IGF1R Protein (AA 31-932) (His tag)
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- 抗原 See all IGF1R 蛋白
- IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))
- 蛋白类型
- Recombinant
- 产品特性
- AA 31-932
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宿主
- Cynomolgus
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资源
- HEK-293 Cells
- 标记
- This IGF1R protein is labelled with His tag.
- 序列
- AA 31-932
- 纯度
- >90 % as determined by SDS-PAGE.
- 内毒素水平
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product IGF1R 蛋白
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Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 31-932) protein (His-Avi Tag)
IGF1R 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 31-932) protein (His-Avi Tag,Biotin)IGF1R 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 959-1367) (Active) protein (GST tag)IGF1R 宿主: 人 宿主: Insect cells (Sf21) Recombinant SDS, Func Active
Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 954-1367) (Active) protein (His-GST)IGF1R 宿主: 人 宿主: Insect cells (Sf9) Recombinant SDS, Func Active
Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 31-932) (Active) protein (His tag)IGF1R 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 741-935) protein (His-IF2DI Tag)IGF1R 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 761-870) protein (GST tag)IGF1R 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 741-935) protein (His-DYKDDDDK-Strep II Tag)IGF1R 宿主: 人 宿主: HEK-293T Cells Recombinant SDS, WB, ELISA, PI
Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 741-935) protein (His tag)Crystallography grade IGF1R 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 742-936) protein (His tag)Crystallography grade IGF1R 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- PBS, pH 7.4
- 注意事项
- Please avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
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- 抗原
- IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))
- 别名
- IGF-I R (IGF1R 产品)
- 别名
- CMT2N Protein, CD221 Protein, IGFIR Protein, IGFR Protein, JTK13 Protein, IGFIRC Protein, IGFR1 Protein, IGF-1R Protein, IGF1R Protein, DKFZp469I0618 Protein, igf-1r Protein, xIGF-1R Protein, xIGFR Protein, xigf1r Protein, A330103N21Rik Protein, D930020L01 Protein, hyft Protein, igf-ir Protein, IGF-IR Protein, IGF-IRb Protein, wu:fb03h06 Protein, IGF-IRa Protein, sb:eu1090 Protein, wu:fi20b10 Protein, alanyl-tRNA synthetase Protein, insulin like growth factor 1 receptor Protein, insulin-like growth factor 1 receptor Protein, insulin-like growth factor 1 Protein, insulin-like growth factor I receptor Protein, insulin like growth factor 1 receptor S homeolog Protein, insulin-like growth factor 1b receptor Protein, insulin-like growth factor 1a receptor Protein, AARS Protein, IGF1R Protein, Igf1r Protein, igf1r Protein, Igf1 Protein, LOC780503 Protein, LOC100136427 Protein, igf1r.S Protein, igf1rb Protein, igf1ra Protein
- 背景
- The Insulin-like Growth Factor 1 Receptor (IGF1) is also known as CD221, JTK13. and is a transmembrane receptor that is activated by IGF-1 and by the related growth factor IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1, which is a polypeptide protein hormone similar in molecular structure to insulin. IGF1R is make up of two alpha subunits and two beta subunits ,the Both the α and β subunits are synthesized from a single mRNA precursor. The precursor is then glycosylated, proteolytically cleaved, and crosslinked by cysteine bonds to form a functional transmembrane αβ chain.The α chains are located extracellularly while the β subunit spans the membrane and are responsible for intracellular signal transduction upon ligand stimulation. IGF1R have a binding site for ATP, which is used to provide the phosphates for autophosphorylation. There is a 60 % homology between IGF1R and the insulin receptor. In response to ligand binding, the α chains induce the tyrosine autophosphorylation of the β chains. This event triggers a cascade of intracellular signaling that, while somewhat cell type specific, often promotes cell survival and cell proliferation.
- 分子量
- 81.1 kDa, 23.8 kDa
- NCBI登录号
- XP_005560632
- 途径
- RTK signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagy
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