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IL1A Protein (AA 113-271) (His tag)

IL1A 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant >98 % (SDS-PAGE)
产品编号 ABIN7278696
发货至: 中国
  • 抗原 See all IL1A 蛋白
    IL1A (Interleukin 1 alpha (IL1A))
    蛋白类型
    Recombinant
    产品特性
    AA 113-271
    宿主
    • 17
    • 12
    • 8
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    资源
    • 38
    • 13
    • 12
    • 2
    • 2
    • 1
    大肠杆菌(E. Coli)
    标记
    This IL1A protein is labelled with His tag.
    原理
    IL-1alpha (human) (rec.) (His)
    特异性
    Human IL-1alpha (aa 113-271) is fused at the C-terminus to a His-tag.
    产品特性
    Protein. Human IL-1alpha (aa 113-271) is fused at the C-terminus to a His-tag. Source: E. coli. Endotoxin content: <0.1EU/μg protein (LAL test, Lonza). Lyophilized from a concentrated sterile solution containing 50  mM Tris-HCl buffer (  pH 8.0) and 100  mM NaCl. Purity: >98 % (SDS-PAGE). The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.
    纯度
    >98 % (SDS-PAGE)
    内毒素水平
    <0.1EU/μg protein (LAL test, Lonza).
    Top Product
    Discover our top product IL1A 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    浓度
    Lot specific
    缓冲液
    Lyophilized from a concentrated sterile solution containing 50  mM Tris-HCl buffer (  pH 8.0) and 100  mM NaCl.
    注意事项
    Avoid freeze/thaw cycles.
    储存条件
    4 °C,-20 °C
    储存方法

    Short Term Storage: +4°C

    Long Term Storage: -20°C

    Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

  • 抗原
    IL1A (Interleukin 1 alpha (IL1A))
    别名
    IL-1alpha (IL1A 产品)
    别名
    IL-1A Protein, IL1 Protein, IL1-ALPHA Protein, IL1F1 Protein, IL-6 Protein, Il-1a Protein, IL-1 alpha Protein, IL-1alpha Protein, L1A Protein, interleukin 1 alpha Protein, interleukin 6 Protein, IL1A Protein, IL6 Protein, Il1a Protein
    背景

    Alternate Names/Synonyms: Interleukin-1alpha, IL-1F1, IL-1A

    Product Description: The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.

    NCBI登录号
    NP_000566
    途径
    NF-kappaB Signaling, Autophagy, Cancer Immune Checkpoints
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