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Analysis of interaction surfaces between NEPH1 and MYO1c (显示 MYO1C 蛋白) led to the identification of a critical residue in Neph1 involved in binding to Myo1c (显示 MYO1C 蛋白). Indeed, a point mutant from this site abolished interaction between Neph1 and Myo1c (显示 MYO1C 蛋白).
maintaining high levels of Neph1 at the membrane using a podocyte cell line overexpressing chimeric Neph1 increased the ability of podocytes to resist PAN-induced injury and PAN-induced albumin (显示 ALB 蛋白) leakage
Neph1-CD adopts a global shape in solution, and its interaction with ZO-1 (显示 TJP1 蛋白) involves multiple sites.
Localization of Neph1 to the podocyte cell membrane is altered in the presence of mutant Myo1c (显示 MYO1C 蛋白), and is actin dependent. Knockdown of Myo1c (显示 MYO1C 蛋白) inhibits Neph1 membrane localization. Neph1 is critical for the maintenance of glomerular function.
A striking finding in this study is the lack of contribution of NEPH1, NPHS1, and NPHS2 genes in 15 Asian families with steroid-resistant nephrotic syndrome.
common variants in LRRC7, KIRREL, NPHS2 and ACTN4 (显示 ACTN4 蛋白) do not appeear to contribute to susceptibility to diabetic nephropathy in Finnish patients with type 1 diabetes
Neph1 but not nephrin (显示 NPHS1 蛋白) specifically binds to adaptor protein Grb2 (显示 GRB2 蛋白) and tyrosine kinase (显示 TXK 蛋白) Csk (显示 CSK 蛋白) in a phosphorylation-dependent manner.
Neph1-Nephrin (显示 NPHS1 蛋白) proteins bind the Par3 (显示 F2RL2 蛋白)-Par6 (显示 PARD6A 蛋白)-atypical protein kinase C (显示 PRKCZ 蛋白) (aPKC) complex to regulate podocyte cell polarity
tyrosine phosphorylation of Neph1 mediated by Fyn (显示 FYN 蛋白) results in significantly increased Neph1 and ZO-1 (显示 TJP1 蛋白) binding, suggesting a critical role for Neph1 tyrosine phosphorylation in reorganizing the Neph1-ZO-1 (显示 TJP1 蛋白) complex.
KIRREL was overexpressed in gastric cancer.
Here we demonstrate that Neph1, Neph2, and Neph3 are expressed differentially in various tissues during ontogenesis in mouse and chicken.
Fyn (显示 FYN 蛋白) catalyzes Nephrin (显示 NPHS1 蛋白) phosphorylation in podocyte detergent-resistant membrane fractions.
nephrin (显示 NPHS1 蛋白) and Neph1 interact and have roles in glomerular permeability
In the adult brain, Neph1 is seen in the olfactory nerve layer and the glomerular layer of the olfactory bulb, in the hippocampus, and in cerebellar Purkinje cells. At the ultrastructural level, Neph1 is seen in dendritic shafts of pyramidal neurons.
Nephrin-Neph1 complex transduces phosphorylation-mediated signals that assemble an actin polymerization complex at the podocyte intercellular junction.
NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2\; MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration (Sellin et al., 2003
, kin of IRRE-like protein 1
, kin of irregular chiasm-like protein 1
, nephrin-like protein 1
, kin of IRRE like 1
, nephrin 1