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BAFF Protein (AA 134-285) (His tag,AVI tag,Biotin)

TNFSF13B 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active
产品编号 ABIN4949008
发货至: 中国
  • 抗原 See all BAFF (TNFSF13B) 蛋白
    BAFF (TNFSF13B) (Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B))
    蛋白类型
    Recombinant
    生物活性
    Active
    产品特性
    AA 134-285
    宿主
    • 36
    • 15
    • 3
    • 2
    • 2
    资源
    • 20
    • 19
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    HEK-293 Cells
    标记
    This BAFF protein is labelled with His tag,AVI tag,Biotin.
    应用范围
    Functional Studies (Func)
    品牌
    MABSol®,PrecisionAvi
    序列
    AA 134-285
    特异性
    Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.
    产品特性
    This protein carries a polyhistidine tag at the N-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 29.2 kDa. As a result of glycosylation, the protein migrates as 29 kDa under reducing (R) condition, and 58 kDa under non-reducing (NR) condition (SDS-PAGE).
    纯度
    >95 % as determined by SDS-PAGE.
    内毒素水平
    Less than 1.0 EU per μg by the LAL method.
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    Discover our top product TNFSF13B 蛋白
  • 说明

    Ready-to-use AvitagTM biotinylated protein:
    The product is exclusively produced using the AvitagTM technology. Briefly, a unique 15 amino acid peptide, the Avi tag, is introduced into the recombinant protein during expression vector construction. The single lysine residue in the Avi tag is enzymatically biotinylated by the E. Coli biotin ligase BirA.

    This single-point enzymatic labeling technique brings many advantages for commonly used binding assays. The biotinylation happens on the lysine residue of Avi tag, and therefore does NOT interfere with the target protein's natural binding activities. In addition, when immobilized on an avidin-coated surface, the protein orientation is uniform because the position of the Avi tag in the protein is precisely controlled.

    限制
    仅限研究用
  • 状态
    Lyophilized
    缓冲液
    PBS, pH 7.4
    注意事项
    Please avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
  • 抗原
    BAFF (TNFSF13B) (Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B))
    别名
    BAFF (TNFSF13B 产品)
    别名
    BAFF Protein, BLYS Protein, CD257 Protein, DTL Protein, TALL-1 Protein, TALL1 Protein, THANK Protein, TNFSF20 Protein, ZTNF4 Protein, BAFF-R Protein, BAFFR Protein, BROMIX Protein, CD268 Protein, CVID4 Protein, prolixin Protein, TNFSF13B Protein, RGD1561519 Protein, RGD1560810 Protein, BLyS Protein, D8Ertd387e Protein, zTNF4 Protein, 2010006P15Rik Protein, Baffr Protein, Bcmd Protein, Bcmd-1 Protein, Bcmd1 Protein, Lvis22 Protein, zgc:172115 Protein, TNF superfamily member 13b Protein, TNF receptor superfamily member 13C Protein, tumor necrosis factor (ligand) superfamily, member 13b Protein, tumor necrosis factor receptor superfamily, member 13c Protein, tumor necrosis factor superfamily member 13b Protein, TNFSF13B Protein, TNFRSF13C Protein, Tnfsf13b Protein, Tnfrsf13c Protein, tnfsf13b Protein
    背景
    B-cell activating factor (BAFF) is also known as tumor necrosis factor ligand superfamily member 13B , TNFSF13B, BAFF, B Lymphocyte Stimulator (BLyS) , cluster of differentiation 257 (CD257), DTL, TNF- and APOL-related leukocyte expressed ligand (TALL-1), THANK, TNFSF20, ZTNF4, and is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. It is expressed as transmembrane protein on various cell types including monocytes, dendritic cells and bone marrow stromal cells. BAFF is the natural ligand of three unusual tumor necrosis factor receptors named BAFF-R, TACI, and BCMA, all of which have differing binding affinities for it. These receptors are expressed mainly on mature B lymphocytes (TACI is also found on a subset of T-cells and BCMA on plasma cells). TACI binds worst since its affinity is higher for a protein similar to BAFF, called a proliferation-inducing ligand (APRIL). BCMA displays an intermediate binding phenotype and will work with either BAFF or APRIL to varying degrees. Signaling through BAFF-R and BCMA stimulates B lymphocytes to undergo proliferation and to counter apoptosis. All these ligands act as heterotrimers (i.e. three of the same molecule) interacting with heterotrimeric receptors, although BAFF has been known to be active as either a hetero- or homotrimer. BAFF acts as a potent B cell activator and has been shown to play an important role in the proliferation and differentiation of B cells. 
    分子量
    20.2 kDa
    途径
    NF-kappaB Signaling, Production of Molecular Mediator of Immune Response
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