STK40 Protein (GST tag,His tag)
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- 抗原 See all STK40 蛋白
- STK40 (serine/threonine Kinase 40 (STK40))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- Baculovirus infected Insect Cells
- 标记
- This STK40 protein is labelled with GST tag,His tag.
- 原理
- Recombinant Human STK40 Protein (His & GST Tag)
- 序列
- Met 1-Lys 435
- 产品特性
- A DNA sequence encoding the human STK40 (NP_114406) (Met1-Lys435) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
- 纯度
- > 97 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product STK40 蛋白
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serine/threonine Kinase 40 (STK40) (AA 1-435) protein (GST tag)
STK40 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
serine/threonine Kinase 40 (STK40) (AA 349-434) protein (GST tag)STK40 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
serine/threonine Kinase 40 (STK40) (AA 1-435) protein (Strep Tag)Crystallography grade STK40 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
serine/threonine Kinase 40 (STK40) (AA 1-435) protein (Strep Tag)Crystallography grade STK40 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
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- 限制
- 仅限研究用
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- 状态
- Frozen, Liquid
- 缓冲液
- Supplied as sterile 20 mM Tris, 500 mM NaCl, 10 % glycerol, 3 mM DTT, 0.5M Urea, 0.5 mM GSH, pH 8.0
- 储存条件
- -20 °C
- 储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- 抗原
- STK40 (serine/threonine Kinase 40 (STK40))
- 别名
- STK40 (STK40 产品)
- 别名
- cb988 Protein, fd99h11 Protein, wu:fd99h11 Protein, NV14115 Protein, DKFZp459J1924 Protein, RP11-268J15.4 Protein, SHIK Protein, SgK495 Protein, 2310004N11Rik Protein, AI428792 Protein, Lyk4 Protein, RGD1307310 Protein, serine/threonine kinase 40 Protein, serine/threonine kinase 40 L homeolog Protein, STK40 Protein, stk40 Protein, LOC100123745 Protein, Stk40 Protein, stk40.L Protein
- 背景
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Background: STK40 localized to both the cytoplasm and the nucleus. It is ubiquitously expressed. Mechanistically, Stk40 interacts with Rcn2, which also activates Erk1/2 to induce ExEn specification in mouse ESCs. Stk40 is able to activate the Erk/MAPK pathway and induce extraembryonic-endoderm (ExEn) differentiation in mouse ESCs. Interestingly, cells overexpressing Stk40 exclusively contribute to the ExEn layer of chimeric embryos when injected into host blastocysts. In contrast, deletion of Stk40 in ESCs markedly reduces ExEn differentiation in vitro. STK40 has a central serine/threonine protein kinase domain and is homologous to TRB-3, a protein that regulates activation of MAP kinases and inhibits NFκB-mediated gene transcription. Similarly, overexpression of STK40 inhibits NFκB activation triggered by TNF and also inhibits p53-mediated transcription. There are four named isoforms of STK40 that are produced as a result of alternative splicing.
Synonym: SgK495;SHIK
- 分子量
- 76.8 kDa
- NCBI登录号
- NP_114406
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