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Formin-1 (FMN1) was shown to reside in the nucleus and studies indicate that some formins can shuttle in and out of the nucleus.
actin arcs populating the medial, lamella-like region of the immunological synapse (IS) arise from linear actin filaments generated by one or more formins present at the IS distal edge.
Filopodia initiation: focus on the Arp2 (显示 ACTR2 抗体)/3 complex and formins.
Chromosomal imbalances in the GREM1 (显示 GREM1 抗体) FMN1 region in individuals with limb defects are reported here.
The obtained data indicate the possibility of participation of polymorphism in gene FMN1 in formation of predisposition to prostate cancer.
both mammalian Spir proteins, Spir-1 (显示 SPIRE1 抗体) and Spir-2 (显示 SPIRE1 抗体), interact with mammalian Fmn subgroup proteins formin-1 and formin-2 (显示 FMN2 抗体)
Fmn1 and FlnB (显示 FLNB 抗体) have shared and independent functions.
Results suggest that the regulation of microtubule acetylation is likely a general formin activity.
These results reveal a previously unknown involvement of Formin1 in dendritogenesis and synaptogenesis and indicate that this protein is a key component of the Ngn3 (显示 NEUROG3 抗体) signaling pathway that controls neuronal differentiation.
the mouse formin, FRLalpha, slows actin filament barbed end elongation, competes with capping protein, accelerates polymerization from monomers, and severs filaments
ATP hydrolysis control of filament assembly from profilin (显示 PFN1 抗体)-actin requires formin
It was determined that Fmn1-IV, as an actin nucleator, contributes to protrusion of the cell's leading edge and focal adhesion formation, thus contributing to cell motility
Disruption of Fmn1 gene in mice increased Bmp signaling.
Is important for morphogenesis of limb and kidney and may be involved in determining dorsoventral neural tube polarity and motor neuron induction. It may also have a function in differentiated cells or be involved in maintaining specific differentiated states.
, formin (limb deformity)
, limb deformity protein homolog
, limb deformity protein