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抗Mouse (Murine) APOE 抗体:
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抗Rat (Rattus) APOE 抗体:
Human Monoclonal APOE Primary Antibody for CyTOF, ELISA - ABIN258785
Wahrle, Jiang, Parsadanian, Hartman, Bales, Paul, Holtzman: Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease. in The Journal of biological chemistry 2005
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Human Polyclonal APOE Primary Antibody for IHC, WB - ABIN2774066
Ho, Niti, Yap, Kua, Ng: Metabolic syndrome and cognitive decline in chinese older adults: results from the singapore longitudinal ageing studies. in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2008
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Human Polyclonal APOE Primary Antibody for IHC (p), ELISA - ABIN1997537
Li, Jiang, Qu, Yao, Cai, Chen, Peng: Hepatocyte nuclear factor 4? and downstream secreted phospholipase A2 GXIIB regulate production of infectious hepatitis C virus. in Journal of virology 2013
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Human Monoclonal APOE Primary Antibody for FACS, IHC - ABIN968962
Karpouzis, Caridha, Tripsianis, Michailidis, Martinis, Veletza: Apolipoprotein E gene polymorphism in psoriasis. in Archives of dermatological research 2009
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Human Polyclonal APOE Primary Antibody for IHC (p), WB - ABIN391849
Benga, Krieger, Dimitrova, Zeisel, Parnot, Lupberger, Hildt, Luo, McLauchlan, Baumert, Schuster: Apolipoprotein E interacts with hepatitis C virus nonstructural protein 5A and determines assembly of infectious particles. in Hepatology (Baltimore, Md.) 2009
Mouse (Murine) Polyclonal APOE Primary Antibody for ID, RID - ABIN151509
Terwel, Steffensen, Verghese, Kummer, Gustafsson, Holtzman, Heneka: Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2011
Human Polyclonal APOE Primary Antibody for IHC (p), IP - ABIN152926
Atkinson, Blumenstein, Black, Wu, Kasabov, Taylor, Cooper, North: An altered pattern of circulating apolipoprotein E3 isoforms is implicated in preeclampsia. in Journal of lipid research 2008
Human Polyclonal APOE Primary Antibody for IHC (p), IHC - ABIN250408
Dodart, Marr, Koistinaho, Gregersen, Malkani, Verma, Paul: Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease. in Proceedings of the National Academy of Sciences of the United States of America 2005
Mouse (Murine) Polyclonal APOE Primary Antibody for IF (p), IHC (p) - ABIN725750
Chiu, Chan, Yang, Liu, Chiang: Supplementation of Chitosan Alleviates High-Fat Diet-Enhanced Lipogenesis in Rats via Adenosine Monophosphate (AMP)-Activated Protein Kinase Activation and Inhibition of Lipogenesis-Associated Genes. in Journal of agricultural and food chemistry 2015
Human Polyclonal APOE Primary Antibody for IF (p), IHC (p) - ABIN1386767
Liu, Gao, Hao, Lou, Zhang, Li, Wu, Xiao, Yang, Li, Qiu, Wang: Secretomes are a potential source of molecular targets for cancer therapies and indicate that APOE is a candidate biomarker for lung adenocarcinoma metastasis. in Molecular biology reports 2014
Platelet activation in ApoE and LDLR (显示 LDLR 抗体)-deficient mice was not further increased by strenuous exercise, but was instead attenuated.
the ApoE KO and DKO mice cannot serve as mouse models for studying AD or pathological brain changes compatible with atherosclerosis.
High-fat and high-cholesterol diet induced atherosclerosis faster and more severe than normal diet in ApoE(-/-) mice35
Exenatide enhances adiponectin production and the attenuates atherosclerotic plaque oxidative stress, inflammation, and proteolysis in ApoE(-/-) mice under chronic stress fed high fat diet.
Enhanced mitochondrial oxidative stress under hyperlipidemic conditions in aging induces plaque instability, in part by increasing smooth muscle cell apoptosis, necrotic core expansion, and matrix degradation in Sod2 (显示 SOD2 抗体)/ApoE knockout mice.
Danshensu Bingpian Zhi has antiatherosclerotic effects that involve the inhibition of inflammation, macrophage migration, leukocyte adhesion, and foam cell formation in ApoE-deficient mice.
Stimulation of nAChRalpha7 with GTS-21 reduced atherosclerosis, which was associated with dampened splenic myelopoiesis in ApoE knockout mice.
Subcutaneous injection of dendritic cells aggravates atherosclerosis in ApoE-knockout mice by activation of TLR4 (显示 TLR4 抗体).
