COL18A1 蛋白
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- 抗原 See all COL18A1 蛋白
- COL18A1 (Collagen, Type XVIII, alpha 1 (COL18A1))
- 蛋白类型
- Recombinant
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宿主
- 人
- 宿主
- 请咨询
- 序列
- In total agreement with the expected amino acid compositio n of native human Endostatin
- 产品特性
- Recombinant Human Endostatin
- 纯度
- > 98.0 % as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
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- Discover our top product COL18A1 蛋白
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Collagen, Type XVIII, alpha 1 (COL18A1) protein (His tag)
COL18A1 宿主: 小鼠 宿主: 人细胞 Recombinant > 90 % as determined by SDS-PAGE
Collagen, Type XVIII, alpha 1 (COL18A1) (AA 1572-1754) protein (His tag)Crystallography grade COL18A1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Collagen, Type XVIII, alpha 1 (COL18A1) (AA 1591-1774) protein (His tag)Crystallography grade COL18A1 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Collagen, Type XVIII, alpha 1 (COL18A1) protein (KLH)COL18A1 宿主: 人 宿主: 合成 > 95 % SDS, WB, ELISA, IP
Collagen, Type XVIII, alpha 1 (COL18A1) (Transcript Variant 2) (Active) proteinCOL18A1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining Func, AbP, PI, STD Active
Collagen, Type XVIII, alpha 1 (COL18A1) (AA 1578-1754) protein (GST tag)COL18A1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
Collagen, Type XVIII, alpha 1 (COL18A1) (AA 1578-1754) protein (His tag)COL18A1 宿主: 人 宿主: 酵母菌 Recombinant > 90 % SDS
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- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- The recombinant Human Endostatin is formulated with PBS.
- 储存条件
- -20 °C
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- 抗原
- COL18A1 (Collagen, Type XVIII, alpha 1 (COL18A1))
- 别名
- Endostatin (COL18A1 产品)
- 别名
- KNO Protein, KNO1 Protein, KS Protein, cb371 Protein, cb529 Protein, fc96d06 Protein, sb:cb529 Protein, wu:fb47h10 Protein, wu:fb77g12 Protein, wu:fc50f04 Protein, wu:fc96d06 Protein, wu:fk02h12 Protein, kno Protein, kno1 Protein, collagen type XVIII alpha 1 chain Protein, collagen type XVIII alpha 1 chain a Protein, collagen, type XVIII, alpha 1 Protein, collagen type XVIII alpha 1 Protein, COL18A1 Protein, col18a1a Protein, Col18a1 Protein, col18a1 Protein
- 物质类
- Chemical
- 背景
- Endostatin Human Recombinant produced in Pichia Pastoris is a single, glycosylated, polypeptide having a total molecular mass of 20,000 Dalton C-terminal fragment of collagen XVIII that has been shown to act as a potent inhibitor of angiogenesis and tumor growth in vitro and in vivo. Induces tyrosine phosphorylation of Shc (SH2 domain adapter protein) leading to specific inhibition in endothelial cell proliferation. The Endostatin is purified by proprietary chromatographic techniques. Introduction: Once a cluster of cancer cells reaches a diameter of about 1“2 mm, it must develop a blood supply in order to grow larger. Given that diffusion is no longer adequate to supply the cancerous cells with oxygen and nutrients and to remove wastes. Therefore, these cells secrete substances that promote the formation of new blood vessels (angiogenesis), which are vital for the growth and persistence of solid tumors and their metastases. The production of several angiogenic factors (FGF-a, FGF-b, VEGF and VPF) is upregulated by tumors in order to stimulate angiogenesis. However, numerous malignant tumors also generate inhibitors of angiogenesis which include angiostatin and thrombospondin. The angiogenic phenotype is basically the end result of a net balance between the positive and negative regulators of neovascularization mentioned above. Endostatins role is to inhibit endothelial proliferation, therefore it is an effective angiogenesis inhibitor.
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