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SARS-CoV-2 Spike Protein (D614G, Super Stable Trimer) (His tag)

宿主: SARS Coronavirus-2 (SARS-CoV-2) 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE. > 90 % as determined by SEC-MALS. ELISA
产品编号 ABIN6953301
发货至: 中国
  • 抗原 See all SARS-CoV-2 Spike 蛋白
    SARS-CoV-2 Spike
    蛋白类型
    Recombinant
    产品特性
    D614G, Super Stable Trimer
    宿主
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    SARS Coronavirus-2 (SARS-CoV-2)
    资源
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    HEK-293 Cells
    标记
    This SARS-CoV-2 Spike protein is labelled with His tag.
    应用范围
    ELISA
    原理
    SARS-CoV-2 S protein (D614G), His Tag, Super stable trimer (MALS verified)
    产品特性
    SARS-CoV-2 S protein (D614G), His Tag, Super stable trimer is the ectodomain of SARS-CoV-2 S protein that contains AA Val 16 - Pro 1213 (Accession # QHD43416.1) and D614G mutation, which has become increasingly common in SARS-CoV-2 viruses from around the world . The recombinant protein is expressed from human 293 cells (HEK293) with T4 fibritin trimerization motif and a polyhistidine tag at the C-terminus. Proline substitutions (F817P, A892P, A899P, A942P, K986P, V987P) and alanine substitutions (R683A and R685A) are introduced to stabilize the trimeric prefusion state of SARS-CoV-2 S protein and abolish the furin cleavage site, respectively.
    纯度
    > 95 % as determined by SDS-PAGE. > 90 % as determined by SEC-MALS.
    过滤
    0.22 μm filtered
    内毒素水平
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product SARS-CoV-2 Spike 蛋白
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Lyophilized
    缓冲液
    PBS
    储存条件
    -20 °C,-80 °C
    储存方法
    For long term storage, the product should be stored at lyophilized state at -20°C or lower.
    This product is stable after storage at:
    -20°C to -70°C for 12 months in lyophilized state
    70°C for 3 months under sterile conditions after reconstitution.
    有效期
    12 months
  • 抗原
    SARS-CoV-2 Spike
    Abstract
    SARS-CoV-2 Spike 产品
    别名
    E2 Protein, E2 glycoprotein precursor Protein, Surface Glycoprotein Protein, S Protein
    物质类
    Viral Protein
    背景
    It's been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
    分子量
    138.0 kDa
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