ApoE is essential to the development of cerebral malaria. The protection from ECM (显示 MMRN1 抗体) provided by the deletion of ApoE correlated with decreased sequestration of parasitized RBCs and T cells within the brain and was independent from the involvement of ApoE receptors and from the altered lipid metabolism present in the knock-out mice.
SP-D (显示 SFTPD 抗体) deficiency reduces atherosclerosis in ApoE-knockout mice by decreasing the accumulation and proliferation of macrophages and by reducing IL-6 (显示 IL6 抗体) levels systemically.
Findings revealed that APOE epsilon4 allele has a detrimental effect on parietal and frontal white matter in cognitively normal elderly; and demonstrate that information processing speed deficits can be explained by parietal white matter hyperintensities volume, age and interaction between parietal white matter hyperintensities volume and age.
The study demonstrated that the APOE epsilon3/epsilon3 and epsilon3/epsilon4 genotypes played a protective role against cerebral infarction in Chinese men, but not women.
corroborating evidence that supports the fact that the presence of the APOE e4 polymorphism confers greater susceptibility to combat-related post-traumatic stress disorder (meta-analysis)>
Carriers of the 4 allele of the APOE genotype had significantly lower LDL particle size and LDL I proportion compared to 33 homozygotes ( P < .05 for both comparisons). Insulin (显示 INS 抗体) resistance increased from patients with no OSA to those with mild-moderate and to those with severe OSA ( P < .001). In multivariate analysis, LDL size was independently predicted by APOE genotype.
In het mice, RIF had no effect on plasma lipids composition, CYP27A1 (显示 CYP27A1 抗体) activity, and atherosclerotic plaque development, despite a reduction in cholesterol absorption. In conclusion, the antiatherogenic effect of Cyp3a11 induction by RIF was also dependent on Cyp27a1 (显示 CYP27A1 抗体) expression.
Hypertension and the ApoEepsilon4/epsilon4 genotype may be associated with the occurrence of MCA (显示 RSPH1 抗体) stenosis in the ischemic stroke Chinese patients.
APOE polymorphism has an influence on the risk of aneurysmal subarachnoid hemorrhage.
Evidence for an interaction between APOE SNP rs1064725 and dietary fat intake on fasting total plasma cholesterol concentrations.
APOE-epsilon4 carriers had elevated carotid intima media thickness independent of demographics and vascular risk factors. Diabetes was an effect modifier of the relationship between APOE-epsilon4 and cIMT.
APOE is a risk gene for ischemic stroke (IS), but not independent, especially for large artery atherosclerosis IS.
we report the efficient creation of an APOE knockout rabbit by using zinc finger nucleases. The knockout rabbits had drastically elevated cholesterol and moderately increased triglyceride levels, mimicking symptoms in human heart disease.
The molar ratio ApoE/ApoA-I (显示 APOA1 抗体) is negatively correlated with the enzyme activity, and positively correlated with increases in the intima-media thickness of common carotid wall and cardiac dysfunction signs.
ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL (显示 HSD11B1 抗体) paraoxonase activity
The identification of disulphide-linked apoE dimers in cortical and hippocampal tissues represents a distinct structural difference between the apoE3 and apoE4 isoforms that may have functional consequences.
These data suggest that the -155T>A mutation in the promoter region of the porcine APOE gene is an important functional variant
Nonesterified fatty acids significantly inhibit the expression of ApoB100 (显示 APOB 抗体), ApoE, MTP (显示 MTTP 抗体), and LDLR (显示 LDLR 抗体), thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.
Bovine apoE contents in triglyceride-rich lipoproteins are modulated by nutritional treatment and closely associated with triglyceride-rich lipoprotein metabolism
apoE-containing particles, which increased during the lactating stage, were not associated with HDL (显示 HSD11B1 抗体) particles, and lipid-free forms were included in cow plasma
after calving the apolipoprotein B(100 (显示 APOB 抗体)) mRNA synthesis was lower, whereas microsomal triglyceride transfer protein (MTP (显示 MTTP 抗体)) and apolipoprotein E messenger RNA abundance were higher in the liver
The study found no coding variation within and between chimpanzee populations, suggesting that the maintenance of functionally diverse APOE polymorphisms is a unique feature of human evolution.
ApoE evolution and very likely the evolution of other apolipoproteins are influenced by feeding environment and diet of humans, chimpanzees and various other species.
In the hippocampus APOE protein levels were higher in good spatial performers than poor spatial performers animals
Allele frequencies of the ApoE gene found show that allele epsilon3 has one of the highest frequencies and epsilon4 allele one of the lowest compared to other population groups in the world
There was significantly more apoE immunoreactivity in the prefrontal cortex and hippocampus of aged animals compared to adult or middle-aged animals.
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
, apolipoprotein E3