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Human Aryl Hydrocarbon Receptor Protein expressed in Wheat germ - ABIN1344642
van den Bogaard, Bergboer, Vonk-Bergers, van Vlijmen-Willems, Hato, van der Valk, Schröder, Joosten, Zeeuwen, Schalkwijk: Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis. in The Journal of clinical investigation 2013
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Identified structural features of AHR1beta associated with low TCDD sensitivity. Substitution of the entire ligand binding domain with the corresponding sequence from mouse AHR(b-1) dramatically increased TCDD responsiveness in transactivation assays.
Transient AHR activation and cytochrome P450 1A (CYP1A) induction in livers occurred during ANIT-induced hepatobiliary impairment in medaka.
IRES (ribosome entry site)activity is increased in the PTX-resistant ovarian cancer cells in which AHR protein expression was also enhanced. These results strongly suggest an important role for AHR ribosome entry site (IRES)-dependent translation mechanism in cancer cell response to paclitaxel treatment
AhR activation by FICZ reduces FcepsilonRI (显示 FCER1G 蛋白) and upregulates IDO (显示 IDO1 蛋白) expression in Langerhans cells. This AhR-mediated anti-inflammatory feedback mechanism may dampen the allergen-induced inflammation in atopic dermatitis.
Report yeast estrogen screen for androgen- and estrogen-receptor (显示 ESR1 蛋白) mediated activities of 4-hydroxytestosterone, 4-hydroxyandrostenedione and their human metabolites.
Report AhR-dependent transcriptional activity during acute exposure of lung cells to distinct types of environmental pollutants.
The nuclear localization signal (NLS (显示 ALDH1A2 蛋白)) is closed in the absence of a ligand, the structure of AhR will be changed in the presence of a ligand, which leads to NLS (显示 ALDH1A2 蛋白) open, result in the nuclear translocation of AhR.
Study provides evidence that AhR plays a critical role in polycyclic aromatic hydrocarbon-mediated DNA damage.
in transcriptionally active heterodimer with ARNT (显示 ARNT 蛋白), which recognizes the dioxin response element (DRE (显示 SUFUH 蛋白)) in the promoter of downstream genes, right next to the DRE (显示 SUFUH 蛋白)-docking sites is the extensive dimerization surface that is more hydrophobic than other surface areas, indicating that the dimerization interface of the AHR transcription complex is largely dictated by hydrophobic contacts
AHR signaling is essential for activin A (显示 INHBA 蛋白) induced regulatory T cells that restrain asthmatic responses.
Aryl hydrocarbon receptor activation induced by FICZ and Glyteer increased the expression of OVOL1 (显示 OVOL1 蛋白) and Filaggrin (显示 FLG 蛋白) in a dose- and time-dependent manner in normal human epidermal keratinocytes.
Study shows the Q-rich/PST (显示 SULT1A1 蛋白) domain of the aryl hydrocarbon receptor regulates both ligand-induced nuclear transport and nucleocytoplasmic shuttling.
homology models of the porcine AhR-ligand binding domain (LBD) and the porcine aryl hydrocarbon receptor nuclear translocator (显示 ARNT 蛋白)-ligand binding domain (ARNT (显示 ARNT 蛋白)-LBD) were created.
steroid hormones, AhR and estrogen receptor beta (显示 ESR2 蛋白) are affected by TCDD and genistein in granulosa cells of medium porcine follicles
AHR mRNA expression in follicular, theca, and granulosa cells suggest the involvement of AHR in the modulation of reproductive processes in the porcine ovary.
Deletion of the Ahr gene in cardiomyocytes protects males from heart dysfunction due to NKX2.5 (显示 NKX2-5 蛋白) haploinsufficiency.
Identify Cxcl5 (显示 CXCL5 蛋白) as a novel target of AHR-mediated gene expression in primary mouse keratinocytes.
this study shows that tryptophan metabolite activation of the aryl hydrocarbon receptor regulates IL-10 (显示 IL10 蛋白) receptor expression on intestinal epithelia
Ambient particulate matter enhances dendritic cell activation that primes naive T cell differentiation towards a Th17-like phenotype in an AhR-dependent manner.
AHR role in the acute lethal pulmonary inflammation
These findings highlight the physiologic importance of cell-type specific balancing of AhR/AhRR (显示 AHRR 蛋白) expression in response to microbial, nutritional and other environmental stimuli. Specifically, AhRR (显示 AHRR 蛋白) contributes to the maintenance of colonic intraepithelial lymphocytes and prevents excessive IL-1beta (显示 IL1B 蛋白) production and Th17/Tc17 differentiation. In contrast, the AhRR (显示 AHRR 蛋白) enhances IFN-gamma (显示 IFNG 蛋白)-production by effector T cells in the in...
these data support that RelB (显示 RELB 蛋白) suppresses cigarette smoke-induced apoptosis, potentially by increasing the AhR
Results elucidate the dimerization process of AhR with ARNT (显示 ARNT 蛋白) and propose the structure of the N-terminal region of the AhR:ARNT dimer including the bHLH, PAS (显示 PASK 蛋白)-A and PAS (显示 PASK 蛋白)-B domains.
the AhR pathway is much more that a xenobiotic metabolism-inducing pathway, and the regulation by AhR of Notch (显示 NOTCH1 蛋白) signaling in the testis offers some insight into the mechanism of infertility in men.
UV and environmental stimulation of melanoblast-to-melanocyte maturation are enhanced via the AHR pathway.
This gene encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Its ligands included a variety of aromatic hydrocarbons.
aryl hydrocarbon receptor
, aryl hydrocarbon receptor 1
, aryl hydrocarbon receptor-like
, ah receptor
, aromatic hydrocarbon receptor
, class E basic helix-loop-helix protein 76
, Ah receptor
, dioxin receptor