CRTAM Protein (AA 18-287) (Fc Tag)
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- 抗原 See all CRTAM 蛋白
- CRTAM (Cytotoxic and Regulatory T Cell Molecule (CRTAM))
- 蛋白类型
- Recombinant
- 产品特性
- AA 18-287
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宿主
- Cynomolgus
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资源
- HEK-293 Cells
- 标记
- This CRTAM protein is labelled with Fc Tag.
- 序列
- AA 18-287
- 产品特性
- This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 56.6 kDa. The protein migrates as 85-95 kDa under reducing (R) condition (SDS-PAGE).
- 纯度
- >90 % as determined by SDS-PAGE.
- 内毒素水平
- Less than 1.0 EU per μg by the LAL method.
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- Discover our top product CRTAM 蛋白
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Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 18-287) protein (Fc Tag)
CRTAM 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 18-287) protein (His tag)CRTAM 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 18-287) protein (His tag)CRTAM 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 17-289) protein (His tag)CRTAM 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 18-287) protein (His tag)CRTAM 宿主: 犬 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 1-393) protein (GST tag)CRTAM 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 17-285) protein (His tag)Crystallography grade CRTAM 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 18-393) protein (rho-1D4 tag)Crystallography grade CRTAM 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 17-389) protein (rho-1D4 tag)Crystallography grade CRTAM 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- Tris with Glycine, Arginine and NaCl, pH 7.5
- 注意事项
- Please avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
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- 抗原
- CRTAM (Cytotoxic and Regulatory T Cell Molecule (CRTAM))
- 别名
- CRTAM (CRTAM 产品)
- 别名
- TAD Protein, cTADS Protein, MGC82176 Protein, CRTAM Protein, CD355 Protein, cytotoxic and regulatory T-cell molecule Protein, cytotoxic and regulatory T-cell molecule L homeolog Protein, cytotoxic and regulatory T cell molecule Protein, CRTAM Protein, crtam.L Protein, Crtam Protein
- 背景
- Class I-restricted T cell-associated molecule (CRTAM), a member of nectin family and the immunoglobulin superfamily, is also known as cytotoxic and regulatory T-cell molecule, which is expressed by activated CD8+ and NK T cells. CRTAM is found in spleen, thymus, small intestine, peripheral blood, and surprisingly, in brain where it is highly expressed by Purkinje cells of the cerebellum. The high affinity of CRTAM/IGSF4 adhesion allows CRTAM to disrupt IGSF4 homotypic interactions (3 - 5). IGSF4 and T cell receptor co-engagement of CRTAM-expressing CD8+ cells induces increased IFN-gamma or IL-22 production (3, 4). Furthermore, a role in cancer surveillance through NK cell-mediated rejection of IGSF4-expressing tumors has been proposed.
- 分子量
- 56.6 kDa
- NCBI登录号
- XP_005580021
- 途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
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