TREM2 Protein (AA 19-174) (His tag)
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- 抗原 See all TREM2 蛋白
- TREM2 (Triggering Receptor Expressed On Myeloid Cells 2 (TREM2))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 19-174
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宿主
- Cynomolgus
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资源
- HEK-293 Cells
- 标记
- This TREM2 protein is labelled with His tag.
- 序列
- AA 19-174
- 产品特性
- Mouse TREM2 Protein, Fc Tag
- 纯度
- >90 % as determined by SDS-PAGE.
- 内毒素水平
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product TREM2 蛋白
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Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 19-174) protein (Fc Tag)
TREM2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) protein (His-Avi Tag,Biotin)TREM2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE
Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 19-174) protein (His tag)TREM2 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 19-174) protein (His tag)TREM2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 19-171) protein (His tag)TREM2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) protein (Fc Tag)TREM2 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE
Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 19-161) protein (His tag)TREM2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 1-222) protein (GST tag)TREM2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 19-171) protein (His tag)Crystallography grade TREM2 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 19-230) protein (rho-1D4 tag)Crystallography grade TREM2 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- PBS, pH 7.4
- 储存条件
- -20 °C
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- 抗原
- TREM2 (Triggering Receptor Expressed On Myeloid Cells 2 (TREM2))
- 别名
- TREM2 (TREM2 产品)
- 别名
- TREM-A1 Protein, TREM-B1 Protein, TREM2 Protein, trem-2 Protein, trem2a Protein, trem2b Protein, trem2c Protein, TREM-2 Protein, Trem2a Protein, Trem2b Protein, Trem2c Protein, triggering receptor expressed on myeloid cells 2 Protein, trem-like transcript 2 protein Protein, TREM2 Protein, trem2 Protein, LOC100228399 Protein, Trem2 Protein
- 背景
- Triggering receptor expressed on myeloid cells 2 (TREM2) is a cell surface receptor of the immunoglobulin superfamily. The TREM2 is found in various tissue macrophages, such as CNS microglia, bone osteoclasts, alveolar, peritoneal and intestinal macrophages. TREM2 is also present on cultured bone marrow-derived macrophages and monocyte-derived dendritic cells. Some research have identified a rare variant of TREM2 that is a risk factor for Alzheimer disease (AD), which is the most common form of late-onset dementia.The extracellular region of TREM2 contains a single immunoglobulin superfamily domain and binds polyanionic ligands, such as bacterial lipopolysaccharide (LPS) and phospholipids8. Upon ligand binding, TREM2 transmits intracellular signals through an adaptor, DAP12 (also known as TYRO protein tyrosine kinase-binding protein (TYROBP)), which is associated with the transmembrane region of TREM2 and which recruits the protein tyrosine kinase SYK through its cytosolic immunoreceptor tyrosine-based activation motifs (ITAMs). TREM2 is a pro-tumorigenic marker of tumor-infiltrating macrophages in mouse models and human tumors that can be targeted to curb tumor growth and improve the efficacy of checkpoint blockade therapy while remodeling the landscape of tumor-infiltrating macrophages.
- 分子量
- 19.3 kDa
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