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PRKG1 Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)

PRKG1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
产品编号 ABIN2713946
发货至: 中国
  • 抗原 See all PRKG1 蛋白
    PRKG1 (Protein Kinase, CGMP-Dependent, Type I (PRKG1))
    蛋白类型
    Recombinant
    产品特性
    Transcript Variant 2
    宿主
    • 9
    • 3
    • 1
    资源
    • 3
    • 3
    • 2
    • 2
    • 1
    HEK-293 Cells
    标记
    This PRKG1 protein is labelled with Myc-DYKDDDDK Tag.
    应用范围
    Antibody Production (AbP), Standard (STD)
    产品特性
    • Recombinant human CGK1 (transcript variant 2) protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    纯度
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product PRKG1 蛋白
  • 应用备注
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    说明

    The tag is located at the C-terminal.

    限制
    仅限研究用
  • 浓度
    50 μg/mL
    缓冲液
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    储存条件
    -80 °C
    储存方法
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • 抗原
    PRKG1 (Protein Kinase, CGMP-Dependent, Type I (PRKG1))
    别名
    Cgk1 (PRKG1 产品)
    别名
    prkg1 Protein, zgc:63955 Protein, Pkgi Protein, cGk1 Protein, 1 Protein, PKG Protein, PRKG1B Protein, PRKGR1B Protein, cGK Protein, cGK 1 Protein, cGK1 Protein, cGKI Protein, cGKI-BETA Protein, cGKI-alpha Protein, CGKI Protein, cGKI-beta Protein, AW125416 Protein, Gm19690 Protein, Prkg1b Protein, Prkgr1b Protein, Prkg1beta Protein, protein kinase, cGMP-dependent, type Ia Protein, protein kinase, cGMP-dependent, type I Protein, protein kinase, cGMP-dependent, type 1 Protein, prkg1a Protein, PRKG1 Protein, prkg1 Protein, Prkg1 Protein
    背景
    Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity.
    分子量
    77.6 kDa
    NCBI登录号
    NP_006249
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