BPTP3 Protein, CFC Protein, NS1 Protein, PTP-1D Protein, PTP2C Protein, SH-PTP2 Protein, SH-PTP3 Protein, SHP2 Protein, 2700084A17Rik Protein, AW536184 Protein, PTP1D Protein, SAP-2 Protein, SHP-2 Protein, Shp2 Protein, Syp Protein, SYP Protein, bptp3 Protein, cfc Protein, ns1 Protein, ptp-2 Protein, ptp2c Protein, ptpn11 Protein, ptpn11-a Protein, ptpn11-b Protein, shp-2 Protein, shp2 Protein, fa14b09 Protein, wu:fa14b09 Protein, wu:fi24f03 Protein, zgc:55388 Protein, zgc:63553 Protein, protein tyrosine phosphatase, non-receptor type 11 Protein, protein tyrosine phosphatase, non-receptor type 11 S homeolog Protein, protein tyrosine phosphatase, non-receptor type 11, a Protein, protein tyrosine phosphatase, non-receptor type 11, b Protein, PTPN11 Protein, Ptpn11 Protein, ptpn11.S Protein, ptpn11a Protein, ptpn11b Protein
物质类
Viral Protein
背景
PTPN11, also known as tyrosine-protein phosphatase non-receptor type 11 isoform 2, belongs to the protein-tyrosine phosphatase (PTP) family, non-receptor class 2 subfamily. It participates in signal transduction from the cell surface to the nucleus downstream of various receptor and cytosolic protein tyrosine kinases. This protein deficient cells have poor mobility because excessive phosphorylation of FAK and other proteins interferes with the rotation of cell attachment points in the focal adhesion complex. Recombinant human PTPN11, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
分子量
53.9kDa (469aa) 50-70kDa (SDS-PAGE under reducing conditions)