C9ORF72 Protein (His tag)
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- 抗原 See all C9ORF72 蛋白
- C9ORF72 (Chromosome 9 Open Reading Frame 72 (C9ORF72))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This C9ORF72 protein is labelled with His tag.
- 应用范围
- Antibody Production (AbP), Standard (STD)
- 产品特性
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- Recombinant human C9orf72 (full length, N-term HIS tag, transcript variant 1) protein expressed in E.coli.
- Produced with end-sequenced ORF clone
- 纯度
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product C9ORF72 蛋白
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Chromosome 9 Open Reading Frame 72 (C9ORF72) (AA 1-198) protein (His-IF2DI Tag)
C9ORF72 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % by SDS-PAGE gel analyses ELISA, WB
Chromosome 9 Open Reading Frame 72 (C9ORF72) (AA 1-481) protein (GST tag)C9ORF72 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Chromosome 9 Open Reading Frame 72 (C9ORF72) (AA 1-481) protein (Strep Tag)Crystallography grade C9ORF72 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
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- 应用备注
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - 说明
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The tag is located at the N-terminal.
- 限制
- 仅限研究用
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- 浓度
- 50 μg/mL
- 缓冲液
- 25 mM Tris, pH 8.0, 500 mM NaCl, 10 % glycerol.
- 储存条件
- -80 °C
- 储存方法
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- 抗原
- C9ORF72 (Chromosome 9 Open Reading Frame 72 (C9ORF72))
- 别名
- c9orf72 (C9ORF72 产品)
- 别名
- CZH9orf72 Protein, ALSFTD Protein, FTDALS Protein, AI840585 Protein, c9orf72 Protein, chromosome Z C9orf72 homolog Protein, chromosome 9 open reading frame 72 Protein, RIKEN cDNA 3110043O21 gene Protein, similar to RIKEN cDNA 3110043O21 Protein, chromosome 9 open reading frame 72 L homeolog Protein, CZH9orf72 Protein, C9orf72 Protein, 3110043O21Rik Protein, RGD1359108 Protein, c9orf72.L Protein
- 背景
- The protein encoded by this gene plays an important role in the regulation of endosomal trafficking, and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778, 21944779). Studies suggest that hexanucleotide expansions could result in the selective stabilization of repeat-containing pre-mRNA, and the accumulation of insoluble dipeptide repeat protein aggregates that could be pathogenic in FTD-ALS patients (PMID: 23393093). Alternative splicing results in multiple transcript variants encoding different isoforms.
- 分子量
- 24.6 kDa
- NCBI登录号
- NP_659442
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