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CD3 epsilon Protein (CD3E) (AA 23-108) (Fc Tag)

CD3E 宿主: 小鼠 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func
产品编号 ABIN4949162
发货至: 中国
  • 抗原 See all CD3 epsilon (CD3E) 蛋白
    CD3 epsilon (CD3E)
    蛋白类型
    Recombinant
    产品特性
    AA 23-108
    宿主
    • 25
    • 9
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    小鼠
    资源
    • 22
    • 8
    • 5
    • 5
    • 2
    • 2
    HEK-293 Cells
    标记
    This CD3 epsilon protein is labelled with Fc Tag.
    应用范围
    Functional Studies (Func)
    序列
    AA 23-108
    产品特性
    This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 36 kDa. The protein migrates as 45 kDa under reducing (R) condition (SDS-PAGE).
    纯度
    >95 % as determined by SDS-PAGE.
    内毒素水平
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product CD3E 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    缓冲液
    Tris with Glycine, Arginine and NaCl,  pH 7.5
    注意事项
    Please avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
  • 抗原
    CD3 epsilon (CD3E)
    别名
    CD3 epsilon (CD3E 产品)
    别名
    cd3e Protein, CD3E Protein, t3e Protein, tcre Protein, AI504783 Protein, CD3 Protein, CD3epsilon Protein, T3e Protein, T3E Protein, TCRE Protein, CD3e molecule Protein, CD3 antigen, epsilon polypeptide Protein, cd3e Protein, CD3E Protein, Cd3e Protein
    背景
    CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.
    分子量
    36 kDa
    UniProt
    P22646
    途径
    TCR Signaling, CXCR4-mediated Signaling Events, Ubiquitin Proteasome Pathway
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