POLR3C Protein (AA 1-534, full length) (His-SUMO Tag)
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- 抗原 See all POLR3C 蛋白
- POLR3C (Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C))
- 蛋白类型
- Recombinant
- 产品特性
- AA 1-534, full length
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This POLR3C protein is labelled with His-SUMO Tag.
- 应用范围
- SDS-PAGE (SDS)
- 序列
- MTQAEIKLCS LLLQEHFGEI VEKIGVHLIR TGSQPLRVIA HDTGTSLDQV KKALCVLVQH NLVSYQVHKR GVVEYEAQCS RVLRMLRYPR YIYTTKTLYS DTGELIVEEL LLNGKLTMSA VVKKVADRLT ETMEDGKTMD YAEVSNTFVR LADTHFVQRC PSVPTTENSD PGPPPPAPTL VINEKDMYLV PKLSLIGKGK RRRSSDEDAA GEPKAKRPKY TTDNKEPIPD DGIYWQANLD RFHQHFRDQA IVSAVANRMD QTSSEIVRTM LRMSEITTSS SAPFTQPLSS NEIFRSLPVG YNISKQVLDQ YLTLLADDPL EFVGKSGDSG GGMYVINLHK ALASLATATL ESVVQERFGS RCARIFRLVL QKKHIEQKQV EDFAMIPAKE AKDMLYKMLS ENFMSLQEIP KTPDHAPSRT FYLYTVNILS AARMLLHRCY KSIANLIERR QFETKENKRL LEKSQRVEAI IASMQATGAE EAQLQEIEEM ITAPERQQLE TLKRNVNKLD ASEIQVDETI FLLESYIECT MKRQ
- 纯化方法
- SDS-PAGE
- 纯度
- > 90 %
- Top Product
- Discover our top product POLR3C 蛋白
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Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C) (AA 1-534) protein (GST tag)
POLR3C 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C) (AA 151-260) protein (GST tag)POLR3C 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C) (AA 1-534) protein (Strep Tag)Crystallography grade POLR3C 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C) (AA 1-533) protein (Strep Tag)Crystallography grade POLR3C 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C) protein (Myc-DYKDDDDK Tag)POLR3C 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.1-2 mg/mL
- 缓冲液
- 20 mM Tris-HCl based buffer, pH 8.0
- 储存条件
- -80 °C,4 °C,-20 °C
- 储存方法
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- 抗原
- POLR3C (Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C))
- 别名
- RPC3 (POLR3C 产品)
- 别名
- rpc3 Protein, rpc62 Protein, 4933407E01Rik Protein, RPC3 Protein, RPC62 Protein, zgc:56348 Protein, polymerase (RNA) III (DNA directed) polypeptide C (62kD) S homeolog Protein, RNA polymerase III subunit C Protein, polymerase (RNA) III (DNA directed) polypeptide C (62kD) Protein, polymerase (RNA) III (DNA directed) polypeptide C Protein, polr3c.S Protein, POLR3C Protein, polr3c Protein, Polr3c Protein
- 背景
- DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other mbers of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as tplate for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.
- 分子量
- 76.6 kDa
- UniProt
- Q9BUI4
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