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Human Monoclonal APOE Primary Antibody for CyTOF, ELISA - ABIN258785
Wahrle, Jiang, Parsadanian, Hartman, Bales, Paul, Holtzman: Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease. in The Journal of biological chemistry 2005
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Human Polyclonal APOE Primary Antibody for ELISA, WB - ABIN543949
Christensen, Batterham, Mackinnon, Jorm, Mack, Mather, Anstey, Sachdev, Easteal: The association of APOE genotype and cognitive decline in interaction with risk factors in a 65-69 year old community sample. in BMC geriatrics 2008
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Human Polyclonal APOE Primary Antibody for IHC, WB - ABIN2774066
Ho, Niti, Yap, Kua, Ng: Metabolic syndrome and cognitive decline in chinese older adults: results from the singapore longitudinal ageing studies. in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2008
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Human Polyclonal APOE Primary Antibody for IHC (p), ELISA - ABIN1997537
Li, Jiang, Qu, Yao, Cai, Chen, Peng: Hepatocyte nuclear factor 4? and downstream secreted phospholipase A2 GXIIB regulate production of infectious hepatitis C virus. in Journal of virology 2013
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Human Monoclonal APOE Primary Antibody for FACS, IHC - ABIN968962
Karpouzis, Caridha, Tripsianis, Michailidis, Martinis, Veletza: Apolipoprotein E gene polymorphism in psoriasis. in Archives of dermatological research 2009
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Monoclonal APOE Primary Antibody for IHC (fro), ELISA - ABIN534094
Krul, Tikkanen, Schonfeld: Heterogeneity of apolipoprotein E epitope expression on human lipoproteins: importance for apolipoprotein E function. in Journal of lipid research 1989
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Human Polyclonal APOE Primary Antibody for IHC - ABIN6713286
Park, Kim, Bae, Hong, Lee, Leem, Choi, Shin: Protective effect of the phosphodiesterase III inhibitor cilostazol on amyloid β-induced cognitive deficits associated with decreased amyloid β accumulation. in Biochemical and biophysical research communications 2011
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Human Polyclonal APOE Primary Antibody for IF (p), IHC (p) - ABIN1386767
Liu, Gao, Hao, Lou, Zhang, Li, Wu, Xiao, Yang, Li, Qiu, Wang: Secretomes are a potential source of molecular targets for cancer therapies and indicate that APOE is a candidate biomarker for lung adenocarcinoma metastasis. in Molecular biology reports 2014
Mouse (Murine) Polyclonal APOE Primary Antibody for IF (p), IHC (p) - ABIN725750
Chiu, Chan, Yang, Liu, Chiang: Supplementation of Chitosan Alleviates High-Fat Diet-Enhanced Lipogenesis in Rats via Adenosine Monophosphate (AMP)-Activated Protein Kinase Activation and Inhibition of Lipogenesis-Associated Genes. in Journal of agricultural and food chemistry 2015
Human Monoclonal APOE Primary Antibody for FACS, IHC - ABIN965577
Zintzaras, Kitsios, Triposkiadis, Lau, Raman: APOE gene polymorphisms and response to statin therapy. in The pharmacogenomics journal 2009
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current results reveal long-term effects in mice nine months after postnatal exposure to CPF, which are modulated by sex and apoE4 genotype
Rosuvastatin protected SR-B1(-/-)/apoE(-/-) mice against atherosclerosis and platelet accumulation in coronary arteries and attenuated myocardial fibrosis and cardiomegaly, despite increased plasma total cholesterol.
CoQ10 also inhibited inflammation (IL-6 and TNF-a) gene expression in ApoE(-/-) mice. These results indicate that CoQ10 is a potential therapeutic target for cardiac damage caused by hyperlipidemia
myeloid-produced apoE is a key physiological modulator of dendritic cell antigen presentation function
APOE epsilon2 is associated with increased tau pathology in primary tauopathy
Intratracheal instillation of particles (0.5 or 5 mg/kg) once a week for 5 weeks in ApoE-/- mice was associated with an accelerated progression of atherosclerosis in aorta and telomere shortening in the lung and spleen, whereas there was no effect on inflammation in the lungs
The ApoE Deletion Increases Both White Matter and Neuronal Injury After Subarachnoid Hemorrhage in Mice.
