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SLIT2 Protein (DYKDDDDK Tag)

SLIT2 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % (SDS-PAGE) SDS Active
产品编号 ABIN5564488
发货至: 中国
  • 抗原 See all SLIT2 蛋白
    SLIT2 (Slit Homolog 2 (Drosophila) (SLIT2))
    蛋白类型
    Recombinant
    生物活性
    Active
    宿主
    • 10
    • 5
    • 3
    资源
    • 7
    • 6
    • 3
    • 1
    • 1
    HEK-293 Cells
    标记
    This SLIT2 protein is labelled with DYKDDDDK Tag.
    应用范围
    SDS-PAGE (SDS)
    交叉反应
    产品特性
    Human Slit2 (aa 1122-1529) is fused at the C-terminus to a FLAG®-tag.
    纯度
    >95 % (SDS-PAGE)
    内毒素水平
    <0.01EU/μg purified protein (LAL test, Lonza).
    Top Product
    Discover our top product SLIT2 蛋白
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    说明

    Activates an UCP1-luciferase construct in mouse fat primary cells at a concentration of 20nM.

    限制
    仅限研究用
  • 状态
    Solid
    浓度
    Lot specific
    缓冲液
    Lyophilized. Contains PBS.
    储存条件
    4 °C,-20 °C
    储存方法
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 6 months after receipt when stored at -20°C.
    有效期
    6 months
  • 抗原
    SLIT2 (Slit Homolog 2 (Drosophila) (SLIT2))
    别名
    Slit2 (SLIT2 产品)
    别名
    SLIL3 Protein, Slit-2 Protein, Drad-1 Protein, E030015M03Rik Protein, E130320P19Rik Protein, Slil3 Protein, mKIAA4141 Protein, Slit Protein, slil3 Protein, slit-2 Protein, slit2-a Protein, SLIT2 Protein, slit guidance ligand 2 Protein, slit homolog 2 (Drosophila) Protein, slit guidance ligand 2 S homeolog Protein, SLIT2 Protein, Slit2 Protein, slit2 Protein, slit2.S Protein
    背景
    The Slits are secreted proteins that bind to Robo receptors and play a role in axon guidance and neuronal migration. The Slit family in mice and humans comprises three members: Slit1, Slit2 and Slit3. These are all extracellular matrix proteins of 180-200 kDa. In vivo, Slit2 is cleaved into 140 kDa N-terminal (Slit2-N) and 55-60 kDa C-terminal (Slit2-C) fragments. Only Slit2-N and Slit2 full-length bind the Robo proteins. Recently, it has been shown that Slit2 is highly expressed in adipose tissues under the control of PRDM16 and cold exposure. Slit2 is posttranslationally cleaved by adipocytes and the resulting Slit2-C fragment improves glucose homeostasis in mice by activating a thermogenic PKA/cAMP pathway not mediated by beta-adrenergic receptors in adipocytes.
    分子量
    ~55kDa
    UniProt
    O94813
    途径
    Regulation of Actin Filament Polymerization, Regulation of Cell Size, Smooth Muscle Cell Migration
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