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bilateral lineup in the trunk before PGC migration colonizing gonadal areas is defective in PGCS expressing a missense mutation in chemokine receptor gene cxcr4b
Hyaluronic acid-laminin hydrogels increase neural stem cell transplant retention and migratory response to SDF-1alpha in a manner critically dependent on signaling via the SDF-1alpha-CXCR4 axis.
The Function of SDF-1-CXCR4 Axis in SP Cells-Mediated Protective Role for Renal Ischemia/Reperfusion Injury by SHH/GLI1-ABCG2 Pathway
the pivotal role of CXCR4- and CXCR7 (显示 CXCR7 蛋白)-inhibition in acute pulmonary inflammation, which depended on A2B (显示 ADORA2B 蛋白)-receptor signaling, is reported.
CXCR4 signaling is critical for perivascular invasion of GBM cells and radiation sensitivity.
The results provide the first evidence that upregulation of TGFb (显示 TGFB1 蛋白)/Smad3 (显示 SMAD3 蛋白) in injured arteries induces local smooth muscle cells CXCR4 expression and cell migration, and consequently intimal hyperplasia.
results characterize CXCR4 as an important pathway that modulates immune dysfunction and mortality following sepsis, which may hold promise as a target for future therapeutic intervention in septic patients
CXCL12 (显示 CXCL12 蛋白)/CXCR4 signaling negatively modulates the bipotential state of Hemogenic endothelial cells independently of the hematopoietic fate.
Efficient plasma cell differentiation and trafficking require Cxcr4 desensitization.
High CXCR4 expression is associated with Prostate Cancer.
Data show that FLT3 ligand (FLT3L (显示 FLT3LG 蛋白)) enhances thymopoiesis through increased survival and export of hematopoietic stem cell (Lin([minus])Sca1 (显示 ATXN1 蛋白)(+)c-Kit(+) [LSK (显示 LCK 蛋白)] cells via CXCR4 receptor regulation.
Activation of CXCL12 (显示 CXCL12 蛋白)/CXCR4 axis in vascular endothelial cells stimulates the angiogenesis.
OBW, as a novel inhibitor of CXCR4.
this study shows that cytoplasmic CXCR4 seems to correlate with biomarker changes associated with epithelial to mesenchymal transition in non-small-cell lung cancer
miR (显示 MLXIP 蛋白)-221-3p upregulation prevents IL-1beta (显示 IL1B 蛋白)-induced extracellular matrix (ECM (显示 MMRN1 蛋白)) degradation in chondrocytes. Protection of ECM (显示 MMRN1 蛋白) degradation by miR (显示 MLXIP 蛋白)-223-3p occurs via SDF1 (显示 CXCL12 蛋白)/CXCR4 signaling. miR (显示 MLXIP 蛋白)-221-3p is identified as a novel potential therapeutic target for osteoarthritis.
These results showed that targeting CXCR4 by CRISPR/Cas9 could inhibit proliferation, migration and invasion, reversed epithelial-mesenchymal transition , increased chemosensitivity and decrease the malignancy of HCC (显示 FAM126A 蛋白) in vitro and in vivo.
Results provide evidence that chemokine receptor CXCR4 plays a crucial role in mediating oxidative stress-induced (显示 SQSTM1 蛋白) podocyte injury, proteinuria, and renal fibrosis.
findings demonstrate that induction of ibrutinib resistance in WM cells can arise independent of BTK (显示 BTK 蛋白)(C481S) and CXCR4(WHIM-like) mutations and sustained pressure from ibrutinib appears to activate compensatory AKT (显示 AKT1 蛋白) signaling as well as reshuffling of Bcl-2 (显示 BCL2 蛋白) family proteins for maintenance of cell survival.
Tetramethylpyrazine-mediated regulation of CXCR4 in retinoblastoma is sensitive to cell density
Co-expression of Lgr5 (显示 LGR5 蛋白) and CXCR4 characterizes cancer stem-like cells of colorectal cancer.
We propose that DUX4 controls the cellular migration of mesenchymal stem cells through the CXCR4 receptor.
CXCR4 controls leukocyte mobilization after trauma.
The new method has shown to be capable of promoting CSCs proliferation and differentiation into cardiomyocytes through activating the SDF-1 (显示 CXCL12 蛋白)/CXCR4 axis, while inhibiting myocardial apoptosis , thereby enhancing myocardial regeneration.
reports transmural and perivascular expression patterns of chemokines CCL2 (显示 CCL2 蛋白) and CXCL2 (显示 CXCL2 蛋白) and of chemokine (显示 CCL1 蛋白) receptors CCR2 (显示 CCR2 蛋白), CCR5, and CXCR4 following coronary angioplasty
The current analysis failed in identifying a causal mutation on the CXCR4 gene underlying a previously reported quantitative trait loci for cattle trypanotolerance on bovine chromosome 2.