Using ex vivo and in vivo microscopy, we analyzed the interactive behavior of quantum dots with different surface functionalizations in atherosclerotic lesions of ApoE-deficient mice.
Aged ApoE-Knock Out mice exhibit severe osteoporosis compared to Wild Type mice. ApoE promotes osteoblastogenesis via ERK1/2 pathway.
These novel findings demonstrate that RAGE deficiency protects against aortic valve calcification in high cholesterol diet-fed ApoE(-/-) mice via inhibition of endoplasmic reticulum stress.
FGF21 alleviated atherosclerosis by ameliorating Fas-mediated apoptosis in apoE-/- mice.
The mice were crossed onto the athero-prone apoE(-/-) background to obtain Plpp3(f/f)apoE(-/-)Alb-Cre(+) and Plpp3(f/f)apoE(-/-)Alb-Cre(-) offspring, the latter of which were used as controls. The mice were fed chow or a Western diet for 32 or 12 weeks, respectively
results support that there are different vulnerabilities to postnatal CPF exposure according to the APOE polymorphism, which in turn affects the cholinergic system and defenses to oxidative stress
forskolin/rolipram incorporated into liposomes, designed to target inflamed endothelium, shows reduced atherosclerosis and CC formation in ApoE -/- mice
exposure to repeated social defeat promotes atherosclerosis by augmenting NETs formation within the plaque in socially defeated apoE(-/-) mice.
In vivo, the NHE6 knockout (NHE6(KO)) mouse model showed elevated Abeta in the brain, consistent with a causal effect. Increased nuclear translocation of histone deacetylase 4 (HDAC4) in ApoE4 astrocytes, compared with the nonpathogenic ApoE3 allele, suggested a mechanistic basis for transcriptional down-regulation of NHE6.
Platelet activation in ApoE and LDLR-deficient mice was not further increased by strenuous exercise, but was instead attenuated.
the ApoE KO and DKO mice cannot serve as mouse models for studying AD or pathological brain changes compatible with atherosclerosis.
High-fat and high-cholesterol diet induced atherosclerosis faster and more severe than normal diet in ApoE(-/-) mice35
Exenatide enhances adiponectin production and the attenuates atherosclerotic plaque oxidative stress, inflammation, and proteolysis in ApoE(-/-) mice under chronic stress fed high fat diet.
Data highlight a pathogenic role of apoE4 that could be linked to the capacity of the protein to form oligomeric species especially in the presence of Abeta42 and to induce cytotoxicity. Carboxyl-terminal residues L279, K282 or Q284 appear to be involved in the conformation of apoE4 that may underlie the protein's functional properties related to neurotoxicity.
rs4420638 at the APOE locus was associated with an increased risk of type 2 Diabetes and a decreased risk of Coronary Artery Disease.
The results show that in Thai individuals, the presence of ApoE4 allele is accompanied by a multifarious decline in neurocognitive functions and behavioral features and that ApoE3 may convey protection against neuropsychiatric symptoms and a decline in social skills.
A -219T/G heterozygosity increased risk for Alzheimer's disease in APOE epsilon4 carriers, but not in APOE epsilon4 non-carriers.
Systematic review and meta-analysis found no evidence that APOE epsilon4 carriership or zygosity is associated with the presence of depression, anxiety, apathy, agitation, irritability or sleep disturbances in cognitively impaired subjects.
Young healthy adults carrying APOE epsilon4 and APP/presenilin-1/2 displayed different hippocampus functional connectivity patterns
The methylation of APOE was important for the risk of Coronary Heart Disease in men.
incidence of amnestic mild cognitive impairment (aMCI) in Tujia region of Enshi may be related to the rs744373 polymorphic site of BIN1 gene, ApoEepsilon2 is the protective factor and ApoEepsilon4 is the risk factor for aMCI in Tujia region of Enshi
The lower level of HDL-C and ApoA1 and higher ratios of total cholesterol:HDL-C, LDL-C:HDL-C, and ApoB:ApoA1 are risk factors for MI in young patients. No significant pattern of ApoE polymorphisms was observed.
APOE4 is not associated with the recovery of sleep disturbance after mild traumatic brain injury
No significant association between ApoE genotype status and the presence of white matter hyperintensities after high altitude exposure.
