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抗Mouse (Murine) APOE 抗体:
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抗Rat (Rattus) APOE 抗体:
Human Monoclonal APOE Primary Antibody for CyTOF, ELISA - ABIN258785
Wahrle, Jiang, Parsadanian, Hartman, Bales, Paul, Holtzman: Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease. in The Journal of biological chemistry 2005
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Human Polyclonal APOE Primary Antibody for IHC, WB - ABIN2774066
Ho, Niti, Yap, Kua, Ng: Metabolic syndrome and cognitive decline in chinese older adults: results from the singapore longitudinal ageing studies. in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2008
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Human Polyclonal APOE Primary Antibody for IHC (p), ELISA - ABIN1997537
Li, Jiang, Qu, Yao, Cai, Chen, Peng: Hepatocyte nuclear factor 4? and downstream secreted phospholipase A2 GXIIB regulate production of infectious hepatitis C virus. in Journal of virology 2013
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Human Monoclonal APOE Primary Antibody for FACS, IHC - ABIN968962
Karpouzis, Caridha, Tripsianis, Michailidis, Martinis, Veletza: Apolipoprotein E gene polymorphism in psoriasis. in Archives of dermatological research 2009
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Mouse (Murine) Polyclonal APOE Primary Antibody for IF (p), IHC (p) - ABIN725750
Chiu, Chan, Yang, Liu, Chiang: Supplementation of Chitosan Alleviates High-Fat Diet-Enhanced Lipogenesis in Rats via Adenosine Monophosphate (AMP)-Activated Protein Kinase Activation and Inhibition of Lipogenesis-Associated Genes. in Journal of agricultural and food chemistry 2015
Human Polyclonal APOE Primary Antibody for IF (p), IHC (p) - ABIN1386767
Liu, Gao, Hao, Lou, Zhang, Li, Wu, Xiao, Yang, Li, Qiu, Wang: Secretomes are a potential source of molecular targets for cancer therapies and indicate that APOE is a candidate biomarker for lung adenocarcinoma metastasis. in Molecular biology reports 2014
Human Polyclonal APOE Primary Antibody for IHC (p), IP - ABIN152926
Atkinson, Blumenstein, Black, Wu, Kasabov, Taylor, Cooper, North: An altered pattern of circulating apolipoprotein E3 isoforms is implicated in preeclampsia. in Journal of lipid research 2008
Human Polyclonal APOE Primary Antibody for IHC (p), IHC - ABIN250408
Dodart, Marr, Koistinaho, Gregersen, Malkani, Verma, Paul: Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease. in Proceedings of the National Academy of Sciences of the United States of America 2005
Human Polyclonal APOE Primary Antibody for IHC (p), WB - ABIN391849
Benga, Krieger, Dimitrova, Zeisel, Parnot, Lupberger, Hildt, Luo, McLauchlan, Baumert, Schuster: Apolipoprotein E interacts with hepatitis C virus nonstructural protein 5A and determines assembly of infectious particles. in Hepatology (Baltimore, Md.) 2009
Human Monoclonal APOE Primary Antibody for FACS, IHC - ABIN965577
Zintzaras, Kitsios, Triposkiadis, Lau, Raman: APOE gene polymorphisms and response to statin therapy. in The pharmacogenomics journal 2009
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results support that there are different vulnerabilities to postnatal CPF (显示 NR5A2 抗体) exposure according to the APOE polymorphism, which in turn affects the cholinergic system and defenses to oxidative stress
forskolin/rolipram incorporated into liposomes, designed to target inflamed endothelium, shows reduced atherosclerosis and CC formation in ApoE -/- mice
exposure to repeated social defeat promotes atherosclerosis by augmenting NETs formation within the plaque in socially defeated apoE(-/-) mice.
In vivo, the NHE6 (显示 SLC9A6 抗体) knockout (NHE6 (显示 SLC9A6 抗体)(KO)) mouse model showed elevated Abeta (显示 APP 抗体) in the brain, consistent with a causal effect. Increased nuclear translocation of histone deacetylase 4 (HDAC4 (显示 HDAC5 抗体)) in ApoE4 astrocytes, compared with the nonpathogenic ApoE3 allele, suggested a mechanistic basis for transcriptional down-regulation of NHE6 (显示 SLC9A6 抗体).
Platelet activation in ApoE and LDLR (显示 LDLR 抗体)-deficient mice was not further increased by strenuous exercise, but was instead attenuated.
the ApoE KO and DKO mice cannot serve as mouse models for studying AD or pathological brain changes compatible with atherosclerosis.
High-fat and high-cholesterol diet induced atherosclerosis faster and more severe than normal diet in ApoE(-/-) mice35
Exenatide enhances adiponectin production and the attenuates atherosclerotic plaque oxidative stress, inflammation, and proteolysis in ApoE(-/-) mice under chronic stress fed high fat diet.
