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Human GAPDHS Protein expressed in Wheat germ - ABIN1354793
Margaryan, Dorosh, Capkova, Manaskova-Postlerova, Philimonenko, Hozak, Peknicova: Characterization and possible function of glyceraldehyde-3-phosphate dehydrogenase-spermatogenic protein GAPDHS in mammalian sperm. in Reproductive biology and endocrinology : RB&E 2015
GAPDS overexpression antagonize high glucose-induced apoptosis by controlling reactive oxygen species accumulation in TM3 (显示 TPM1 蛋白) cells.
It is assumed that the deficiency in GAPDS observed in most dysplasia of the fibrous sheath sperm samples is ascribable to a disorder in the regulation of GAPDS expression caused by the mutation in the intron region of GAPDS gene.
This result implies that GAPDHS participates in specific signal-transduction pathways.
Structural basis for the NAD binding cooperativity and catalytic characteristics of sperm-specific glyceraldehyde-3-phosphate dehydrogenase (显示 GAPDH 蛋白)
GAPDS protein was expressed in both Sertoli cells and elongated sperms. The expression of GAPDS gradually increased with age in the epididymis.
Data indicate that the positive expression of studied genes fertilization rate for GAPDHS positive subset was 66%, ACR (显示 ACR 蛋白) - 71%, SPATA22 - 68%, MND1 (显示 MND1 蛋白) - 70%, pregnancy rates were 8%, 6%, 18% and 36% respectively.
the expression of GAPDS in melanoma cells may facilitate glycolysis and prevent the induction of apoptosis.
The chaperonin (显示 HSPD1 蛋白) TRiC (显示 MARVELD2 蛋白) was shown to assist an ATP-dependent refolding of recombinant forms of GAPDS.
Structure and kinetic characterization of human sperm-specific glyceraldehyde-3-phosphate dehydrogenase (显示 GAPDH 蛋白), GAPDS.
Human his-GAPDHS expressed in baculovirus-infected insect cells is homotetrameric.
These results identify multiple signaling and metabolic defects that are likely contributors to male infertility and the absence of progressive sperm motility seen in mice lacking GAPDHS.
TB-RBP (显示 TSN 蛋白) is involved in the posttranscriptional regulation of Gapds gene expression during spermiogenesis.
Gapds(-/-) males were infertile and had profound defects in sperm motility, exhibiting sluggish (显示 PRODH 蛋白) movement without forward progression.
This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility.
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
, glyceraldehyde-3-phosphate dehydrogenase, testis-specific-like
, glyceraldehyde-3-phosphate dehydrogenase, testis-specific
, spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2
, spermatogenic glyceraldehyde-3-phosphate dehydrogenase
, glyceraldehyde-3-phosphate dehydrogenase type 2
, glyceraldehyde 3-phosphate dehydrogenase 2
, glyceraldehyde 3-phosphate dehydrogenase, testis-specific