PPM1D Protein (AA 98-375) (His tag)
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- 抗原 See all PPM1D 蛋白
- PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D))
- 蛋白类型
- Recombinant
- 产品特性
- AA 98-375
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This PPM1D protein is labelled with His tag.
- 应用范围
- SDS-PAGE (SDS)
- 序列
- MGSSHHHHHH SSGLVPRGSH MVAFFAVCDG HGGREAAQFA REHFWGFIKK QKGFTSSEPA KVCAAIRKGF LACHLAMWKK LAEWPKTMTG LPSTSGTTAS VVIIRGMKMY VAHVGDSGVV LGIQDDPKDD FVRAVEVTQD HKPELPKERE RIEGLGGSVM NKSGVNRVVW KRPRLTHNGP VRRSTVIDQI PFLAVARALG DLWSYDFFSG EFVVSPEPDT SVHTLDPQKH KYIILGSDGL WNMIPPQDAI SMCQDQEEKK YLMGEHGQSC AKMLVNRALG RWRQRMLRAD NTSAIVICI
- 纯度
- > 90 % by SDS - PAGE
- Top Product
- Discover our top product PPM1D 蛋白
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Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) (AA 496-605) protein (GST tag)
PPM1D 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) (AA 1-605) protein (GST tag)PPM1D 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) (AA 1-605) protein (Strep Tag)Crystallography grade PPM1D 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) (AA 1-598) protein (Strep Tag)Crystallography grade PPM1D 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) protein (Myc-DYKDDDDK Tag)PPM1D 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 说明
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Denatured
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.5 mg/mL
- 缓冲液
- Liquid, In 20 mM Tris-HCl ( pH 8.0) containing 10 % glycerol
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
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- 抗原
- PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D))
- 别名
- PPM1D (PPM1D 产品)
- 别名
- PP2C-DELTA Protein, WIP1 Protein, AV338790 Protein, Wip1 Protein, zgc:103518 Protein, ppm1d Protein, wu:fj44c08 Protein, zgc:55836 Protein, zgc:77316 Protein, protein phosphatase, Mg2+/Mn2+ dependent 1D Protein, protein phosphatase 1D magnesium-dependent, delta isoform Protein, protein phosphatase, Mg2+/Mn2+ dependent, 1D Protein, protein phosphatase, Mg2+/Mn2+ dependent, 1Db Protein, protein phosphatase, Mg2+/Mn2+ dependent 1D L homeolog Protein, protein phosphatase, Mg2+/Mn2+ dependent, 1Da Protein, PPM1D Protein, Ppm1d Protein, ppm1db Protein, ppm1d.L Protein, ppm1da Protein
- 背景
- PPM1D also known as Protein phosphatase 1D magnesium-dependent, delta isoform. This protein is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase (MAPK/p38) through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. Recombinant human PPM1D, fused to His-tag at N-terminus, was expressed in E.coli.
- 分子量
- 33.2kDa (299aa)
- 途径
- p53 Pathway, Cell Division Cycle
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