Enhanced mitochondrial oxidative stress under hyperlipidemic conditions in aging induces plaque instability, in part by increasing smooth muscle cell apoptosis, necrotic core expansion, and matrix degradation in Sod2 (显示 SOD2 抗体)/ApoE knockout mice.
Danshensu Bingpian Zhi has antiatherosclerotic effects that involve the inhibition of inflammation, macrophage migration, leukocyte adhesion, and foam cell formation in ApoE-deficient mice.
Site-directed mutagenesis of Akt (显示 AKT1 抗体) at Cys224 revealed that S-nitrosylation at this site was pivotal for the reduced phosphorylation at Akt (显示 AKT1 抗体) Ser473, which led to impaired Akt (显示 AKT1 抗体) signaling. Furthermore, on HHcy challenge, as compared with GSNOR (显示 ADH5 抗体)(+/+)ApoE(-/-) littermate controls, GSNOR (显示 ADH5 抗体)(-/-)ApoE(-/-) double knockout mice showed reduced T-cell activation with concurrent reduction of atherosclerosis.
U.S. military veterans who are APOE epsilon4 allele carriers and exposed to a high number of traumas may be at increased risk for developing PTSD symptoms than epsilon4 noncarriers.
found that the ApoE genotype was significantly associated with aneurysmal subarachnoid hemorrhage risk, whereas its effect on certain ethnic populations differs
APOE polymorphism might be associated with the incidence of aneurysmal subarachnoid hemorrhage in Chinese Fujian Han population.
Reduced expression of miR (显示 MLXIP 抗体)-98 may relate to LOX-1 (显示 OLR1 抗体) expression and foam cell formation and lipid accumulation in aortas of ApoE(-/-) mice.
APOE-epsilon4 modified the association between central arterial stiffening and cognition.
The rs7755 and rs3211956 loci polymorphisms of CD36 (显示 CD36 抗体) gene and genotype E2/E3, E3/E4, E4/E4 of ApoE gene, and E2 and E4 alleles were statistically related with Alzheimer disease.
results show great changes in men carrying ApoE2, mainly in TG and TC concentrations after treatment with hypocaloric diet and controlled exercise
ApoE genetic polymorphisms conferred susceptibility to steroid-induced ONFH in Chinese Han population.
Reduced content of ApoE in blood serum of men with arterial hypertension was associated with APOE4 gene polymorphism.
we report the efficient creation of an APOE knockout rabbit by using zinc finger nucleases. The knockout rabbits had drastically elevated cholesterol and moderately increased triglyceride levels, mimicking symptoms in human heart disease.
The molar ratio ApoE/ApoA-I (显示 APOA1 抗体) is negatively correlated with the enzyme activity, and positively correlated with increases in the intima-media thickness of common carotid wall and cardiac dysfunction signs.
ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL (显示 HSD11B1 抗体) paraoxonase activity
The identification of disulphide-linked apoE dimers in cortical and hippocampal tissues represents a distinct structural difference between the apoE3 and apoE4 isoforms that may have functional consequences.
These data suggest that the -155T>A mutation in the promoter region of the porcine APOE gene is an important functional variant
Nonesterified fatty acids significantly inhibit the expression of ApoB100 (显示 APOB 抗体), ApoE, MTP (显示 MTTP 抗体), and LDLR (显示 LDLR 抗体), thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.
Bovine apoE contents in triglyceride-rich lipoproteins are modulated by nutritional treatment and closely associated with triglyceride-rich lipoprotein metabolism
apoE-containing particles, which increased during the lactating stage, were not associated with HDL (显示 HSD11B1 抗体) particles, and lipid-free forms were included in cow plasma
after calving the apolipoprotein B(100 (显示 APOB 抗体)) mRNA synthesis was lower, whereas microsomal triglyceride transfer protein (MTP (显示 MTTP 抗体)) and apolipoprotein E messenger RNA abundance were higher in the liver
The study found no coding variation within and between chimpanzee populations, suggesting that the maintenance of functionally diverse APOE polymorphisms is a unique feature of human evolution.
ApoE evolution and very likely the evolution of other apolipoproteins are influenced by feeding environment and diet of humans, chimpanzees and various other species.
In the hippocampus APOE protein levels were higher in good spatial performers than poor spatial performers animals
Allele frequencies of the ApoE gene found show that allele epsilon3 has one of the highest frequencies and epsilon4 allele one of the lowest compared to other population groups in the world
There was significantly more apoE immunoreactivity in the prefrontal cortex and hippocampus of aged animals compared to adult or middle-aged animals.
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
, apolipoprotein E3