Cognitively normal, elderly E4/E4 show an atypical pattern of both brain hypometabolism and amyloid deposition compared with that known to occur in Late-Onset Alzheimer's Disease. Metabolism is dissociated in localization from amyloid deposition. The region of greatest amyloid deposition localizes to the putamen.
the potential relationship of APOE rs7412 and rs429358 with pregnancy loss (PL) in Bosnian women, was investigated.
ApoE epsilon-4 carriers with cognitive impairment increased latency evoked potentials P300 and N200.
Young Alzheimer's (<65y) APOE4 noncarriers had the most severe frontal and perisylvian atrophy, while in old (>/=75y) APOE4 carriers had the most severe medial temporal atrophy. In <75y APOE4 noncarriers and heterozygotes showed worse performance in language, visuospatial, and frontal function compared to homozygotes, while, in old >/=75y APOE4 homozygotes showed worse performance in memory compared to noncarriers.
the effects of apoE and HLA DRB1*13 on brain function by examining changes in neural network properties with age in healthy adults, is reported.
APOE varepsilon4 allele carriers that predominantly use non-spatial strategies have decreased fMRI activity in the hippocampus and increased atrophy in the hippocampus, entorhinal cortex, and fimbria compared to APOE varepsilon4 allele carriers who use spatial strategies. In contrast, APOE varepsilon4 allele carriers who use spatial strategies have grey matter levels comparable to non-APOE varepsilon4 allele carriers.
This study shows by Atomic Force Microscopy that attachment of ApoE4/ABETA complexes to basement membrane laminin is significantly weaker than ApoE3/ABETA complexes.
GMF and ApoE4 were strongly expressed and co-associated in amyloid plaques (APs) and in the reactive astrocytes surrounding APs in Alzheimer's disease.
Both groups of older adults showed enhanced recognition memory for narrative information following self-referential processing relative to semantic elaboration, and the magnitude of this memory effect was not affected by epsilon4 status. However, older adult epsilon4 carriers did not show an emotional enhancement effect, whereas older adult epsilon4 noncarriers did.
we report the efficient creation of an APOE knockout rabbit by using zinc finger nucleases. The knockout rabbits had drastically elevated cholesterol and moderately increased triglyceride levels, mimicking symptoms in human heart disease.
These differentially expressed proteins associated with key mechanisms involved in atherosclerosis and signaling mechanisms related with vitamin E.
The molar ratio ApoE/ApoA-I is negatively correlated with the enzyme activity, and positively correlated with increases in the intima-media thickness of common carotid wall and cardiac dysfunction signs.
ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL paraoxonase activity
The identification of disulphide-linked apoE dimers in cortical and hippocampal tissues represents a distinct structural difference between the apoE3 and apoE4 isoforms that may have functional consequences.
These data suggest that the -155T>A mutation in the promoter region of the porcine APOE gene is an important functional variant
Nonesterified fatty acids significantly inhibit the expression of ApoB100, ApoE, MTP, and LDLR, thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.
Bovine apoE contents in triglyceride-rich lipoproteins are modulated by nutritional treatment and closely associated with triglyceride-rich lipoprotein metabolism
apoE-containing particles, which increased during the lactating stage, were not associated with HDL particles, and lipid-free forms were included in cow plasma
after calving the apolipoprotein B(100) mRNA synthesis was lower, whereas microsomal triglyceride transfer protein (MTP) and apolipoprotein E messenger RNA abundance were higher in the liver
The study found no coding variation within and between chimpanzee populations, suggesting that the maintenance of functionally diverse APOE polymorphisms is a unique feature of human evolution.
ApoE evolution and very likely the evolution of other apolipoproteins are influenced by feeding environment and diet of humans, chimpanzees and various other species.
In the hippocampus APOE protein levels were higher in good spatial performers than poor spatial performers animals
Allele frequencies of the ApoE gene found show that allele epsilon3 has one of the highest frequencies and epsilon4 allele one of the lowest compared to other population groups in the world
There was significantly more apoE immunoreactivity in the prefrontal cortex and hippocampus of aged animals compared to adult or middle-aged animals.
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
, apolipoprotein E3