MRP1 Protein (Fc Tag)
MRP1
宿主: 人
宿主: HEK-293 Cells
Recombinant
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- 抗原 See all MRP1 蛋白
- MRP1 (Macrophage Inflammatory Protein Related Protein 1 (MRP1))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This MRP1 protein is labelled with Fc Tag.
- 序列
- MRP1(Met1-Phe33)+hFc(Glu99-Ala330)
- 产品特性
- Tagged Protein: C-Human Fc tag
- 纯化方法
- affinity purification
- Top Product
- Discover our top product MRP1 蛋白
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Macrophage Inflammatory Protein Related Protein 1 (MRP1) (AA 1248-1531) protein (His tag)
MRP1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Reconstitute with deionized water
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- 储存液
- Without preservative
- 储存条件
- -80 °C
- 储存方法
- Store at -80°C for 12 months (Avoid repeated freezing and thawing)
- 有效期
- 12 months
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- 抗原
- MRP1 (Macrophage Inflammatory Protein Related Protein 1 (MRP1))
- 别名
- MRP1 (MRP1 产品)
- 别名
- Abcc1a Protein, Avcc1a Protein, Mrp Protein, Mrp1 Protein, BTCC-1 Protein, DRAP-27 Protein, MIC3 Protein, MRP-1 Protein, TSPAN-29 Protein, TSPAN29 Protein, Scya6 Protein, c10 Protein, ATP binding cassette subfamily C member 1 Protein, CD9 molecule Protein, chemokine (C-C motif) ligand 6 Protein, Abcc1 Protein, CD9 Protein, Ccl6 Protein
- 背景
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Synonymes: HDMX, MDMX, MRP1
Description: This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011] - 分子量
- 29.15 kDa
- UniProt
- P33527
- 途径
- Response to Water Deprivation, Cell-Cell Junction Organization
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