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RAD18 Protein (Myc-DYKDDDDK Tag)

RAD18 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
产品编号 ABIN2730398
发货至: 中国
  • 抗原 See all RAD18 蛋白
    RAD18 (E3 ubiquitin-protein ligase RAD18 (RAD18))
    蛋白类型
    Recombinant
    宿主
    • 4
    • 1
    资源
    • 2
    • 2
    • 1
    HEK-293 Cells
    标记
    This RAD18 protein is labelled with Myc-DYKDDDDK Tag.
    应用范围
    Antibody Production (AbP), Standard (STD)
    产品特性
    • Recombinant human RAD18 / RNF73 protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    纯度
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product RAD18 蛋白
  • 应用备注
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    说明

    The tag is located at the C-terminal.

    限制
    仅限研究用
  • 浓度
    50 μg/mL
    缓冲液
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    储存条件
    -80 °C
    储存方法
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Zlatanou, Sabbioneda, Miller, Greenwalt, Aggathanggelou, Maurice, Lehmann, Stankovic, Reverdy, Colland, Vaziri, Stewart: "USP7 is essential for maintaining Rad18 stability and DNA damage tolerance." in: Oncogene, Vol. 35, Issue 8, pp. 965-76, (2016) (PubMed).

  • 抗原
    RAD18 (E3 ubiquitin-protein ligase RAD18 (RAD18))
    别名
    Rad18,rnf73 (RAD18 产品)
    别名
    RNF73 Protein, 2810024C04Rik Protein, Rad18sc Protein, zgc:55577 Protein, RAD18 Protein, DDBDRAFT_0218120 Protein, DDBDRAFT_0304878 Protein, DDB_0218120 Protein, DDB_0304878 Protein, DKFZp469H0810 Protein, RAD18, E3 ubiquitin protein ligase Protein, RAD18 E3 ubiquitin protein ligase Protein, E3 ubiquitin-protein ligase RAD18 Protein, E3 ubiquitin-protein ligase Protein, DNA repair protein and ATPase Protein, C3HC4-type zinc finger-containing protein Protein, RAD18 Protein, Rad18 Protein, rad18 Protein
    背景
    The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens.
    分子量
    56 kDa
    NCBI登录号
    NP_064550
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