress and inflammatory and apoptotic processes
Ntn1 may play divergent cellular roles despite its conserved expression during canal morphogenesis in chicken and mouse.
netrin1 provides "hederal" boundaries: a local growth substrate that promotes axon extension, while also preventing local innervation of netrin1-expressing domains.
Blockade of Netrin-1/Unc5b by monoclonal antibodies prevents bone destruction and reduces the severity of K/BxN serum transfer-induced arthritis
Results suggest that Netrin1/DCC signaling induce neuronal migration in the dorsal spinal cord.
results show that the classical view that attraction of commissural axons is mediated by a gradient of floor-plate-derived netrin-1 is inaccurate and that netrin-1 primarily acts locally by promoting growth cone adhesion.
Here, we report that dissociation of UNC5C and polymerized TUBB3, the highly dynamic beta-tubulin isoform in neurons, is essential for netrin-1/UNC5C-promoted axon repulsion. These results not only provide a working model of direct modulation of MTs by guidance cues in growth cone navigation but also help us to understand molecular mechanisms underlying developmental brain disorders associated with TUBB3 mutations.
Netrin1 does not act as a long-range secreted chemoattractant for commissural spinal axons but instead promotes ventrally directed axon outgrowth by haptotaxis, i.e., directed growth along an adhesive surface.
Netrin-1(+/-) mice were protected against bleomycin-induced lung fibrosis and fibrocyte accumulation.
Netrin-1 enhanced insulin secretion by promoting beta-cell Ca(2+) influx and cAMP production.
netrin 1 treatment prevented bone erosion in an autoimmune arthritis model and age-related bone destruction.
Netrin-1 reduced the Abeta1- 40-induced Abeta1-42 increase, increased sAbetaPPalpha, and reversed the Abeta-induced sAbetaPPalpha decrease in vitro; in vivo, induction of netrin-1 expression in PDAbetaPPSwe/Ind transgenic mice resulted in reductions in both Abeta1-42 and Abeta1- 40, and ICV delivery of netrin-1 to PDAbetaPPSwe/Ind mice increased sAbetaPPalpha, decreased Abeta, and improved working memory.
Treatment with endogenous anti-inflammatory protein netrin-1 reduces pulmonary inflammation during the initial stages of acute lung injury.
Netrin-1 could be important for follicular function in the swine.
findings show that the netrin-1 and p53RDL1 system may regulate the induction of apoptosis in porcine granulosa cells
Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined\; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development.
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