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bilateral lineup in the trunk before PGC migration colonizing gonadal areas is defective in PGCS expressing a missense mutation in chemokine receptor gene cxcr4b
The down-regulation of CXCR4 by inducing small interfering RNA inhibits the proliferation of Th17 cells and to promote the expression of IL-6 (显示 IL6 蛋白), IL-17 (显示 IL17A 蛋白), and IL-23 (显示 IL23A 蛋白).
superparamagnetic iron oxide nanoparticles also stimulated CXCR4 (C-X-C chemokine receptor type 4) expression and CXCR4-SDF-1 (Stromal cell-derived factor 1 (显示 CXCL12 蛋白)) signaling in mesenchymal stem cells.
Results indicate that exosomes secreted from highly metastatic hepatocarcinoma-F cells promote Hca-P with (low metastatic potential) cell migration and invasion possibly through horizontal transfer of CXCR4. The exosomal CXCR4 released from Hca-F cells stimulate LECs proliferation and lymphangiogenesis, this probably is due to SDF-1alpha/CXCR4 axis mediated MMP-9 (显示 MMP9 蛋白), MMP-2 (显示 MMP2 蛋白) and VEGF-C (显示 VEGFC 蛋白) secretions.
findings suggest that periodontal CXCR4 signaling in several cell types in Porphyromonas gingivalis-induced periodontal inflammation depresses alveolar bone resorption in periodontitis. CXCR4 signaling might be a target for therapeutic intervention to prevent alveolar bone resorption in periodontitis
CXCL12 (显示 CXCL12 蛋白)-CXCR4 signalling is essential for the correct patterning of aortic arches and pulmonary arteries during development.
Study demonstrates that CXCR4/CXCL12 (显示 CXCL12 蛋白) axis can limit oxidative stress injury in hematopoietic stem cells (HSCs) by reducing mitochondrial oxidative stress. Disruption of CXCR4 receptor in mice leads to increased endogenous production of reactive oxygen species, resulting in p38 MAPK (显示 MAPK14 蛋白) activation, increased DNA double-strand breaks and apoptosis leading to marked reduction in HSC (显示 FUT1 蛋白) repopulating potential.
the Sdf-1 (显示 CXCL12 蛋白) receptors - Cxcr4 and Cxcr7 (显示 CXCR7 蛋白), as well as signaling pathways induced by these molecules in primary myoblasts, as well as various stem cells, were studied.
Results provide evidence showing that CXCR4 plays an important role in regulating biological functions associated with B16 liver metastasis.
Using an RNA-mediated interference screen, we identified phospholipase Cepsilon 1 (PLCepsilon1) as a crucial regulator of stromal cell-derived factor 1 alpha (SDF-1alpha)-induced Rap1 activation. We have shown that SDF-1alpha-induced activation of Rap1 is transient in comparison with the sustained level following cross-linking of the antigen receptor.
Cardiac stem cells express CXCR4. Activation of c-kit signalling by SCF (显示 KITLG 蛋白) promotes migration of CSCs with increased phosphorylation of CXCR4-serine 339, p38 mitogen-activated protein kinase (p38 MAPK (显示 MAPK14 蛋白)) and extracellular regulated protein kinases 1/2 (ERK1/2).
CXCR4 is highly abundant in the zona glomerulosa and in aldosterone producing adenomas suggesting a significant role in adrenocortical physiology and further representing a potential target for molecular imaging of aldosterone-producing tissue.
High CXCR4 expression is associated with bladder cancer progression.
The overexpression of CXCR4 increased sVCAM1, and the sVCAM1 secreted from CXCR4-overexpressing non-small cell lung carcinoma cells recruited and arrested additional osteoclast progenitors to promote osteoclastogenesis.
MiR (显示 MLXIP 蛋白)-125b functions as an important downstream mediator upon the activation of CXCL12 (显示 CXCL12 蛋白)/CXCR4 axis.
Data suggest that CXCL12 and its receptor CXCR4 are critical in maintaining homeostasis, specifically during hematopoiesis. Present clinical trials (especially in hematological tumors) are testing whether adding CXCR4 inhibitors to impair tumor dissemination will increase effectiveness of ongoing anti-cancer treatments. (CXCL12 = C-X-C motif chemokine ligand 12; CXCR4 = C-X-C motif chemokine receptor-4) [REVIEW]
hypoxiainduced expression of CXCR4 promoted trophoblast cell migration and invasion via the activation of HIF1alpha (显示 HIF1A 蛋白), which is crucial during placentation.
CXCR4 expression was up-regulated in NSCLC cell lines. Inhibition of CXCR4 may reduce EMT (显示 ITK 蛋白), invasion and migration of NSCLC cells.
results suggest that BCP (显示 OPN1SW 蛋白)-ALL cells create a leukemic niche that attracts leukemic cells in a CXCR4/CXCL12 (显示 CXCL12 蛋白)-independent manner
Serum CXCR4 and CXCL12 (显示 CXCL12 蛋白) levels increase significantly in septic neonates and they are valuable marker in diagnosis of neonatal sepsis. Serum concentrations of both chemokines represent promising novel biomarkers for neonatal sepsis.
study provides atomistic-level description of the activation dynamics of the C-X-C chemokine receptor type 4 (CXCR4), a class A GPCR (显示 NMUR1 蛋白) and important drug target
CXCR4 controls leukocyte mobilization after trauma.
