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Human Monoclonal APOE Primary Antibody for CyTOF, ELISA - ABIN258785
Wahrle, Jiang, Parsadanian, Hartman, Bales, Paul, Holtzman: Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease. in The Journal of biological chemistry 2005
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Human Polyclonal APOE Primary Antibody for IHC, WB - ABIN2774066
Ho, Niti, Yap, Kua, Ng: Metabolic syndrome and cognitive decline in chinese older adults: results from the singapore longitudinal ageing studies. in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2008
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Human Monoclonal APOE Primary Antibody for FACS, IHC - ABIN968962
Karpouzis, Caridha, Tripsianis, Michailidis, Martinis, Veletza: Apolipoprotein E gene polymorphism in psoriasis. in Archives of dermatological research 2009
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Human Polyclonal APOE Primary Antibody for IHC (p), ELISA - ABIN1997537
Li, Jiang, Qu, Yao, Cai, Chen, Peng: Hepatocyte nuclear factor 4? and downstream secreted phospholipase A2 GXIIB regulate production of infectious hepatitis C virus. in Journal of virology 2013
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Human Polyclonal APOE Primary Antibody for IF (p), IHC (p) - ABIN1386767
Liu, Gao, Hao, Lou, Zhang, Li, Wu, Xiao, Yang, Li, Qiu, Wang: Secretomes are a potential source of molecular targets for cancer therapies and indicate that APOE is a candidate biomarker for lung adenocarcinoma metastasis. in Molecular biology reports 2014
Human Polyclonal APOE Primary Antibody for IHC (p), IP - ABIN152926
Atkinson, Blumenstein, Black, Wu, Kasabov, Taylor, Cooper, North: An altered pattern of circulating apolipoprotein E3 isoforms is implicated in preeclampsia. in Journal of lipid research 2008
Mouse (Murine) Polyclonal APOE Primary Antibody for ID, RID - ABIN151509
Terwel, Steffensen, Verghese, Kummer, Gustafsson, Holtzman, Heneka: Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2011
Human Polyclonal APOE Primary Antibody for IHC (p), IHC - ABIN250408
Dodart, Marr, Koistinaho, Gregersen, Malkani, Verma, Paul: Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease. in Proceedings of the National Academy of Sciences of the United States of America 2005
Mouse (Murine) Polyclonal APOE Primary Antibody for IF (p), IHC (p) - ABIN725750
Chiu, Chan, Yang, Liu, Chiang: Supplementation of Chitosan Alleviates High-Fat Diet-Enhanced Lipogenesis in Rats via Adenosine Monophosphate (AMP)-Activated Protein Kinase Activation and Inhibition of Lipogenesis-Associated Genes. in Journal of agricultural and food chemistry 2015
Human Monoclonal APOE Primary Antibody for FACS, IHC - ABIN965577
Zintzaras, Kitsios, Triposkiadis, Lau, Raman: APOE gene polymorphisms and response to statin therapy. in The pharmacogenomics journal 2009
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Enhanced mitochondrial oxidative stress under hyperlipidemic conditions in aging induces plaque instability, in part by increasing smooth muscle cell apoptosis, necrotic core expansion, and matrix degradation in Sod2 (显示 SOD2 抗体)/ApoE knockout mice.
Danshensu Bingpian Zhi has antiatherosclerotic effects that involve the inhibition of inflammation, macrophage migration, leukocyte adhesion, and foam cell formation in ApoE-deficient mice.
Stimulation of nAChRalpha7 with GTS-21 reduced atherosclerosis, which was associated with dampened splenic myelopoiesis in ApoE knockout mice.
Subcutaneous injection of dendritic cells aggravates atherosclerosis in ApoE-knockout mice by activation of TLR4 (显示 TLR4 抗体).
ApoE is essential to the development of cerebral malaria. The protection from ECM (显示 MMRN1 抗体) provided by the deletion of ApoE correlated with decreased sequestration of parasitized RBCs and T cells within the brain and was independent from the involvement of ApoE receptors and from the altered lipid metabolism present in the knock-out mice.
SP-D (显示 SFTPD 抗体) deficiency reduces atherosclerosis in ApoE-knockout mice by decreasing the accumulation and proliferation of macrophages and by reducing IL-6 (显示 IL6 抗体) levels systemically.
The results of this study indicated that ApoE4 negatively impacts BDNF-5-HT2A signaling in the female brain.
The ApoE-/- mice were fed with western-type diet and HSP60 was administrated orally or subcutaneously for potential vaccine against atherosclerosis. ApoE-/- mice with oral HSP60 administration group showed a significant reduction in plaque size at the aortic root; accompanied by increased Myeloid derived suppressor cells (CD11b+Gr1+) in peripheral blood and spleen.
