PTPN11 Protein (His tag)
-
- 抗原 See all PTPN11 蛋白
- PTPN11 (Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11))
- 蛋白类型
- Recombinant
- 生物活性
- Active
-
宿主
- 小鼠
-
资源
- HEK-293 Cells
- 标记
- This PTPN11 protein is labelled with His tag.
- 原理
- Recombinant Mouse SHP2/PTPN11 Protein (His Tag)(Active)
- 序列
- Met1-Arg593
- 产品特性
- A DNA sequence encoding the mouse PTPN11 (P35235-2) (Met1-Arg593) was expressed with a C-terminal polyhistidine tag.
- 纯度
- > 90 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to dephosphorylate a tyrosine residue in a peptide containing the EGFR Y992 phosphorylation site (Catalog # ES006).The specific activity is > 1 pmoles/min/μg.
- Top Product
- Discover our top product PTPN11 蛋白
-
Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) (AA 1-460) protein (GST tag)
PTPN11 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) (AA 2-597) protein (His tag)Crystallography grade PTPN11 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) (AA 2-597) protein (His tag)Crystallography grade PTPN11 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) (AA 1-460) protein (His tag)PTPN11 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 90 % by SDS - PAGE SDS
Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) protein (Myc-DYKDDDDK Tag)PTPN11 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
-
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
-
- 抗原
- PTPN11 (Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11))
- 别名
- SHP2/PTPN11 (PTPN11 产品)
- 别名
- BPTP3 Protein, CFC Protein, NS1 Protein, PTP-1D Protein, PTP2C Protein, SH-PTP2 Protein, SH-PTP3 Protein, SHP2 Protein, 2700084A17Rik Protein, AW536184 Protein, PTP1D Protein, SAP-2 Protein, SHP-2 Protein, Shp2 Protein, Syp Protein, SYP Protein, bptp3 Protein, cfc Protein, ns1 Protein, ptp-2 Protein, ptp2c Protein, ptpn11 Protein, ptpn11-a Protein, ptpn11-b Protein, shp-2 Protein, shp2 Protein, fa14b09 Protein, wu:fa14b09 Protein, wu:fi24f03 Protein, zgc:55388 Protein, zgc:63553 Protein, protein tyrosine phosphatase, non-receptor type 11 Protein, protein tyrosine phosphatase, non-receptor type 11 S homeolog Protein, protein tyrosine phosphatase, non-receptor type 11, a Protein, protein tyrosine phosphatase, non-receptor type 11, b Protein, PTPN11 Protein, Ptpn11 Protein, ptpn11.S Protein, ptpn11a Protein, ptpn11b Protein
- 物质类
- Viral Protein
- 背景
-
Background: SHP2, also known as PTPN11, belongs to the protein-tyrosine phosphatase(PTP) family, non-receptor class 2 subfamily. PTPs catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric acid monoesters. They dephosphorylate EGFR, JAK2 and TYK2 kinases, promoting oncogenic transformation. SHP2 is widely expressed, with highest levels in heart, brain, and skeletal muscle. SHP2 acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. It also dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.
Synonym: 2700084A17Rik,AW536184,PTP1D,PTP2C,SAP-2,SH-PTP2,SH-PTP3,SHP-2,Shp2,Syp
- 分子量
- 69.5 kDa
- 途径
- JAK/STAT Signaling, RTK signaling, TCR Signaling, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Toll-Like Receptors Cascades, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals, BCR Signaling, Warburg Effect
-
