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NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2\; MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration (Sellin et al., 2003
, kin of IRRE-like protein 1
, kin of irregular chiasm-like protein 1
, nephrin-like protein 1
, kin of IRRE like 1
, nephrin 1