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Human Aryl Hydrocarbon Receptor Protein expressed in Wheat germ - ABIN1344642
van den Bogaard, Bergboer, Vonk-Bergers, van Vlijmen-Willems, Hato, van der Valk, Schröder, Joosten, Zeeuwen, Schalkwijk: Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis. in The Journal of clinical investigation 2013
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Identified structural features of AHR1beta associated with low TCDD sensitivity. Substitution of the entire ligand binding domain with the corresponding sequence from mouse AHR(b-1) dramatically increased TCDD responsiveness in transactivation assays.
Transient AHR activation and cytochrome P450 1A (CYP1A) induction in livers occurred during ANIT-induced hepatobiliary impairment in medaka.
In human keratinocytes, authors found that perillaldehyde (1) inhibited BaP (显示 PHB2 蛋白)-induced AHR activation and ROS (显示 ROS1 蛋白) production, (2) inhibited BaP (显示 PHB2 蛋白)/AHR-mediated release of the CCL2 (显示 CCL2 蛋白) chemokine (显示 CCL1 蛋白), and (3) activated the NRF2 (显示 GABPA 蛋白)/HO1 (显示 HMOX1 蛋白) antioxidant pathway.
Infants born to women with specific AHR and XRCC1 (显示 XRCC1 蛋白) genotypes may have higher genetic risks for birth weight reduction
ITE suppresses growth of human pulmonary artery endothelial cells independent of AhR
High AHR expression is associated with nerve sheath tumorigenesis.
IRES (ribosome entry site)activity is increased in the PTX-resistant ovarian cancer cells in which AHR protein expression was also enhanced. These results strongly suggest an important role for AHR ribosome entry site (IRES)-dependent translation mechanism in cancer cell response to paclitaxel treatment
AhR activation by FICZ reduces FcepsilonRI (显示 FCER1G 蛋白) and upregulates IDO (显示 IDO1 蛋白) expression in Langerhans cells. This AhR-mediated anti-inflammatory feedback mechanism may dampen the allergen-induced inflammation in atopic dermatitis.
Report yeast estrogen screen for androgen- and estrogen-receptor (显示 ESR1 蛋白) mediated activities of 4-hydroxytestosterone, 4-hydroxyandrostenedione and their human metabolites.
Report AhR-dependent transcriptional activity during acute exposure of lung cells to distinct types of environmental pollutants.
The nuclear localization signal (NLS (显示 ALDH1A2 蛋白)) is closed in the absence of a ligand, the structure of AhR will be changed in the presence of a ligand, which leads to NLS (显示 ALDH1A2 蛋白) open, result in the nuclear translocation of AhR.
Study provides evidence that AhR plays a critical role in polycyclic aromatic hydrocarbon-mediated DNA damage.
homology models of the porcine AhR-ligand binding domain (LBD) and the porcine aryl hydrocarbon receptor nuclear translocator (显示 ARNT 蛋白)-ligand binding domain (ARNT (显示 ARNT 蛋白)-LBD) were created.
steroid hormones, AhR and estrogen receptor beta (显示 ESR2 蛋白) are affected by TCDD and genistein in granulosa cells of medium porcine follicles
AHR mRNA expression in follicular, theca, and granulosa cells suggest the involvement of AHR in the modulation of reproductive processes in the porcine ovary.
Shared epitope-aryl hydrocarbon receptor crosstalk underlies the mechanism of gene-environment interaction in autoimmune arthritis.
airway inflammatory cells and cytokines present in BALF and TRIF (显示 RNF138 蛋白) in lung tissue play a role in inducing AHR and airway inflammation upon RSV and bacteria coinfection
Ectopic activation of AHR during early differentiation disrupts the differentiation program via the chromatin remodeling complex NuRD.
AhR activation ameliorated epithelial barrier dysfunction following intestinal ischemia/reperfusion and hypoxia through upregulation of Notch1 (显示 NOTCH1 蛋白) signaling.
Low AHR expression is associated with provokes locomotor defects and alteration of myelin structure.
Data indicate aryl hydrocarbon receptor (AhR) and small heterodimer partner (SHP (显示 NR0B2 蛋白)) as new physiological regulators of phosphatidylcholines (PC) and S-adenosylmethionine (SAM (显示 TTN 蛋白)) levels.
These results suggested that AhR deficiency resulted in increased susceptibility to colitis, whereas activation of AhR by FICZ could ameliorate DSSinduced colitis via the MK2 (显示 KCNA2 蛋白)/pMK2/TTP (显示 ZFP36 蛋白) pathway.
These results validate the role of the AhR pathway in regulating choroidal neovascular pathogenesis, identify mechanisms of AhR-based therapies in the eye, and argue in favor of developing AhR as a drug target for the treatment of neovascular AMD (显示 AMD1 蛋白).
Deletion of the Ahr gene in cardiomyocytes protects males from heart dysfunction due to NKX2.5 (显示 NKX2-5 蛋白) haploinsufficiency.
Identify Cxcl5 (显示 CXCL5 蛋白) as a novel target of AHR-mediated gene expression in primary mouse keratinocytes.
This gene encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Its ligands included a variety of aromatic hydrocarbons.
aryl hydrocarbon receptor
, aryl hydrocarbon receptor 1
, aryl hydrocarbon receptor-like
, ah receptor
, aromatic hydrocarbon receptor
, class E basic helix-loop-helix protein 76
, Ah receptor
, dioxin receptor