The new method has shown to be capable of promoting CSCs proliferation and differentiation into cardiomyocytes through activating the SDF-1 (显示 CXCL12 蛋白)/CXCR4 axis, while inhibiting myocardial apoptosis , thereby enhancing myocardial regeneration.
reports transmural and perivascular expression patterns of chemokines CCL2 (显示 CCL2 蛋白) and CXCL2 (显示 CXCL2 蛋白) and of chemokine (显示 CCL1 蛋白) receptors CCR2 (显示 CCR2 蛋白), CCR5, and CXCR4 following coronary angioplasty
The current analysis failed in identifying a causal mutation on the CXCR4 gene underlying a previously reported quantitative trait loci for cattle trypanotolerance on bovine chromosome 2.
There is a potential link between follicular SDF1 (显示 CXCL12 蛋白)/CXCR4 activation and the regulation of ovulation-related genes in cows and horses.
The combination of low expression of CXCR4 and high expression of IL-10 (显示 IL10 蛋白) might be closely concerned with some bias for the production of PI calves.
The increased CXCR4 and CXCR7 (显示 CXCR7 蛋白) expression resulted in increased SDF-1 (显示 CXCL12 蛋白)-induced RF/6A cell migration and tube formation.
The CXCR7 (显示 CXCR7 蛋白)/CXCR4/CXCL12 (显示 CXCL12 蛋白) axis plays an important role in the formation of CNV, and may become a novel target for the treatment of choroidal neovascularization-associated diseases.
These findings suggest that FBLN5 (显示 FBLN5 蛋白) may interfere with choroidal neovascularization by downregulating VEGF (显示 VEGFA 蛋白), CXCR4, and TGFB1 (显示 TGFB1 蛋白) expression and inhibiting choroidl endothelial cell proliferation.
Virus recovered from CA28 plasma (SHIV(CA28NP)) used both CCR5 and CXCR4 for entry, but the virus recovered from lymph node (SHIV(CA28NL)) used CXCR4 almost exclusively
Arteries are formed by vein-derived endothelial tip cells, this process critically depends on chemokine receptor Cxcr4 function.
SDF1a (显示 CXCL12 蛋白) directly controls the migration of both leading and trailing edges of a tissue through the activation of two independent receptors, CXCR4b and CXCR7 (显示 CXCR7 蛋白).
Hoxb8a is induced by and cooperates with Wnt (显示 WNT2 蛋白) signaling to up-regulate cxcr4b, and acts through multiple mechanisms to repress cxcr7b expression.
Expression of Cxcr4 and Cxcl12 (显示 CXCL12 蛋白) in radial glial cells of the adult zebrafish brain supports important roles for the Cxcl12 (显示 CXCL12 蛋白)/Cxcr4 pair in brain development and functioning.
show that inactivation of the estrogen receptor ESR1 (显示 ESR1 蛋白) results in ectopic expression of cxcr4b throughout the primordium, whereas ESR1 (显示 ESR1 蛋白) overexpression results in a reciprocal reduction in the domain of cxcr4b expression.
Study suggest that the Cxcl12a-Cxcr4b ligand-receptor pair are involved in the migration of GnRH3 neurons in zebrafish, and are therefore crucial for the development of this system.
A CXCR4-like chemokine receptor is expressed by the migrating lateral line primordium cells. Both the formation and the innervation of this system depend on the SDF1 (显示 CXCL12 蛋白)-CXCR4 system.
Knocking down CXCR4 results in severe defects in primordial germ cell migration.
SDF-1 (显示 CXCL12 蛋白)/CXCR4 signaling is important for guiding retinal ganglion cell axons within the retina to the optic stalk to exit the retina.
chemokine (显示 CCL1 蛋白) signaling contributes to both the olfactory placode assembly and the olfactory sensory neurons axon pathfinding in zebrafish
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
C-X-C chemokine receptor type 4
, SDF-1 receptor
, Stromal cell-derived factor 1 receptor
, chemokine (C-X-C motif) receptor 4
, chemokine (C-X-C) receptor 4
, chemokine receptor 4
, leukocyte-derived seven transmembrane domain receptor
, leukocyte-expressed seven-transmembrane-domain
, pre-B-cell-derived chemokine receptor
, stromal cell-derived factor 1 receptor
, CXC chemokine receptor
, chemokine receptor (LCR1)
, CD184 antigen
, leukocyte-derived seven-transmembrane-domain receptor
, lipopolysaccharide-associated protein 3
, neuropeptide Y receptor Y3
, seven transmembrane helix receptor
, seven-transmembrane-segment receptor, spleen
, C-X-C chemokine receptor type 4-B
, SDF-1 receptor B
, SDF-1 receptor-B
, Stromal cell-derived factor 1 receptor-B
, stromal cell-derived factor 1 receptor B
, chemokine receptor CXCR4
, CXC chemokine receptor 4