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Human ANGPTL6 Protein expressed in HEK-293 Cells - ABIN1344366
Broxmeyer, Srour, Cooper, Wallace, Hangoc, Youn: Angiopoietin-like-2 and -3 act through their coiled-coil domains to enhance survival and replating capacity of human cord blood hematopoietic progenitors. in Blood cells, molecules & diseases 2012
Poor glycemic control in diabetes mellitus as reflected by higher serum HbA1c levels is associated with raised serum ANGPTL6 levels
ANGPTL6, S100A8 and S100A9 are overexpressed in skin of psoriasis patients versus zero expression in controls.
Data suggest that serum AGF levels are up-regulated in type 2 diabetic patients with lower extremity peripheral arterial disease according to disease severity; patients with highest serum AGF levels exhibit increased cardiovascular mortality and all-cause mortality.
Serum ANGPTL6 levels increased in patients with a hypothyroid status, and both TSH and free T4 levels are associated with ANGPLT6 levels, suggesting a possible association between thyroid function and ANGPTL6 levels.
AGF concentrations is significantly higher in patients with type 2 diabetes as compared to controls.
In the second trimester, Angptl6 levels are higher in women with subsequent pregnancy-induced hypertension.
There are no significant differences in maternal Angptl6/ARP5 serum level between pre-eclamptic women and normally pregnant control women
Serum AGF levels are significantly higher in subjects with polycystic ovary syndrome than those in the healthy control group.
Interaction between alpha6 integrin and E-cadherin (显示 CDH1 蛋白) drives liver metastasis of colorectal cancer cells through hepatic angiopoietin-like 6.
ANGPTL6 affects resting metabolic rate (RMR), significantly improves lipid profile and slightly improves insulin (显示 INS 蛋白) levels and insulin (显示 INS 蛋白) sensitivity, as well.
Since upregulation of ANGPTL6 is induced on metabolic stress, we investigated the hepatic expression of ANGPTL6 by leptin (显示 LEP 蛋白), a representative adipokine of obesity. Mice on a high-fat diet showed increased serum leptin (显示 LEP 蛋白) levels and hepatic Angptl6 expression.
Upregulation of ANGPTL6 in mouse keratinocytes enhances susceptibility to psoriasis.
mitochondrial OXPHOS function governs the expression of ANGPTL6, which is an essential factor for FGF21 (显示 FGF21 蛋白) production in adipose tissue and cultured adipocytes.
In addition to pronounced angiogenesis and epidermal hyperplasia, marked enlargement of dermal lymphatic vessels was observed in UV-B-exposed Angptl6/AGF transgenic mice.
we show that (>80%) of the AGF-deficient mice die at about embryonic day 13, while the surviving AGF-deficient mice develop marked obesity, lipid accumulation in skeletal muscle and liver, and insulin (显示 INS 蛋白) resistance accompanied by reduced energy expenditure
Our results strongly suggest that AGF is an integrin ligand as well as a mitogenic growth factor and theoretically participates in cutaneous wound healing in a more complex mechanism.
Activation of an ERK1/2-eNOS (显示 NOS3 蛋白)-NO pathway is a crucial signaling mechanism by which angiopoietin-related growth factor increases blood flow through induction of angiogenesis and arteriogenesis.
The present results provided evidence that polymorphisms of ANGPTL6 gene were associated with growth and slaughter traits.
developmental expression of Angptl1 (显示 ANGPTL1 蛋白), 2 and 6 in zebrafish
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene.
angiopoietin-like protein 6
, angiopoietin-related growth factor
, angiopoietin-related protein 5
, angiopoietin-related protein 6
, Angiopoietin-related growth factor
, angiopoietin-like protein 6 alpha form
, angiopoietin-like protein 6 beta form
, angiopoietin-like 6
, angiopoietin-related protein 6-like
, ARP3 actin-related protein 3 homolog