Wingless-Type MMTV Integration Site Family, Member 1 (WNT1) (Active) 蛋白

ABIN413893 产品详细信息, 供应商: Log in to see
  • Xint-1
  • Xwnt1
  • int-1
  • int1
  • wnt-1
  • wnt1-a
  • Int-1
  • Wnt-1
  • sw
  • swaying
  • BMND16
  • INT1
  • OI15
  • Int1
  • WNT-1
  • sb:eu647
  • zgc:194464
  • zgc:194478
  • WNT1
  • Wnt family member 1
  • Wnt family member 1 L homeolog
  • wingless-type MMTV integration site family, member 1
  • WNT1
  • wnt1.L
  • Wnt1
  • wnt1

大肠杆菌(E. Coli)
High Pressure Liquid Chromatography (HPLC), SDS-PAGE (SDS)
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纯度 ≥98 % by SDS-PAGE
≥98 % by HPLC
过滤 Sterile filtered
内毒素水平 <0.1 ng/μg
Biological Activity Comment The ED₅₀ was determined by its ability to enhance BMP-2 induced alkaline phosphatase production by murine ATDC5 cells. The expected ED₅₀ for this effect is 1.5 - 2.5 ng/ml in the presence of 200 ng/ml of human BMP-2.
背景 Wnt-1 is a secreted protein that signals through the Frizzled family of cell surface receptors and is required for normal embryonic development. Wnt-1 activation induces a complex signaling cascade that ultimately leads to the increased expression of over fifty genes. An important component of Wnt-1 signaling is the stabilization, and resulting accumulation, of the intraCellular signaling protein, β-catenine. Wnt signaling induces and maintains the transformed phenotype and, in certain embryonic cell lines, supports self renewal in the absence of significant differentiation. Elevated levels of Wnt proteins are associated with tumorigenesis and are present in numerous human breast cancers. Mature human Wnt-1 is a glycosylated protein containing 343 amino acid residues. Recombinant human Wnt-1 is a 38.4 kDa, non-glycosylated protein containing 343 amino acid residues.

Alternative Names: INT-1, Proto-oncogene Int-1 homolog
分子量 38.4 kDa
基因ID 7471
UniProt P04628
途径 WNT signaling, Dopaminergic Neurogenesis
应用备注 Optimal working dilution should be determined by the investigator.
限制 仅限研究用
状态 Lyophilized
溶解方式 Reconstitute in H₂O to a concentration of 0.1-1.0 μg/μl. The solution can then be diluted into other aqueous buffers
缓冲液 Sterile filtered and lyophilized with no additives
储存液 Without preservative
注意事项 Centrifuge the vial prior to opening.
储存条件 -20 °C
有效期 12 months
Western Blotting (WB) image for Wingless-Type MMTV Integration Site Family, Member 1 (WNT1) (Active) protein (ABIN413893) Wingless-Type MMTV Integration Site Family, Member 1 (WNT1) (Active) protein
有引用在: Reuter, Martin, Beckert, Bros, Montermann, Belz, Heinz, Ohngemach, Sahin, Stassen, Buhl, Eshkind, Taube: "The Wnt/β-catenin pathway attenuates experimental allergic airway disease." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 193, Issue 2, pp. 485-95, 2014 (PubMed).

Tawk, Makoukji, Belle, Fonte, Trousson, Hawkins, Li, Ghandour, Schumacher, Massaad: "Wnt/beta-catenin signaling is an essential and direct driver of myelin gene expression and myelinogenesis." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 31, Issue 10, pp. 3729-42, 2011 (PubMed).