LYVE1 Protein (AA 24-228) (Fc Tag)
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- 抗原 See all LYVE1 蛋白
- LYVE1 (Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1))
- 蛋白类型
- Recombinant
- 产品特性
- AA 24-228
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This LYVE1 protein is labelled with Fc Tag.
- 原理
- LYVE-1 (mouse):Fc (mouse) (rec.)
- 特异性
- The extracellular domain of mouse LYVE-1 (aa 24-228) is fused to the N-terminus of the Fc region of mouse IgG2a.
- 产品特性
- Protein. The extracellular domain of mouse LYVE-1 (aa 24-228) is fused to the N-terminus of the Fc region of mouse IgG2a. Source: HEK 293 cells. Endotoxin content: <5EU/mg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). Lymphatic Vessel Endothelial Hyaluronan (HA) Receptor-1 (LYVE-1) is a 60- kDa type I transmembrane glycoprotein that is a member of the Link Protein superfamily. HA is found in the extracellular matrix of most animal tissues and in body fluids. It modulates cell behavior and functions during tissue remodeling, development, homeostasis, and disease. It is often used as a marker of lymphatic endothelia. LYVE-1 is expressed on both the lumenal and ablumenal surfaces of lymphatic endothelium, and also on hepatic blood sinusoidal endothelia. This expression pattern, combined with studies showing that LYVE-1 can support cellular HA internalization in vitro, may suggest LYVE-1 participation in HA internalization for degradation, or transport of HA from tissues into the lumen of lymphatic vessels. LYVE-1-directed HA localization to lymphatic surfaces might also affect aspects of the immune response or tumor metastases. HA binding to CD44 can still occur in the presence of LYVE-1 in vitro. Therefore, LYVE-1-directed HA localization to lymphatics could provide a substrate for transmigrating CD44+ leukocytes or tumor cells. In addition to hepatic and lymphatic endothelia, some expression of LYVE-1 has been reported on Kupffer cells, the islets of Langerhans, cortical neurons, and renal epithelium.
- 纯度
- >98 % (SDS-PAGE)
- 内毒素水平
- <5EU/mg protein (LAL test, Lonza).
- Top Product
- Discover our top product LYVE1 蛋白
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Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1) (AA 1-322) protein (GST tag)
LYVE1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1) (AA 20-238) protein (His tag)Crystallography grade LYVE1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1) (AA 24-234) protein (His tag)Crystallography grade LYVE1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1) (AA 20-322) protein (rho-1D4 tag)Crystallography grade LYVE1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1) (AA 24-318) protein (rho-1D4 tag)Crystallography grade LYVE1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 浓度
- Lot specific
- 缓冲液
- Lyophilized from 0.2μm-filtered solution in PBS.
- 注意事项
- Avoid freeze/thaw cycles.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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- 抗原
- LYVE1 (Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1))
- 别名
- LYVE-1 (LYVE1 产品)
- 别名
- LYVE1 Protein, XLKD1 Protein, CRSBP-1 Protein, HAR Protein, LYVE-1 Protein, 1200012G08Rik Protein, Crsbp-1 Protein, Lyve-1 Protein, Xlkd1 Protein, lymphatic vessel endothelial hyaluronic receptor 1a Protein, lymphatic vessel endothelial hyaluronan receptor 1 Protein, lyve1a Protein, LYVE1 Protein, Lyve1 Protein
- 背景
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Alternate Names/Synonyms: Lymphatic Vessel Endothelial Hyaluronan (HA) Receptor-1
Product Description: Lymphatic Vessel Endothelial Hyaluronan (HA) Receptor-1 (LYVE-1) is a 60- kDa type I transmembrane glycoprotein that is a member of the Link Protein superfamily. HA is found in the extracellular matrix of most animal tissues and in body fluids. It modulates cell behavior and functions during tissue remodeling, development, homeostasis, and disease. It is often used as a marker of lymphatic endothelia. LYVE-1 is expressed on both the lumenal and ablumenal surfaces of lymphatic endothelium, and also on hepatic blood sinusoidal endothelia. This expression pattern, combined with studies showing that LYVE-1 can support cellular HA internalization in vitro, may suggest LYVE-1 participation in HA internalization for degradation, or transport of HA from tissues into the lumen of lymphatic vessels. LYVE-1-directed HA localization to lymphatic surfaces might also affect aspects of the immune response or tumor metastases. HA binding to CD44 can still occur in the presence of LYVE-1 in vitro. Therefore, LYVE-1-directed HA localization to lymphatics could provide a substrate for transmigrating CD44+ leukocytes or tumor cells. In addition to hepatic and lymphatic endothelia, some expression of LYVE-1 has been reported on Kupffer cells, the islets of Langerhans, cortical neurons, and renal epithelium.
- 分子量
- ~70kDa (SDS-PAGE)
- NCBI登录号
- NP_444477
- 途径
- Glycosaminoglycan Metabolic Process
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