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GPC2 Protein (AA 24-554) (His tag)

GPC2 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
产品编号 ABIN6973078
发货至: 中国
  • 抗原 See all GPC2 蛋白
    GPC2 (Glypican 2 (GPC2))
    蛋白类型
    Recombinant
    生物活性
    Active
    产品特性
    AA 24-554
    宿主
    • 5
    • 3
    • 1
    • 1
    资源
    • 6
    • 2
    • 1
    • 1
    HEK-293 Cells
    标记
    This GPC2 protein is labelled with His tag.
    产品特性
    Human Glypican 2 / GPC2 Protein, His Tag
    纯度
    >90 % as determined by SDS-PAGE.
    内毒素水平
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product GPC2 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    缓冲液
    PBS, pH 7.4
    储存条件
    -20 °C
  • 抗原
    GPC2 (Glypican 2 (GPC2))
    别名
    Glypican 2 (GPC2 产品)
    别名
    2410016G05Rik Protein, glypican 2 Protein, glypican 2 (cerebroglycan) Protein, GPC2 Protein, Gpc2 Protein
    背景
    Glypican 2 (GPC2), also known cerebroglycan, is a glycophosphatidylinositol-linked integral membrane heparan sulfate proteoglycan found in the developing nervous system. Cerebroglycan participates in cell adhesion and is thought to regulate the growth and guidance of axons. Cerebroglycan has especially high affinity for laminin-1. GPC2 silencing inactivates Wnt/β-catenin signaling and reduces the expression of N-Myc, an oncogenic driver of neuroblastoma tumorigenesis. Immunotoxins and chimeric antigen receptor (CAR) T cells targeting GPC2 inhibit neuroblastoma growth in mouse models. A GPC3 specific antibody drug conjugate (ADC) can also inhibit neuroblastoma cell proliferation.
    分子量
    60.0 kDa
    NCBI登录号
    NP_689955
    途径
    Glycosaminoglycan Metabolic Process
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