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|抗原||Kin of IRRE Like (Drosophila) (NEPH1) 抗体|
|适用||人, 小鼠, 大鼠 其他选择|
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
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产品细节目标详细情况 使用细节 贮存及处理 图像
|纯化方法||Purified by Protein A.|
|免疫原||KLH conjugated synthetic peptide derived from human KIRREL1/NEPH1|
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|别名||Kirrel1 (NEPH1 Antibody 摘要)|
Neph1(Kirrel) belongs to a family of three closely related transmembrane proteins of the Ig superfamily with a structure similar to that of nephrin. Neph1 consists of a signal peptide, five Ig-like C2-type domains with the middle domain overlapping with a PKD-like domain, an RGD sequence, a transmembrane domain and a cytoplasmic tail. Neph1 is abundantly expressed in the kidney, specifically expressed in podocytes of kidney glomeruli, and plays a significant role in the normal development and function of the glomerular permeability. Neph1 interacts with nephrin in vitro and in vivo, and able to stimulate transcriptional activation in a model system, such as the activation the transcription factor AP-1 via the stimulation of a MAPK module. Neph1 is crucial for the integrity of the slit diaphragm, as Neph1 gene knockout mice results in effacement of glomerular podocytes, heavy proteinuria, and early postnatal death..Tissue specificity:Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli.
Subcellular location: Extracellular
Synonyms: Kin of IRRE like Drosophila,Kin of IRRE like,Kin of IRRE like protein 1,Kin of IRRE-like protein 1,Kin of irregular chiasm like protein 1,Kin of irregular chiasm-like protein 1,KIRR1_HUMAN,Kirrel,MGC129542,MGC129543,NEPH 1,NEPH1,Nephrin like protein 1,Nephrin related,Nephrin-like protein 1,KIRR1_HUMAN.
|途径||Regulation of Actin Filament Polymerization|
使用细节产品细节 目标详细情况 贮存及处理 图像 回页首
贮存及处理产品细节 目标详细情况 使用细节 图像 回页首
|缓冲液||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|注意事项||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|储存方法||Store at 4°C|