GPC2 Protein (AA 24-554) (His tag)
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- 抗原 See all GPC2 蛋白
- GPC2 (Glypican 2 (GPC2))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 24-554
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This GPC2 protein is labelled with His tag.
- 产品特性
- Human Glypican 2 / GPC2 Protein, His Tag
- 纯度
- >90 % as determined by SDS-PAGE.
- 内毒素水平
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product GPC2 蛋白
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- PBS, pH 7.4
- 储存条件
- -20 °C
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- 抗原
- GPC2 (Glypican 2 (GPC2))
- 别名
- Glypican 2 (GPC2 产品)
- 别名
- 2410016G05Rik Protein, glypican 2 Protein, glypican 2 (cerebroglycan) Protein, GPC2 Protein, Gpc2 Protein
- 背景
- Glypican 2 (GPC2), also known cerebroglycan, is a glycophosphatidylinositol-linked integral membrane heparan sulfate proteoglycan found in the developing nervous system. Cerebroglycan participates in cell adhesion and is thought to regulate the growth and guidance of axons. Cerebroglycan has especially high affinity for laminin-1. GPC2 silencing inactivates Wnt/β-catenin signaling and reduces the expression of N-Myc, an oncogenic driver of neuroblastoma tumorigenesis. Immunotoxins and chimeric antigen receptor (CAR) T cells targeting GPC2 inhibit neuroblastoma growth in mouse models. A GPC3 specific antibody drug conjugate (ADC) can also inhibit neuroblastoma cell proliferation.
- 分子量
- 60.0 kDa
- NCBI登录号
- NP_689955
- 途径
- Glycosaminoglycan Metabolic Process
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