Presenilin 1 Protein (PSEN1) (Transcript Variant 1) (Myc-DYKDDDDK Tag)
-
- 抗原 See all Presenilin 1 (PSEN1) 蛋白
- Presenilin 1 (PSEN1)
- 蛋白类型
- Recombinant
- 产品特性
- Transcript Variant 1
-
宿主
- 人
-
资源
- HEK-293 Cells
- 标记
- This Presenilin 1 protein is labelled with Myc-DYKDDDDK Tag.
- 应用范围
- Antibody Production (AbP), Standard (STD)
- 产品特性
-
- Recombinant human Presenilin-1 (transcript variant 1) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- 纯度
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product PSEN1 蛋白
-
Presenilin 1 (PSEN1) (AA 280-379) protein (GST tag)
PSEN1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Presenilin 1 (PSEN1) (AA 265-380) protein (His tag)Crystallography grade PSEN1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Presenilin 1 (PSEN1) (AA 265-380) protein (His tag)Crystallography grade PSEN1 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Presenilin 1 (PSEN1) (AA 1-298) protein (rho-1D4 tag)Crystallography grade PSEN1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Presenilin 1 (PSEN1) (AA 299-467) protein (rho-1D4 tag)Crystallography grade PSEN1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Presenilin 1 (PSEN1) (AA 346-467) protein (rho-1D4 tag)Crystallography grade PSEN1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Presenilin 1 (PSEN1) (AA 1-298) protein (rho-1D4 tag)Crystallography grade PSEN1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Presenilin 1 (PSEN1) (AA 299-467) protein (rho-1D4 tag)Crystallography grade PSEN1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Presenilin 1 (PSEN1) (AA 346-467) protein (rho-1D4 tag)Crystallography grade PSEN1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
-
- 应用备注
-
Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - 说明
-
The tag is located at the C-terminal.
- 限制
- 仅限研究用
-
- 浓度
- 50 μg/mL
- 缓冲液
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- 储存条件
- -80 °C
- 储存方法
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
-
- 抗原
- Presenilin 1 (PSEN1)
- 别名
- Presenilin-1 (PSEN1 产品)
- 别名
- pre1 Protein, psen Protein, zfPS1 Protein, zf-PS1 Protein, ad3 Protein, fad Protein, ps1 Protein, s182 Protein, X-PS-beta Protein, X-PS-alpha Protein, AD3 Protein, FAD Protein, PS-1 Protein, PS1 Protein, S182 Protein, Ad3h Protein, presenilin 1 Protein, presenilin 1 L homeolog Protein, psen1 Protein, PSEN1 Protein, Psen1 Protein, psen1.L Protein
- 背景
- Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.
- 分子量
- 52.5 kDa
- NCBI登录号
- NP_000012
- 途径
- Notch Signaling, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
-