There is a potential link between follicular SDF1 (显示 CXCL12 蛋白)/CXCR4 activation and the regulation of ovulation-related genes in cows and horses.
The combination of low expression of CXCR4 and high expression of IL-10 (显示 IL10 蛋白) might be closely concerned with some bias for the production of PI calves.
The increased CXCR4 and CXCR7 (显示 CXCR7 蛋白) expression resulted in increased SDF-1 (显示 CXCL12 蛋白)-induced RF/6A cell migration and tube formation.
The CXCR7 (显示 CXCR7 蛋白)/CXCR4/CXCL12 (显示 CXCL12 蛋白) axis plays an important role in the formation of CNV, and may become a novel target for the treatment of choroidal neovascularization-associated diseases.
These findings suggest that FBLN5 (显示 FBLN5 蛋白) may interfere with choroidal neovascularization by downregulating VEGF (显示 VEGFA 蛋白), CXCR4, and TGFB1 (显示 TGFB1 蛋白) expression and inhibiting choroidl endothelial cell proliferation.
Virus recovered from CA28 plasma (SHIV(CA28NP)) used both CCR5 and CXCR4 for entry, but the virus recovered from lymph node (SHIV(CA28NL)) used CXCR4 almost exclusively
Arteries are formed by vein-derived endothelial tip cells, this process critically depends on chemokine receptor Cxcr4 function.
SDF1a (显示 CXCL12 蛋白) directly controls the migration of both leading and trailing edges of a tissue through the activation of two independent receptors, CXCR4b and CXCR7 (显示 CXCR7 蛋白).
Hoxb8a is induced by and cooperates with Wnt (显示 WNT2 蛋白) signaling to up-regulate cxcr4b, and acts through multiple mechanisms to repress cxcr7b expression.
Expression of Cxcr4 and Cxcl12 (显示 CXCL12 蛋白) in radial glial cells of the adult zebrafish brain supports important roles for the Cxcl12 (显示 CXCL12 蛋白)/Cxcr4 pair in brain development and functioning.
show that inactivation of the estrogen receptor ESR1 (显示 ESR1 蛋白) results in ectopic expression of cxcr4b throughout the primordium, whereas ESR1 (显示 ESR1 蛋白) overexpression results in a reciprocal reduction in the domain of cxcr4b expression.
Study suggest that the Cxcl12a-Cxcr4b ligand-receptor pair are involved in the migration of GnRH3 neurons in zebrafish, and are therefore crucial for the development of this system.
A CXCR4-like chemokine receptor is expressed by the migrating lateral line primordium cells. Both the formation and the innervation of this system depend on the SDF1 (显示 CXCL12 蛋白)-CXCR4 system.
Knocking down CXCR4 results in severe defects in primordial germ cell migration.
SDF-1 (显示 CXCL12 蛋白)/CXCR4 signaling is important for guiding retinal ganglion cell axons within the retina to the optic stalk to exit the retina.
chemokine (显示 CCL1 蛋白) signaling contributes to both the olfactory placode assembly and the olfactory sensory neurons axon pathfinding in zebrafish
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
C-X-C chemokine receptor type 4
, SDF-1 receptor
, Stromal cell-derived factor 1 receptor
, chemokine (C-X-C motif) receptor 4
, chemokine (C-X-C) receptor 4
, chemokine receptor 4
, leukocyte-derived seven transmembrane domain receptor
, leukocyte-expressed seven-transmembrane-domain
, pre-B-cell-derived chemokine receptor
, stromal cell-derived factor 1 receptor
, CXC chemokine receptor
, chemokine receptor (LCR1)
, CD184 antigen
, leukocyte-derived seven-transmembrane-domain receptor
, lipopolysaccharide-associated protein 3
, neuropeptide Y receptor Y3
, seven transmembrane helix receptor
, seven-transmembrane-segment receptor, spleen
, C-X-C chemokine receptor type 4-B
, SDF-1 receptor B
, SDF-1 receptor-B
, Stromal cell-derived factor 1 receptor-B
, stromal cell-derived factor 1 receptor B
, chemokine receptor CXCR4
, CXC chemokine receptor 4