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Ccr7 functions during axis formation as a GPCR (显示 GPRC6A ELISA试剂盒) to inhibit beta-catenin (显示 CTNNB1 ELISA试剂盒), likely by promoting Ca(2 (显示 CA2 ELISA试剂盒)+) transients throughout the blastula.
CCR7 deficiency lead to accumulation of CD8 (显示 CD8A ELISA试剂盒)+ adipose tissue leukocytes, which was further exacerbated by HFD feeding.
in the current study, we used interval mapping to validate a locus on Chr 15, named Ity8, linked to Salmonella resistance in AcB60 mice. Global gene expression analysis during infection identified AcB60-specific expression of genes involved in Ccr7 signaling, including downstream effector Mapk11 (mitogen-activated protein kinase 11 (显示 MAPK11 ELISA试剂盒)), located within the Ity8 interval, and representing a potential positional candidate gene
Taken together, these data suggest that CCR7 biases memory CD8 (显示 CD8A ELISA试剂盒) T cells toward IL-7 (显示 IL7 ELISA试剂盒)-dependent niches over IL-15 (显示 IL15 ELISA试剂盒)-dependent niches, which provides insight into the homeostatic regulation of different memory T-cell subsets.
Prominent mucosal immune responses in CCR7-deficient mice increased the efficiency of bacteria clearance from the FRT(female reproductive tract) while reducing tissue-associated inflammation and pathology; increased numbers of lymphocytes within the FRT result in pathogen clearance with reduced immune-mediated pathology
CCR7 is required to mount a robust immune response against enteropathogenic Y. pseudotuberculosis by promoting Th17-like responses in mesenteric lymph nodes.
CCR7 overexpression and RelB (显示 RELB ELISA试剂盒) knockdown (KD) in imDCs improve skin-graft survival in a murine skin-transplantation model. Transfection with Ad-CCR7 and RelB (显示 RELB ELISA试剂盒) KD in imDCs may be an effective approach inducing immune tolerance, thus being potentially valuable for inhibiting allograft rejection.
data point to Ccr7 as a critical host defense restriction factor limiting neuroinflammation during acute West Nile virus infection
The results suggest that CCR7 plays a causal role in maintaining innate and adaptive immunity in obesity.
these data indicate that CCR7 and BTLA (显示 BTLA ELISA试剂盒) cooverexpression imparts an intermediate immune phenotype in mmature dendritic cells when compared to that in CCR7- or BTLA (显示 BTLA ELISA试剂盒)-expressing counterparts that show a more immunocompetent or immunotolerant phenotype
Results suggest that baicalin exerts an inhibitory effect on airway inflammation, and this effect may be associated with the inhibition of CCR7 and its ligands, CCL19 (显示 CCL19 ELISA试剂盒) and CCL21 (显示 CCL21 ELISA试剂盒), as well as on the nuclear factor-Kappa B (NF-kappaB (显示 NFKB1 ELISA试剂盒)) pathway in a mouse model of asthma.
Study shows that miR (显示 MLXIP ELISA试剂盒)-1275 can positively regulate CCR7 expression in squamous cell carcinoma of head and neck (SCCHN) with different mechanisms.
Study provide evidence that CCR7 mediates EMT (显示 ITK ELISA试剂盒) progress via AKT (显示 AKT1 ELISA试剂盒) pathway, which indicates that CCR7 has a key role in breast cancer progression.
Report an increased percentage of peripheral CCR7 T cells accompanied by endothelial dysfunction in patients with ankylosing spondylitis.
The analysis of gene amplification and mRNA levels showed the expression of CCR7 in breast cancer correlated with better prognosis.
that CCR7 mediates TGF-beta1 (显示 TGFB1 ELISA试剂盒)-induced MMP2 (显示 MMP2 ELISA试剂盒)/9 expression through NF-kappaB (显示 NFKB1 ELISA试剂盒) signaling
leukocyte subsets express distinct patterns of CCR7 sialylation that contribute to receptor signaling and fine-tuning chemotactic responses.
tumor microenvironment stimulation down-regulated the migration of CCR7-expressing tumor cells toward CCL21 (显示 CCL21 ELISA试剂盒) and inhibited the formation of directional protrusions toward CCL21 (显示 CCL21 ELISA试剂盒) in a novel 3-dimensional hydrogel system.
CCR7 expression levels in human tumors correlate with signatures of CD141 (显示 THBD ELISA试剂盒)(+) DC, intratumoral T cells, and better clinical outcomes.
specific role for CCL21/CCR7 in promoting EMT and metastasis in CD133+ pancreatic cancer stem-like cells
This study showed that CCR7 are overexpressed in CD4 (显示 CD4 ELISA试剂盒)(-) CD8 (显示 CD8A ELISA试剂盒)(-) thymocytes of myasthenia gravis patients.
Fluorescent dye-labeled gammadelta T cells from afferent and efferent lymph lack CCR7 surface expression and display high levels of CD62L (显示 SELL ELISA试剂盒) compared with CD4 (显示 CD4 ELISA试剂盒) T cells, which do express CCR7.
CCR7 transcripts were minimally expressed in ex vivo and proliferating WC1(+)gammadelta T cells, a unique cell population with proinflammatory characteristics
the pattern of expression of CCR7 in different populations of porcine lymphocytes appears to be similar to that of human, highlighting the value of the pig as a useful animal model for biomedical studies.
Pre-translntation of sertli cell CCR7 significantly suppresses lymphocyte proliferation and prolongs allogeneic skin graft survival.
The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor.
C-C chemokine receptor type 7
, CC chemokine receptor 7
, chemokine (C-C motif) receptor 7 a
, chemokine (C-C motif) receptor 7
, c-C chemokine receptor type 7-like
, C-C CKR-7
, EBV-induced G-protein coupled receptor 1
, MIP-3 beta receptor
, chemokine (C-C) receptor 7
, epstein-Barr virus-induced G-protein coupled receptor 1
, EBV-induced G protein-coupled receptor 1
, Epstein-Barr virus induced G-protein coupled receptor
, Epstein-Barr virus induced gene 1
, lymphocyte-specific G protein-coupled peptide receptor
, chemokine receptor 7