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Human Aryl Hydrocarbon Receptor Protein expressed in Wheat germ - ABIN1344642
van den Bogaard, Bergboer, Vonk-Bergers, van Vlijmen-Willems, Hato, van der Valk, Schröder, Joosten, Zeeuwen, Schalkwijk: Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis. in The Journal of clinical investigation 2013
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Identified structural features of AHR1beta associated with low TCDD sensitivity. Substitution of the entire ligand binding domain with the corresponding sequence from mouse AHR(b-1) dramatically increased TCDD responsiveness in transactivation assays.
Transient AHR activation and cytochrome P450 1A (CYP1A) induction in livers occurred during ANIT-induced hepatobiliary impairment in medaka.
These results suggest that D-Kyn increases lung cancer cells to metastasize by activating Ahr.
The role of IDO1 (显示 IDO1 蛋白)-IDO2 (显示 IDO2 蛋白)-AHR pathway in the TLR4 (显示 TLR4 蛋白)-induced tolerogenic phenotype in human dendritic cells has been reported.
The association between AHR Arg55Lys polymorphism and male infertility risk was not confirmed (Meta-Analysis)
A meta-analysis of five sets of data evaluated the association of aryl hydrocarbon receptor 1661G>A with male infertility.
IDO decreased glycolysis and glutaminolysis by activating GCN2K, resulting in activation of AMPactivated protein kinase.
AHR inhibition or knockdown/knockout consistently reduced human ER-/PR-/Her2 (显示 ERBB2 蛋白)- and inflammatory breast cancer cell invasion, migration, and metastasis. This was associated with a decrease in invasion-associated genes (e.g., Fibronectin (显示 FN1 蛋白), VCAM1 (显示 VCAM1 蛋白), Thrombospondin, MMP1 (显示 MMP1 蛋白)) and an increase in CDH1/E-cadherin (显示 CDH1 蛋白), previously associated with decreased tumor aggression.
This study demonstrated that the regulation of AHR expression by miR124 is critical to the development of inflammatory response in chronic rhinosinusitis with nasal polyps.
In human keratinocytes, authors found that perillaldehyde (1) inhibited BaP (显示 PHB2 蛋白)-induced AHR activation and ROS (显示 ROS1 蛋白) production, (2) inhibited BaP (显示 PHB2 蛋白)/AHR-mediated release of the CCL2 (显示 CCL2 蛋白) chemokine (显示 CCL1 蛋白), and (3) activated the NRF2 (显示 GABPA 蛋白)/HO1 (显示 HMOX1 蛋白) antioxidant pathway.
Infants born to women with specific AHR and XRCC1 (显示 XRCC1 蛋白) genotypes may have higher genetic risks for birth weight reduction
ITE suppresses growth of human pulmonary artery endothelial cells independent of AhR
homology models of the porcine AhR-ligand binding domain (LBD) and the porcine aryl hydrocarbon receptor nuclear translocator (显示 ARNT 蛋白)-ligand binding domain (ARNT (显示 ARNT 蛋白)-LBD) were created.
steroid hormones, AhR and estrogen receptor beta (显示 ESR2 蛋白) are affected by TCDD and genistein in granulosa cells of medium porcine follicles
AHR mRNA expression in follicular, theca, and granulosa cells suggest the involvement of AHR in the modulation of reproductive processes in the porcine ovary.
Distribution of parent PCB (显示 PC 蛋白) congeners also varied by genotype with strikingly high levels of PCB (显示 PC 蛋白) 77 in poor-affinity Ahr (d) Cyp1a2 (显示 CYP1A1 蛋白)(-/-) while Ahr (b) Cyp1a2 (显示 CYP1A1 蛋白)(+/+) mice effectively sequestered coplanar PCBs in the liver.
these data support a prominent role for the AhR in regulating lung miRNA expression.
In air-exposed airway epithelia, induction of factors required for multiciliogenesis, including cyclin O (Ccno (显示 CCNO 蛋白)) and Multicilin (显示 MCIN 蛋白) (Mcidas), is AhR dependent, and air exposure induces AhR binding to the Ccno (显示 CCNO 蛋白) promoter. Submersion and hypoxic conditions impede AhR-dependent Ccno (显示 CCNO 蛋白) induction.
Shared epitope-aryl hydrocarbon receptor crosstalk underlies the mechanism of gene-environment interaction in autoimmune arthritis.
airway inflammatory cells and cytokines present in BALF and TRIF (显示 RNF138 蛋白) in lung tissue play a role in inducing AHR and airway inflammation upon RSV and bacteria coinfection
Ectopic activation of AHR during early differentiation disrupts the differentiation program via the chromatin remodeling complex NuRD.
AhR activation ameliorated epithelial barrier dysfunction following intestinal ischemia/reperfusion and hypoxia through upregulation of Notch1 (显示 NOTCH1 蛋白) signaling.
Low AHR expression is associated with provokes locomotor defects and alteration of myelin structure.
Data indicate aryl hydrocarbon receptor (AhR) and small heterodimer partner (SHP (显示 NR0B2 蛋白)) as new physiological regulators of phosphatidylcholines (PC) and S-adenosylmethionine (SAM (显示 TTN 蛋白)) levels.
These results suggested that AhR deficiency resulted in increased susceptibility to colitis, whereas activation of AhR by FICZ could ameliorate DSSinduced colitis via the MK2 (显示 KCNA2 蛋白)/pMK2/TTP (显示 ZFP36 蛋白) pathway.
This gene encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Its ligands included a variety of aromatic hydrocarbons.
aryl hydrocarbon receptor
, aryl hydrocarbon receptor 1
, aryl hydrocarbon receptor-like
, ah receptor
, aromatic hydrocarbon receptor
, class E basic helix-loop-helix protein 76
, Ah receptor
, dioxin receptor