SIGIRR Protein (AA 1-118) (Fc Tag)
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- 抗原 See all SIGIRR 蛋白
- SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))
- 蛋白类型
- Recombinant
- 产品特性
- AA 1-118
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This SIGIRR protein is labelled with Fc Tag.
- 原理
- SIGIRR (human):Fc (human) (rec.)
- 特异性
- Signal peptide and extracellular domain of human SIGIRR (aa 1-118) are fused at the C-terminus to the Fc portion of human IgG1.
- 产品特性
- Protein. Signal peptide and extracellular domain of human SIGIRR (aa 1-118) are fused at the C-terminus to the Fc portion of human IgG1. Source: HEK 293 cells. Endotoxin content: <0.06EU/μg purified protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >90 % (SDS-PAGE). SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through a TIR-TIR domain interaction with TLR4.
- 纯度
- >90 % (SDS-PAGE)
- 内毒素水平
- <0.06EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product SIGIRR 蛋白
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Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) (AA 1-410) protein (GST tag)
SIGIRR 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) protein (His tag,Fc Tag)SIGIRR 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) (AA 1-410) protein (Strep Tag)Crystallography grade SIGIRR 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) (AA 1-117) protein (His tag)Crystallography grade SIGIRR 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) (AA 140-410) protein (His tag)Crystallography grade SIGIRR 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) (AA 139-409) protein (His tag)Crystallography grade SIGIRR 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) (AA 1-409) protein (Strep Tag)Crystallography grade SIGIRR 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 浓度
- Lot specific
- 缓冲液
- Lyophilized from 0.2μm-filtered solution in PBS.
- 注意事项
- After reconstitution, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. PBS containing at least 0.1 % BSA should be used for further dilutions.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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- 抗原
- SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))
- 别名
- SIGIRR (SIGIRR 产品)
- 别名
- TIR8 Protein, AI256711 Protein, sc:d148 Protein, RGD1306732 Protein, single Ig and TIR domain containing Protein, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain Protein, SIGIRR Protein, Sigirr Protein, sigirr Protein
- 背景
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Alternate Names/Synonyms: Toll/Interleukin-1 Receptor 8, TIR8, Single Ig IL-1R-related Molecule
Product Description: SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through a TIR-TIR domain interaction with TLR4.
- 途径
- Toll-Like Receptors Cascades
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