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- 抗原 See all KDM4C 蛋白
- KDM4C (Lysine (K)-Specific Demethylase 4C (KDM4C))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- Baculovirus
- 标记
- This KDM4C protein is labelled with DYKDDDDK Tag.
- 应用范围
- Enzyme Activity Assay (EAA), Screening Assay (ScA)
- 产品特性
- Recombinant JMJD2C / KDM4C (accession number NP_055876.2) was expressed in Sf9 cells and contains an N-terminal FLAG tag with a calculated molecular weight of 124.1 kDa.
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- Discover our top product KDM4C 蛋白
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Lysine (K)-Specific Demethylase 4C (KDM4C) (AA 1-1056) protein (Strep Tag)
Crystallography grade KDM4C 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Lysine (K)-Specific Demethylase 4C (KDM4C) (AA 1-1054) protein (Strep Tag)Crystallography grade KDM4C 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Lysine (K)-Specific Demethylase 4C (KDM4C) protein (Myc-DYKDDDDK Tag)KDM4C 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 应用备注
- Recombinant JMJD2C / KDM4C is suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling. Specific Activity: H3K9me3 and H3K36me3 demethylase. Catalytic Activity: >100 turnovers/ enzyme molecule Histone Demethylase Assay Conditions: 50 mM HEPES pH 7.5, 0.02 % Triton X100, 100 μM 2OG, 100 μM Ascorbate, 50 μM (NH4)2Fe(SO4)2•6H2O, 1 mM TCEP, 60 nM Recombinant JMJD2C / KDM4C protein, and 3.3 μM H3K9me3 (aa 1-21) peptide at 2 hours at room temperature. MALDI-TOF was used for detection.
- 限制
- 仅限研究用
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- 注意事项
- Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
- 储存条件
- -80 °C
- 储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation.
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- 抗原
- KDM4C (Lysine (K)-Specific Demethylase 4C (KDM4C))
- 别名
- JMJD2C / KDM4C (KDM4C 产品)
- 别名
- JMJD2C Protein, GASC1 Protein, JHDM3C Protein, TDRD14C Protein, bA146B14.1 Protein, 2410141F18Rik Protein, AA517467 Protein, Gasc1 Protein, Jmjd2c Protein, lysine demethylase 4C Protein, jumonji domain containing 2c Protein, lysine (K)-specific demethylase 4C Protein, KDM4C Protein, Jmjd2c Protein, kdm4c Protein, Kdm4c Protein
- 背景
- KDM4C (lysine (K)-specific demethylase 4C), also known as JMJD2C (Jumonji Domain Containing 2C) is a nuclear protein that functions as a trimethylation-specific histone demethylase that preferentially demethylates trimethylated lysine 9 (K9me3) and lysine 36 (K36me3) residues of histone H3, converting these trimethylated histone residues to dimethylated form. KDM4C has no activity for mono- and dimethylated H3K9 and H3K36. Chromosomal aberrations and overexpression of KDM4C are associated with esophageal squamous cell carcinoma. KDM4C regulates colonosphere formation in colorectal cancers by mediating the crosstalk between Wnt and Notch signaling pathways.
- 分子量
- 124.1 kDa
- 途径
- Nuclear Hormone Receptor Binding, Warburg Effect
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