AIM2 (显示 AIM2 抗体) overexpression and inhibition were studied in ApoE-/- mice that were fed a high-fat diet. The results showed that high fat diet increases the expression of AIM2 (显示 AIM2 抗体).
Study observed that in the Apoe-deficient model of atherosclerosis, the female sex is a risk factor to develop more severe atherosclerotic lesions, although serum fat levels are not higher in females than in males. In contrast, female mice are protected from renal damage induced by the concomitant deficiency of Apoe and Itga8.
Overnight hypoxemia and sleepiness were associated with cognition. The average effect estimates were small, similar to effect estimates for several other individual dementia risk factors. Associations were strongest in APOE-epsilon4 risk allele carriers.
Downregulation of apoE and apoJ (显示 CLU 抗体) in CSF (显示 CSF2 抗体) strongly suggests a critical role of lipid metabolism in the development and progression of Moyamoya disease.
ApoE epsilon4 alleles are associated with dementia risk.
APOE4 carriers and the CETP (显示 CETP 抗体) genotype were associated with a decreased response to simvastatin therapy
Results of this study suggest that the process of preclinical Abeta (显示 APP 抗体) pathology might start in early middle age in APOE epsilon4 carriers. Hypothesize that the APOE epsilon4 allele affects CSF (显示 CSF2 抗体) Abeta42 concentrations by speeding up the process of preclinical Abeta (显示 APP 抗体) accumulation and deposition in the brain.
FNDC5 (显示 FNDC5 抗体) gene interactions with candidate genes FOXOA3 and APOE
the role of APOE polymorphisms in retinal vein occlusion
Study used eigenvector centrality mapping to analyze APOE epsilon4-related effects on whole-brain functional connectivity in healthy elderly populations, documented that presence of APOE epsilon4 allele is linked to decreased brain interconnectedness in brain regions susceptible to Alzheimer's disease-related pathology and observed a possible compensatory effect for epsilon4 allele in middle frontal gyrus.
Blood samples were obtained from 30 patients with relapsing-remitting MS (RRMS) along with 30 age and sex-matched healthy individuals, then peripheral blood mononuclear cells (PBMCs) were isolated. The quantitative Real-Time PCR was carried out for Klotho (显示 KL 抗体) mRNA derived from PBMCs. The results showed that klotho (显示 KL 抗体) gene expression in the PBMCs of patients with RRMS is nearly 2.5-fold less than healthy individuals.
The APOE genotyping revealed that epsilon4 allele frequency was significantly high in Alzheimer Disease in a North Indian Population.
we report the efficient creation of an APOE knockout rabbit by using zinc finger nucleases. The knockout rabbits had drastically elevated cholesterol and moderately increased triglyceride levels, mimicking symptoms in human heart disease.
The molar ratio ApoE/ApoA-I (显示 APOA1 抗体) is negatively correlated with the enzyme activity, and positively correlated with increases in the intima-media thickness of common carotid wall and cardiac dysfunction signs.
ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL (显示 HSD11B1 抗体) paraoxonase activity
The identification of disulphide-linked apoE dimers in cortical and hippocampal tissues represents a distinct structural difference between the apoE3 and apoE4 isoforms that may have functional consequences.
These data suggest that the -155T>A mutation in the promoter region of the porcine APOE gene is an important functional variant
Nonesterified fatty acids significantly inhibit the expression of ApoB100 (显示 APOB 抗体), ApoE, MTP (显示 MTTP 抗体), and LDLR (显示 LDLR 抗体), thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.
Bovine apoE contents in triglyceride-rich lipoproteins are modulated by nutritional treatment and closely associated with triglyceride-rich lipoprotein metabolism
apoE-containing particles, which increased during the lactating stage, were not associated with HDL (显示 HSD11B1 抗体) particles, and lipid-free forms were included in cow plasma
after calving the apolipoprotein B(100 (显示 APOB 抗体)) mRNA synthesis was lower, whereas microsomal triglyceride transfer protein (MTP (显示 MTTP 抗体)) and apolipoprotein E messenger RNA abundance were higher in the liver
The study found no coding variation within and between chimpanzee populations, suggesting that the maintenance of functionally diverse APOE polymorphisms is a unique feature of human evolution.
ApoE evolution and very likely the evolution of other apolipoproteins are influenced by feeding environment and diet of humans, chimpanzees and various other species.
In the hippocampus APOE protein levels were higher in good spatial performers than poor spatial performers animals
Allele frequencies of the ApoE gene found show that allele epsilon3 has one of the highest frequencies and epsilon4 allele one of the lowest compared to other population groups in the world
There was significantly more apoE immunoreactivity in the prefrontal cortex and hippocampus of aged animals compared to adult or middle-aged animals.
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
, apolipoprotein E3