PELI2 Protein (AA 1-420) (His tag)
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- 抗原 See all PELI2 蛋白
- PELI2 (Pellino Homolog 2 (Drosophila) (PELI2))
- 蛋白类型
- Recombinant
- 产品特性
- AA 1-420
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This PELI2 protein is labelled with His tag.
- 应用范围
- SDS-PAGE (SDS)
- 序列
- MGSSHHHHHH SSGLVPRGSH MGSMFSPGQE EHCAPNKEPV KYGELVVLGY NGALPNGDRG RRKSRFALYK RPKANGVKPS TVHVISTPQA SKAISCKGQH SISYTLSRNQ TVVVEYTHDK DTDMFQVGRS TESPIDFVVT DTISGSQNTD EAQITQSTIS RFACRIVCDR NEPYTARIFA AGFDSSKNIF LGEKAAKWKN PDGHMDGLTT NGVLVMHPRG GFTEESQPGV WREISVCGDV YTLRETRSAQ QRGKLVESET NVLQDGSLID LCGATLLWRT ADGLFHTPTQ KHIEALRQEI NAARPQCPVG LNTLAFPSIN RKEVVEEKQP WAYLSCGHVH GYHNWGHRSD TEANERECPM CRTVGPYVPL WLGCEAGFYV DAGPPTHAFT PCGHVCSEKS AKYWSQIPLP HGTHAFHAAC PFCATQLVGE QNCIKLIFQG PID
- 纯度
- > 80 % by SDS - PAGE
- Top Product
- Discover our top product PELI2 蛋白
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Pellino Homolog 2 (Drosophila) (PELI2) (AA 1-420) protein (GST tag)
PELI2 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Pellino Homolog 2 (Drosophila) (PELI2) (AA 1-420) protein (Strep Tag)Crystallography grade PELI2 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB
Pellino Homolog 2 (Drosophila) (PELI2) (AA 1-419) protein (Strep Tag)Crystallography grade PELI2 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.5 mg/mL
- 缓冲液
- Liquid. In 20 mM Tris-HCl buffer ( pH 8.0) containing 0.15M NaCl, 20 % glycerol, 1 mM DTT
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
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- 抗原
- PELI2 (Pellino Homolog 2 (Drosophila) (PELI2))
- 别名
- PELI2 (PELI2 产品)
- 别名
- AW047589 Protein, BB129927 Protein, pellino 2 Protein, pellino E3 ubiquitin protein ligase family member 2 Protein, Peli2 Protein, PELI2 Protein
- 背景
- PELI2 is an E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. This protein is involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. It mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. PELI2 may be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. It can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1. Recombinant human PELI2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
- 分子量
- 48.8 kDa (443aa) confirmed by MALDI-TOF
- NCBI登录号
- NP_067078
- UniProt
- Q9HAT8
- 途径
- Activation of Innate immune Response, Toll-Like Receptors Cascades
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