PDCD1LG2
(Programmed Cell Death 1 Ligand 2 (PDCD1LG2))
蛋白类型
Recombinant
产品特性
AA 20-219
宿主
小鼠
资源
HEK-293 Cells
标记
This PDCD1LG2 protein is labelled with Fc Tag.
应用范围
Functional Studies (Func)
序列
AA 20-219
产品特性
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 49.2 kDa. As a result of glycosylation, the protein migrates as 60-70 kDa under reducing (R) condition, and 120-140 kDa under non-reducing (NR) condition (SDS-PAGE).
Programmed cell death 1 ligand 2 (PD-L2 or PDCD1 ligand 2) is also known as Butyrophilin B7-DC, CD antigen CD273, which belongs to the immunoglobulin superfamily or BTN/MOG family. The expression of PD-L2 is up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL-4. PD-L2 Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. PD-L2 interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.