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FcRn Protein (AA 23-298) (His tag,Strep Tag,AVI tag,Biotin)

FcRn 宿主: 大鼠 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
产品编号 ABIN2870582
发货至: 中国
  • 抗原 See all FcRn 蛋白
    FcRn (IgG receptor FcRn (FcRn))
    蛋白类型
    Recombinant
    生物活性
    Active
    产品特性
    AA 23-298
    宿主
    • 16
    • 6
    • 5
    • 3
    • 2
    • 1
    大鼠
    资源
    • 18
    • 4
    • 3
    • 3
    • 1
    • 1
    HEK-293 Cells
    标记
    This FcRn protein is labelled with His tag,Strep Tag,AVI tag,Biotin.
    品牌
    MABSol®,PrecisionAvi
    序列
    AA 23-298
    特异性
    Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.
    产品特性
    The subunit FCGRT carries an Avi tag (Avitag™) at the C-terminus, followed by a polyhistidine tag. The subunit Beta-2 microglobulin (B2M) carries a Strep II tag at the C-terminus. The protein has a calculated MW of 34.7 kDa (FCGRT), 13.1 kDa (B2M) . The protein migrates as 45-50 kDa (FCGRT), 14 kDa (B2M) respectively on a SDS-PAGE gel under reducing (R) condition due to glycosylation.
    纯度
    >95 % as determined by SDS-PAGE.
    内毒素水平
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product FcRn 蛋白
  • 说明

    Ready-to-use AvitagTM biotinylated protein:
    The product is exclusively produced using the AvitagTM technology. Briefly, a unique 15 amino acid peptide, the Avi tag, is introduced into the recombinant protein during expression vector construction. The single lysine residue in the Avi tag is enzymatically biotinylated by the E. Coli biotin ligase BirA.

    This single-point enzymatic labeling technique brings many advantages for commonly used binding assays. The biotinylation happens on the lysine residue of Avi tag, and therefore does NOT interfere with the target protein's natural binding activities. In addition, when immobilized on an avidin-coated surface, the protein orientation is uniform because the position of the Avi tag in the protein is precisely controlled.

    限制
    仅限研究用
  • 状态
    Lyophilized
    缓冲液
    PBS, pH 7.4
    注意事项
    Please avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
  • 抗原
    FcRn (IgG receptor FcRn (FcRn))
    别名
    FcRn (FcRn 产品)
    别名
    FCRN Protein, alpha-chain Protein, FcRn Protein, Fc fragment of IgG receptor and transporter Protein, Fc receptor, IgG, alpha chain transporter Protein, FCGRT Protein, Fcgrt Protein
    背景
    FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51 (equivalent to FCGRT), and p14 (equivalent to beta-2-microglobulin), and forms an MHC class I-like heterodimer. Fc fragment of IgG, receptor, transporter, alpha (FCGRT) binds to the Fc region of monomeric immunoglobulins gamma and mediates the uptake of IgG from milk. FCGRT possible role in transfer of immunoglobulin G from mother to fetus. Beta-2-microglobulin (B2M) is a component of the class I major histocompatibility complex (MHC) and involved in the presentation of peptide antigens to the immune system.
    分子量
    34.7 kDa (FCGRT), 13.1 kDa (B2M)
    途径
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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