PLA2R1 Protein (AA 395-530, partial) (His tag)
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- 抗原 See all PLA2R1 蛋白
- PLA2R1 (phospholipase A2 Receptor 1, 180kDa (PLA2R1))
- 蛋白类型
- Recombinant
- 产品特性
- AA 395-530, partial
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This PLA2R1 protein is labelled with His tag.
- 应用范围
- SDS-PAGE (SDS)
- 序列
- EEKTWHEALR SCQADNSALI DITSLAEVEF LVTLLGDENA SETWIGLSSN KIPVSFEWSN DSSVIFTNWH TLEPHIFPNR SQLCVSAEQS EGHWKVKNCE ERLFYICKKA GHVLSDAESG CQEGWERHGG FCYKID
- 纯化方法
- SDS-PAGE
- 纯度
- > 90 %
- Top Product
- Discover our top product PLA2R1 蛋白
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phospholipase A2 Receptor 1, 180kDa (PLA2R1) (AA 21-1397) protein (His tag)
Crystallography grade PLA2R1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
phospholipase A2 Receptor 1, 180kDa (PLA2R1) (AA 27-1396) protein (His tag)Crystallography grade PLA2R1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
phospholipase A2 Receptor 1, 180kDa (PLA2R1) (AA 21-1463) protein (rho-1D4 tag)Crystallography grade PLA2R1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
phospholipase A2 Receptor 1, 180kDa (PLA2R1) (AA 27-1487) protein (rho-1D4 tag)Crystallography grade PLA2R1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
phospholipase A2 Receptor 1, 180kDa (PLA2R1) (AA 395-530) protein (His tag)PLA2R1 宿主: 人 宿主: 酵母菌 Recombinant > 90 % SDS
phospholipase A2 Receptor 1, 180kDa (PLA2R1) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)PLA2R1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.1-2 mg/mL
- 缓冲液
- 20 mM Tris-HCl based buffer, pH 8.0
- 储存条件
- -80 °C,4 °C,-20 °C
- 储存方法
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- 抗原
- PLA2R1 (phospholipase A2 Receptor 1, 180kDa (PLA2R1))
- 别名
- PLA2R (PLA2R1 产品)
- 别名
- Pla2-r Protein, Pla2g1br Protein, Pla2r Protein, CLEC13C Protein, PLA2-R Protein, PLA2G1R Protein, PLA2IR Protein, PLA2R Protein, phospholipase A2 receptor 1 Protein, PLA2R1 Protein, Pla2r1 Protein
- 背景
- Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function rains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B.
- 分子量
- 19.6 kDa
- UniProt
- Q13018
- 途径
- Positive Regulation of Response to DNA Damage Stimulus
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